| Literature DB >> 29221764 |
Seyed Fazel Nabavi1, Antoni Sureda2, Ahmad Reza Dehpour3, Samira Shirooie4, Ana Sanches Silva5, Kasi Pandima Devi6, Touqeer Ahmed7, Nafeesa Ishaq8, Rabia Hashim8, Eduardo Sobarzo-Sánchez9, Maria Daglia10, Nady Braidy11, Mariateresa Volpicella12, Rosa Anna Vacca13, Seyed Mohammad Nabavi14.
Abstract
In the present paper, we will discuss on the importance of autophagy in the central nervous system, and outline the relation between autophagic pathways and the pathogenesis of neurodegenerative disorders. The potential therapeutic benefits of naturally occurring phytochemicals as pharmacological modulators of autophagy will also be addressed. Our findings provide renewed insight on the molecular modes of protection by polyphenols, which is likely to be at least in part mediated not only by their potent antioxidant and anti-inflammatory effects, but also through modulation of autophagic processes to remove the aberrant protein aggregates.Entities:
Keywords: Alzheimer's disease; Autophagy; Neurodegeneration; Parkinson's disease; Polyphenols
Mesh：
Substances：
Year: 2017 PMID： 29221764 DOI： 10.1016/j.biotechadv.2017.12.001
Source DB: PubMed Journal: Biotechnol Adv ISSN： 0734-9750 Impact factor: 14.227