Jennifer A Campbell1, Gail C Farmer2, Selena Nguyen-Rodriguez2, Rebekah Walker3, Leonard Egede4. 1. Department of Health Science, California State University, Long Beach, Long Beach, CA, USA; Department of Medicine, Division of General Internal Medicine, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA; Center for Patient Care and Outcomes Research (PCOR), Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. 2. Department of Health Science, California State University, Long Beach, Long Beach, CA, USA. 3. Department of Medicine, Division of General Internal Medicine, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA; Center for Patient Care and Outcomes Research (PCOR), Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. 4. Department of Medicine, Division of General Internal Medicine, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA; Center for Patient Care and Outcomes Research (PCOR), Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. Electronic address: legede@mcw.edu.
Abstract
AIMS: ACEs are known to increase risk for diabetes in adulthood. However, little is known about the differential impact of individual ACE categories on diabetes risk, and whether this relationship is gender specific. METHODS: Data from the 2011 BRFSS was used in this study. Participants included 48,526 adults who completed the ACE module across 5 states. Using logistic regression, we examined the odds of diabetes in adulthood related to eight individual categories of ACEs: sexual abuse, physical abuse, verbal abuse, mental illness, substance abuse, incarceration, separation/divorce, and violence. A gender interaction term was included to test if this relationship varied between men and women. RESULTS: In adjusted analyses, sexual abuse (OR 1.57, CI 1.240; 1.995) had the strongest positive association followed by verbal (OR 1.29, CI 1.117; 1.484) and physical abuse (OR 1.26, CI 1.040; 1.516). Having a parent with mental illness was also significantly associated with increased odds of diabetes (OR 1.19, CI 0.996; 1.416). No interaction between ACEs and diabetes status by gender in any of the eight categories was found. CONCLUSIONS: Overall, this study found that four ACE categories were significantly associated with increased odds of diabetes in adulthood with sexual abuse being the strongest predictor.
AIMS: ACEs are known to increase risk for diabetes in adulthood. However, little is known about the differential impact of individual ACE categories on diabetes risk, and whether this relationship is gender specific. METHODS: Data from the 2011 BRFSS was used in this study. Participants included 48,526 adults who completed the ACE module across 5 states. Using logistic regression, we examined the odds of diabetes in adulthood related to eight individual categories of ACEs: sexual abuse, physical abuse, verbal abuse, mental illness, substance abuse, incarceration, separation/divorce, and violence. A gender interaction term was included to test if this relationship varied between men and women. RESULTS: In adjusted analyses, sexual abuse (OR 1.57, CI 1.240; 1.995) had the strongest positive association followed by verbal (OR 1.29, CI 1.117; 1.484) and physical abuse (OR 1.26, CI 1.040; 1.516). Having a parent with mental illness was also significantly associated with increased odds of diabetes (OR 1.19, CI 0.996; 1.416). No interaction between ACEs and diabetes status by gender in any of the eight categories was found. CONCLUSIONS: Overall, this study found that four ACE categories were significantly associated with increased odds of diabetes in adulthood with sexual abuse being the strongest predictor.
Authors: Linda L Carpenter; Cyrena E Gawuga; Audrey R Tyrka; Janet K Lee; George M Anderson; Lawrence H Price Journal: Neuropsychopharmacology Date: 2010-09-29 Impact factor: 7.853
Authors: Janet W Rich-Edwards; Donna Spiegelman; Eileen N Lividoti Hibert; Hee-Jin Jun; Tamarra James Todd; Ichiro Kawachi; Rosalind J Wright Journal: Am J Prev Med Date: 2010-12 Impact factor: 5.043
Authors: Bernet M Elzinga; Karin Roelofs; Marieke S Tollenaar; Patricia Bakvis; Johannes van Pelt; Philip Spinhoven Journal: Psychoneuroendocrinology Date: 2007-12-21 Impact factor: 4.905
Authors: Andrea Gonzalez; Michael H Boyle; Hwme Hwme Kyu; Katholiki Georgiades; Laura Duncan; Harriet L MacMillan Journal: J Psychiatr Res Date: 2012-09-06 Impact factor: 4.791
Authors: Mukoso N Ozieh; Emma Garacci; Jennifer A Campbell; Rebekah J Walker; Leonard E Egede Journal: Am J Prev Med Date: 2020-08 Impact factor: 5.043