Literature DB >> 2921865

In vitro toxicity of topical antimicrobial agents to human fibroblasts.

R L McCauley1, H A Linares, V Pelligrini, D N Herndon, M C Robson, J P Heggers.   

Abstract

Topical antimicrobial agents are essential to optimal burn care. However, exposure of WI-38 human diploid fibroblasts (ATCC CCL 75) and fresh donor human dermal fibroblasts to silver sulfadiazine and mafenide acetate results in a significant reduction in cell proliferation, as determined by hemocytometer cell counts and total matrix protein assays, within 48 hr of exposure. Changes in cellular morphology and progressive deterioration of cytoplasmic organelles and the nucleus are seen with phase-contrast microscopy and transmission electron microscopy. These findings may explain the clinical observation of delayed wound healing after the use of topical antimicrobial agents.

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Year:  1989        PMID： 2921865     DOI： 10.1016/0022-4804(89)90069-3

Source DB:  PubMed          Journal:  J Surg Res        ISSN： 0022-4804            Impact factor:   2.192


  21 in total

Review 1.  Wound cleansing, topical antiseptics and wound healing.

Authors:  Bishara S Atiyeh; Saad A Dibo; Shady N Hayek
Journal:  Int Wound J       Date:  2009-12       Impact factor: 3.315

Review 2.  A clinical review of infected wound treatment with Vacuum Assisted Closure (V.A.C.) therapy: experience and case series.

Authors:  Allen Gabriel; Jaimie Shores; Brent Bernstein; Jean de Leon; Ravi Kamepalli; Tom Wolvos; Mona M Baharestani; Subhas Gupta
Journal:  Int Wound J       Date:  2009-10       Impact factor: 3.315

3.  Antibiotic eluting clay mineral (Laponite®) for wound healing application: an in vitro study.

Authors:  M Ghadiri; W Chrzanowski; R Rohanizadeh
Journal:  J Mater Sci Mater Med       Date:  2014-07-16       Impact factor: 3.896

4.  Direct evidence for uptake of intact liposomes encapsulating silver sulfadiazine by cultured human keratinocytes based on combined transmission electron microscopy and X-ray microanalysis.

Authors:  M Schaller; R Wurm; H C Korting
Journal:  Antimicrob Agents Chemother       Date:  1997-03       Impact factor: 5.191

5.  Negative Pressure Wound Therapy With Instillation (NPWTi) Better Reduces Post-debridement Bioburden in Chronically Infected Lower Extremity Wounds Than NPWT Alone.

Authors:  S G Goss; J A Schwartz; F Facchin; E Avdagic; C Gendics; J C Lantis
Journal:  J Am Coll Clin Wound Spec       Date:  2014-02-20

Review 6.  Current treatment recommendations for topical burn therapy.

Authors:  W W Monafo; M A West
Journal:  Drugs       Date:  1990-09       Impact factor: 9.546

Review 7.  Skin substitutes from cultured cells and collagen-GAG polymers.

Authors:  S T Boyce
Journal:  Med Biol Eng Comput       Date:  1998-11       Impact factor: 2.602

8.  Effects of granulocyte-macrophage colony-stimulating factor on wound contraction.

Authors:  M Robson; A Kucukcelebi; S S Carp; P G Hayward; P S Hui; W T Cowan; F Ko; D M Cooper
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1994       Impact factor: 3.267

9.  Noncytotoxic combinations of topical antimicrobial agents for use with cultured skin substitutes.

Authors:  S T Boyce; G D Warden; I A Holder
Journal:  Antimicrob Agents Chemother       Date:  1995-06       Impact factor: 5.191

10.  Incidence of embolism and paravalvar leak after St Jude Silzone valve implantation: experience from the Cardiff Embolic Risk Factor Study.

Authors:  A Ionescu; N Payne; A G Fraser; J Giddings; G L Grunkemeier; E G Butchart
Journal:  Heart       Date:  2003-09       Impact factor: 5.994
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