Andrés L Echazarreta1, Sergio J Arias2, Ricardo Del Olmo3, Eduardo R Giugno4, Federico D Colodenco3, Santiago C Arce5, Juan C Bossio2, Gustavo Armando2, Joan B Soriano6. 1. Hospital Interzonal Especializado de Agudos y Crónicos San Juan de Dios, La Plata, Argentina. Electronic address: aechaza@gmail.com. 2. Instituto Nacional de Enfermedades Respiratorias Emilio Coni, Ministerio de Salud de la Nación, Santa Fe, Argentina. 3. Hospital María Ferrer , Ciudad Autónoma de Buenos Aires, Argentina. 4. Hospital Dr. Antonio A. Cetrángolo, Ciudad Autónoma de Buenos Aires, Argentina. 5. Instituto de Investigaciones Médicas A. Lanari, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina. 6. Instituto de Investigación Hospital Universitario de la Princesa (IISP), Universidad Autónoma de Madrid, Madrid, España.
Abstract
INTRODUCTION: The prevalence of chronic obstructive pulmonary disease (COPD) has not been studied in Argentina. OBJECTIVES: To determine the prevalence and relevant clinical characteristics of COPD in a representative sample. MATERIAL AND METHODS: We performed a cross-sectional study in a population of adults aged ≥ 40 years randomly selected by cluster sampling in 6 urban locations. Subjects answered a structured survey and performed pre- and post-bronchodilator spirometry (PBD). COPD was defined as FEV1/FVC ratio < 0.7 predicted value. The total prevalence was estimated for each cluster with its 95% confidence interval (CI). RESULTS: Of 4,599 surveys and 3,999 spirometries, 3,469 were considered of adequate quality (86.8%) for our study. The prevalence of COPD was 14.5% (CI: 13.4-15.7). The distribution of COPD cases according to FEV1 (GOLD 2017) was stage 1: 38% (CI: 34-43); stage 2: 52% (CI: 47-56); stage 3: 10% (CI: 7-13); and stage 4: 1% (CI: 0-2), and according to the refined ABCD (GOLD 2017) assessment: A: 52% (CI: 47-56); B: 43% (CI: 39-48); C: 1% (CI: 0-2); D: 4% (CI: 2-6). The rate of underdiagnosis was 77.4% (CI 73.7-81.1%) and diagnostic error 60.7% (CI 55.1-66.3%). A significant association was found between COPD and age (OR 3.77 in individuals 50-59 years of age and 19.23 in those > 80 years), male gender (OR 1.62; CI 1.31-2), smoking (OR 1.95; CI 1.49-2.54), low socioeconomic status (OR 1.33; CI 1.02-1.73), and previous tuberculosis (OR 3.3; CI 1.43-7.62). CONCLUSIONS: We estimate that more than 2.3 million Argentineans have COPD, with high rates of underdiagnosis and diagnostic error.
INTRODUCTION: The prevalence of chronic obstructive pulmonary disease (COPD) has not been studied in Argentina. OBJECTIVES: To determine the prevalence and relevant clinical characteristics of COPD in a representative sample. MATERIAL AND METHODS: We performed a cross-sectional study in a population of adults aged ≥ 40 years randomly selected by cluster sampling in 6 urban locations. Subjects answered a structured survey and performed pre- and post-bronchodilator spirometry (PBD). COPD was defined as FEV1/FVC ratio < 0.7 predicted value. The total prevalence was estimated for each cluster with its 95% confidence interval (CI). RESULTS: Of 4,599 surveys and 3,999 spirometries, 3,469 were considered of adequate quality (86.8%) for our study. The prevalence of COPD was 14.5% (CI: 13.4-15.7). The distribution of COPD cases according to FEV1 (GOLD 2017) was stage 1: 38% (CI: 34-43); stage 2: 52% (CI: 47-56); stage 3: 10% (CI: 7-13); and stage 4: 1% (CI: 0-2), and according to the refined ABCD (GOLD 2017) assessment: A: 52% (CI: 47-56); B: 43% (CI: 39-48); C: 1% (CI: 0-2); D: 4% (CI: 2-6). The rate of underdiagnosis was 77.4% (CI 73.7-81.1%) and diagnostic error 60.7% (CI 55.1-66.3%). A significant association was found between COPD and age (OR 3.77 in individuals 50-59 years of age and 19.23 in those > 80 years), male gender (OR 1.62; CI 1.31-2), smoking (OR 1.95; CI 1.49-2.54), low socioeconomic status (OR 1.33; CI 1.02-1.73), and previous tuberculosis (OR 3.3; CI 1.43-7.62). CONCLUSIONS: We estimate that more than 2.3 million Argentineans have COPD, with high rates of underdiagnosis and diagnostic error.
Authors: Juan J Olortegui-Rodriguez; David R Soriano-Moreno; Alejandro Benites-Bullón; Pilar P Pelayo-Luis; Jorge Huaringa-Marcelo Journal: BMC Pulm Med Date: 2022-07-16 Impact factor: 3.320
Authors: María Abad-Arranz; Ana Moran-Rodríguez; Enrique Mascarós Balaguer; Carmen Quintana Velasco; Laura Abad Polo; Sara Núñez Palomo; Jaime Gonzálvez Rey; Ana María Fernández Vargas; Antonio Hidalgo Requena; Jose Manuel Helguera Quevedo; Marina García Pardo; Jose Luis Lopez-Campos Journal: Int J Chron Obstruct Pulmon Dis Date: 2019-06-06
Authors: Laura Naranjo; Carlos A Torres-Duque; Daniel Colodenco; Gustavo Lopardo; Pablo Rodriguez; Aldo Agra de Albuquerque-Neto; Rafael J Hernandez-Zenteno; Luis Septien; Reynaldo Chandler; Eduardo Ortega-Barria; Patricia Juliao; Adriana Guzman-Holst Journal: Int J Chron Obstruct Pulmon Dis Date: 2020-08-06