Literature DB >> 29218101

Delta/notch-like epidermal growth factor-related receptor (DNER) orchestrates stemness and cancer progression in prostate cancer.

Lijun Wang1, Qi Wu1, Shan Zhu1, Zhiyu Li1, Jingping Yuan2, Dehua Yu2,3, Zhiliang Xu1, Juanjuan Li1, Shengrong Sun1, Changhua Wang3.   

Abstract

DNER, Delta/Notch-like epidermal growth factor (EGF)-related receptor, is a neuron-specific transmembrane protein carrying extracellular EGF-like repeats. The function of DNER in prostate cancer has not been evaluated. Here, we showed that the upregulation of DNER is observed in various cancers, including prostate cancer. Knockdown of DNER in PC-3 cells inhibited cell proliferation, migration and invasion as well as tumorigenesis in PC-3 xenografts. DNER knockdown specifically inhibited cell growth in spheroids. RT-PCR and western blot analysis were performed, and CD44, HES1 and GLI1 expression was significantly decreased in DNER knockdown cells. Thus, DNER promotes prostate cancer progression and the growth of PC-3 cells by modulating the primary genes of cancer stem cells.

Entities:  

Keywords:  DNER; metastasis; proliferation; prostate cancer; stemness

Year:  2017        PMID： 29218101      PMCID： PMC5714787     

Source DB:  PubMed          Journal:  Am J Transl Res        ISSN： 1943-8141            Impact factor:   4.060


  30 in total

1.  DNER acts as a neuron-specific Notch ligand during Bergmann glial development.

Authors:  Mototsugu Eiraku; Akira Tohgo; Katsuhiko Ono; Megumi Kaneko; Kazuto Fujishima; Tomoo Hirano; Mineko Kengaku
Journal:  Nat Neurosci       Date:  2005-07       Impact factor: 24.884

Review 2.  Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update.

Authors:  Naoko Takebe; Lucio Miele; Pamela Jo Harris; Woondong Jeong; Hideaki Bando; Michael Kahn; Sherry X Yang; S Percy Ivy
Journal:  Nat Rev Clin Oncol       Date:  2015-04-07       Impact factor: 66.675

3.  GLI1, a crucial mediator of sonic hedgehog signaling in prostate cancer, functions as a negative modulator for androgen receptor.

Authors:  Guangchun Chen; Yutaka Goto; Ryuichi Sakamoto; Kimitaka Tanaka; Eri Matsubara; Masafumi Nakamura; Hong Zheng; Jian Lu; Ryoichi Takayanagi; Masatoshi Nomura
Journal:  Biochem Biophys Res Commun       Date:  2010-12-21       Impact factor: 3.575

4.  High expression of delta-like ligand 4 predicts poor prognosis after curative resection for pancreatic cancer.

Authors:  Hai-Tao Chen; Quan-Cai Cai; Jian-Ming Zheng; Xiao-Hua Man; Hui Jiang; Bin Song; Gang Jin; Wei Zhu; Zhao-Shen Li
Journal:  Ann Surg Oncol       Date:  2011-08-06       Impact factor: 5.344

5.  The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance.

Authors:  Karisa C Schreck; Pete Taylor; Luigi Marchionni; Vidya Gopalakrishnan; Eli E Bar; Nicholas Gaiano; Charles G Eberhart
Journal:  Clin Cancer Res       Date:  2010-12-15       Impact factor: 12.531

6.  Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons.

Authors:  Mototsugu Eiraku; Yutaka Hirata; Hiroshi Takeshima; Tomoo Hirano; Mineko Kengaku
Journal:  J Biol Chem       Date:  2002-04-11       Impact factor: 5.157

7.  Notch3 is activated by chronic hypoxia and contributes to the progression of human prostate cancer.

Authors:  Giovanna Danza; Claudia Di Serio; Maria Raffaella Ambrosio; Niccolò Sturli; Giuseppe Lonetto; Fabiana Rosati; Bruno Jim Rocca; Giuseppina Ventimiglia; Maria Teresa del Vecchio; Igor Prudovsky; Niccolò Marchionni; Francesca Tarantini
Journal:  Int J Cancer       Date:  2013-06-26       Impact factor: 7.396

8.  DNER, an epigenetically modulated gene, regulates glioblastoma-derived neurosphere cell differentiation and tumor propagation.

