Vincent J Palmieri 1 , Melissa H Henshaw 1 , Janet Carter 1 , Shahryar M Chowdhury 1 Show Affiliations »
Abstract
AIM: The objectives of this study were to 1) compare the accuracy of waist:hip ratio (WHR) and waist:height ratio (WHtR) by determining their association with reference-standard measures derived from dual-energy X-ray absorptiometry (DXA) and 2) assess the relationship of DXA, WHR and WHtR to measures of dyslipidemia, insulin resistance and inflammation in children. METHODS: Subjects aged four to 21 were prospectively recruited. Truncal obesity by DXA was defined as the trunk fat:height ratio and trunk fat:nontrunk fat ratio. Three hundred and eight subjects were studied, and 246 (80%) were obese. RESULTS: There was a strong correlation between WHtR and trunk fat:height (r = 0.84, p < 0.01). DXA measures of truncal obesity had stronger correlations with measures of cardiometabolic risk than WHR and WHtR. Upon multivariable regression, only WHtR had independent associations with cholesterol/HDL, HOMA-IR and high-sensitivity c-reactive protein. CONCLUSION: WHtR is an accurate measure of truncal obesity. WHtR showed stronger associations with measures of insulin resistance and truncal obesity than WHR. ©2017 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
AIM: The objectives of this study were to 1) compare the accuracy of waist:hip ratio (WHR) and waist:height ratio (WHtR) by determining their association with reference-standard measures derived from dual-energy X-ray absorptiometry (DXA) and 2) assess the relationship of DXA, WHR and WHtR to measures of dyslipidemia , insulin resistance and inflammation in children . METHODS: Subjects aged four to 21 were prospectively recruited. Truncal obesity by DXA was defined as the trunk fat :height ratio and trunk fat :nontrunk fat ratio. Three hundred and eight subjects were studied, and 246 (80%) were obese . RESULTS: There was a strong correlation between WHtR and trunk fat :height (r = 0.84, p < 0.01). DXA measures of truncal obesity had stronger correlations with measures of cardiometabolic risk than WHR and WHtR. Upon multivariable regression, only WHtR had independent associations with cholesterol /HDL, HOMA-IR and high-sensitivity c-reactive protein . CONCLUSION: WHtR is an accurate measure of truncal obesity . WHtR showed stronger associations with measures of insulin resistance and truncal obesity than WHR. ©2017 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd.
Entities: Chemical
Disease
Gene
Species
Keywords:
Dyslipidemia; Insulin resistance; Obesity; Truncal fat
Mesh： See more »
Year: 2017
PMID： 29214673 PMCID： PMC5945318 DOI： 10.1111/apa.14175
Source DB: PubMed Journal: Acta Paediatr ISSN： 0803-5253 Impact factor: 2.299