| Literature DB >> 29221704 |
Jian-Hai Ding1, Zheng-Hui Li2, Tao Feng3, Ji-Kai Liu4.
Abstract
Five new tremulane sesquiterpenes, named irlactins F-J (1-5), were isolated from cultures of the basidiomycete Irpex lacteus together with two known analogues (6 and 7). Structures and relative configurations of compounds 1-5 were elucidated by spectroscopic data analysis. Compund 4 exhibited moderate cytotoxicities on HL-60, SMMC-7721, A-549, MCF-7, and SW480 cells with IC50 values of 16.23, 20.40, 25.55, 19.05, and 18.58μM, respectively.Entities:
Keywords: Cytotoxicity; Irpex lacteus; Secondary metabolites; Tremulane sesquiterpenes
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Year: 2017 PMID： 29221704 DOI： 10.1016/j.fitote.2017.12.001
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882