Nili Raz1,2,3,4, Amir Shalev5,6, Eran Horowitz5,6, Ariel Weissman5,6, Yossi Mizrachi5,6, Hadass Ganer Herman5,6, Arieh Raziel5,6. 1. IVF Unit, Department of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, Israel. NiliRaz@gmail.com. 2. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. NiliRaz@gmail.com. 3. Department of Obstetrics and Gynecology, Hillel Yaffe Medical Center, Hadera, Israel. NiliRaz@gmail.com. 4. The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel. NiliRaz@gmail.com. 5. IVF Unit, Department of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, Israel. 6. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Abstract
PURPOSE: The purpose of the study is to calculate the cumulative pregnancy rate and cumulative live birth rate in women undergoing in vitro fertilization (IVF) at ages 44-45. METHODS: The study calculated cumulative live pregnancy rate and cumulative live birth rate of 124 women aged 44 to 45 years old who commenced IVF treatment. MAIN OUTCOME MEASURES: The main outcome measures are cumulative live pregnancy rate and cumulative live birth rate. RESULTS: Cumulative live pregnancy rates following 1, 2, 3, and 4 cycles were 5.6, 11, 17, and 20%, respectively, with no additional pregnancies in further cycles. Cumulative live birth rates following 1, 2, and 3 cycles were 1.6, 3, and 7%, respectively, with no additional live births in further cycles. CONCLUSIONS: The cumulative pregnancy rate rises during the first 4 cycles and cumulative live birth rate rises during the first 3 cycles, with no additional rise in pregnancies or deliveries thereafter, suggesting that it is futile to offer more than 3 cycles of treatment to 44-45-year-old women.
PURPOSE: The purpose of the study is to calculate the cumulative pregnancy rate and cumulative live birth rate in women undergoing in vitro fertilization (IVF) at ages 44-45. METHODS: The study calculated cumulative live pregnancy rate and cumulative live birth rate of 124 women aged 44 to 45 years old who commenced IVF treatment. MAIN OUTCOME MEASURES: The main outcome measures are cumulative live pregnancy rate and cumulative live birth rate. RESULTS: Cumulative live pregnancy rates following 1, 2, 3, and 4 cycles were 5.6, 11, 17, and 20%, respectively, with no additional pregnancies in further cycles. Cumulative live birth rates following 1, 2, and 3 cycles were 1.6, 3, and 7%, respectively, with no additional live births in further cycles. CONCLUSIONS: The cumulative pregnancy rate rises during the first 4 cycles and cumulative live birth rate rises during the first 3 cycles, with no additional rise in pregnancies or deliveries thereafter, suggesting that it is futile to offer more than 3 cycles of treatment to 44-45-year-old women.
Authors: Sigal Klipstein; Meredith Regan; David A Ryley; Marlene B Goldman; Michael M Alper; Richard H Reindollar Journal: Fertil Steril Date: 2005-08 Impact factor: 7.329
Authors: Judy E Stern; Morton B Brown; Barbara Luke; Ethan Wantman; Avi Lederman; Stacey A Missmer; Mark D Hornstein Journal: Fertil Steril Date: 2009-07-10 Impact factor: 7.329