Authors:  Peng Sun; Shuli Xia; Bachchu Lal; Charles G Eberhart; Alfredo Quinones-Hinojosa; Jarek Maciaczyk; William Matsui; Francesco Dimeco; Sara M Piccirillo; Angelo L Vescovi; John Laterra
Journal:  Stem Cells       Date:  2009-07       Impact factor: 6.277

9.  Combination of Cancer Stem Cell Markers CD44 and CD24 Is Superior to ALDH1 as a Prognostic Indicator in Breast Cancer Patients with Distant Metastases.

Authors:  Yoshiya Horimoto; Atsushi Arakawa; Noriko Sasahara; Masahiko Tanabe; Sei Sai; Takanori Himuro; Mitsue Saito
Journal:  PLoS One       Date:  2016-10-21       Impact factor: 3.240

10.  Hes1 is involved in the self-renewal and tumourigenicity of stem-like cancer cells in colon cancer.

Authors:  Fei Gao; YuQin Zhang; ShengChun Wang; YuanQiang Liu; Lin Zheng; JianQuan Yang; Wei Huang; YanFen Ye; WeiRen Luo; Dong Xiao
Journal:  Sci Rep       Date:  2014-02-04       Impact factor: 4.379
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  8 in total

1.  Oncogene Delta/Notch-Like EGF-Related Receptor Promotes Cell Proliferation, Invasion, and Migration in Hepatocellular Carcinoma and Predicts a Poor Prognosis.

Authors:  Yan Liang; Hesheng Luo; Haidong Zhang; Youhong Dong; Ying Bao
Journal:  Cancer Biother Radiopharm       Date:  2018-09-20       Impact factor: 3.099

2.  Role of Delta/Notch-like epidermal growth factor-related receptor in gastric cancer patients and cells and its clinical significance.

Authors:  Hanchuan Tao; Cheng Wang; Yifan Zhu; Chongmei Lu; Xiaojun Zhou
Journal:  Anticancer Drugs       Date:  2022-09-29       Impact factor: 2.389

3.  Growth factors involve in cellular proliferation, differentiation and migration during prostate cancer metastasis.

Authors:  Ilaha Isali; Mohammed Adel Ali Al-Sadawi; Arshna Qureshi; Ahmad O Khalifa; Mukesh K Agrawal; Sanjeev Shukla
Journal:  Int J Cell Biol Physiol       Date:  2019-10-07

4.  The Notch ligand DNER regulates macrophage IFNγ release in chronic obstructive pulmonary disease.

Authors:  Carolina Ballester-López; Thomas M Conlon; Zeynep Ertüz; Flavia R Greiffo; Martin Irmler; Stijn E Verleden; Johannes Beckers; Isis E Fernandez; Oliver Eickelberg; Ali Önder Yildirim
Journal:  EBioMedicine       Date:  2019-05-04       Impact factor: 8.143

5.  Transcriptional Profiling Reveals the Regulatory Role of DNER in Promoting Pancreatic Neuroendocrine Neoplasms.

Authors:  Rui He; Wunai Zhang; Shuo Chen; Yang Liu; Wenbin Yang; Junhui Li
Journal:  Front Genet       Date:  2020-11-27       Impact factor: 4.599

6.  Prognostic signature of lung adenocarcinoma based on stem cell-related genes.

Authors:  Zhanghao Huang; Muqi Shi; Hao Zhou; Jinjie Wang; Hai-Jian Zhang; Jia -Hai Shi
Journal:  Sci Rep       Date:  2021-01-18       Impact factor: 4.379

7.  Inflammatory profiles in Chilean Mapuche and non-Mapuche women with gallstones at risk of developing gallbladder cancer.

Authors:  Sarah S Jackson; Vanessa Van De Wyngard; Ruth M Pfeiffer; Paz Cook; Allan Hildesheim; Ligia A Pinto; Sharon H Jackson; Kelvin Choi; Ricardo A Verdugo; Mara Cuevas; Cristian Yáñez; Eduardo Tobar-Calfucoy; Rocío Retamales-Ortega; Juan Carlos Araya; Catterina Ferreccio; Jill Koshiol
Journal:  Sci Rep       Date:  2021-02-11       Impact factor: 4.996

8.  DNER promotes epithelial-mesenchymal transition and prevents chemosensitivity through the Wnt/β-catenin pathway in breast cancer.

Authors:  Zhong Wang; Zhiyu Li; Qi Wu; Chenyuan Li; Juanjuan Li; Yimin Zhang; Changhua Wang; Si Sun; Shengrong Sun
Journal:  Cell Death Dis       Date:  2020-08-18       Impact factor: 8.469
  8 in total

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