Literature DB >> 29222794

Active Induction of Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice.

Gabriella Contarini1, Pietro Giusti1, Stephen D Skaper2.   

Abstract

The protocol in this chapter presents a method to actively induce experimental autoimmune encephalomyelitis (EAE), one of the most widely used animal models to study efficacy of potential drugs for treatment of multiple sclerosis. Multiple sclerosis is an inflammatory, demyelinating disease of the central nervous system and the most common cause of chronic neurological impairment in young people. In this model EAE is induced in female C57BL/6 mice by immunization with an emulsion of myelin oligodendrocyte glycoprotein (fragment 35-55) in complete Freund's adjuvant, followed by administration of pertussis toxin in phosphate-buffered saline. EAE is evidenced by ascending flaccid paralysis with inflammation targeting the spinal cord.

Entities:  

Keywords:  Autoimmune; Demyelination; Experimental autoimmune encephalomyelitis; Inflammation; Multiple sclerosis; Oligodendrocyte

Mesh：

Substances：

Year:  2018        PMID： 29222794     DOI： 10.1007/978-1-4939-7571-6_26

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  6 in total

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Journal:  Physiol Res       Date:  2022-01-19       Impact factor: 1.881

2.  MS CD49d+CD154+ Lymphocytes Reprogram Oligodendrocytes into Immune Reactive Cells Affecting CNS Regeneration.

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3.  MW‑9, a chalcones derivative bearing heterocyclic moieties, attenuates experimental autoimmune encephalomyelitis via suppressing pathogenic TH17 cells.

Authors:  Bei Liu; Zewei Mao; Na Yin; Qianlan Gu; Qianlan Gu; Yan Qi; Xiaosi Li; Haihao Yang; Zhao Wu; Nanting Zou; Sai Ying; Chunping Wan
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4.  N-Acylethanolamine-Hydrolyzing Acid Amidase Inhibition, but Not Fatty Acid Amide Hydrolase Inhibition, Prevents the Development of Experimental Autoimmune Encephalomyelitis in Mice.

Authors:  Pauline Bottemanne; Owein Guillemot-Legris; Adrien Paquot; Julien Masquelier; Michael Malamas; Alexandros Makriyannis; Mireille Alhouayek; Giulio G Muccioli
Journal:  Neurotherapeutics       Date:  2021-07-07       Impact factor: 6.088

5.  Immune Thymic Profile of the MOG-Induced Experimental Autoimmune Encephalomyelitis Mouse Model.

Authors:  Sofia P das Neves; Cláudia Serre-Miranda; Claudia Nobrega; Susana Roque; João J Cerqueira; Margarida Correia-Neves; Fernanda Marques
Journal:  Front Immunol       Date:  2018-10-11       Impact factor: 7.561

6.  T Regulatory Cells From Non-obese Diabetic Mice Show Low Responsiveness to IL-2 Stimulation and Exhibit Differential Expression of Anergy-Related and Ubiquitination Factors.

Authors:  Gloria J Godoy; Carolina Olivera; Daniela A Paira; Florencia C Salazar; Yamile Ana; Cinthia C Stempin; Ruben D Motrich; Virginia E Rivero
Journal:  Front Immunol       Date:  2019-11-25       Impact factor: 7.561
  6 in total

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