Multilayer Cucurbit[6]uril-Based Magnetic Nanoparticles Prepared by Host-Guest Interaction: Remarkable Adsorbent for Low Density Lipoprotein Removal from Plasma.

Efficient removal of low density lipoprotein (LDL) is a key challenge due to its high level in plasma as a primary risk factor in the pathogenesis of atherosclerotic cardiovascular disease. In this work, a facile synthesis strategy based on host-guest interactions was developed to prepare multilayer cucurbit[6]uril-based magnetic nanoparticles, MNPs-(HA-DAH5 /HA-CB[6]5 ). The compound was employed as a blood purification material for the removal of LDL from plasma because it had good blood compatibility and could be easily separated with an external magnet. The efficient removal of LDL was attributed to the electrostatic interactions between the positive charged apoB-100 domain of LDL and the negative charged adsorbent. Moreover, the prepared material exhibited high recyclability and could release LDL in physiological saline for recyclable use. MNPs-(HA-DAH5 /HA-CB[6]5 ) offered promising perspectives and broad applications in extracorporeal treatment for the removal of LDL.