Dong Seok Yi1, Maxime Bertoux2, Eneida Mioshi3, John R Hodges4, Michael Hornberger4. 1. Neuroscience Research Australia, Sydney, Australia. 2. University Pierre and Marie Curie - Paris VI, Sorbonne Universités, Paris, France. 3. Neuroscience Research Australia, Sydney, Australia. School of Medical Sciences, University of New South Wales, Sydney, Australia. 4. Neuroscience Research Australia, Sydney, Australia. ARC Centre of Excellence in Cognition and its Disorders, Sydney, Australia. School of Medical Sciences, University of New South Wales, Sydney, Australia.
Abstract
Behavioural disturbances in frontotemporal dementia (FTD) are thought to reflect mainly atrophy of cortical regions. Recent studies suggest that subcortical brain regions, in particular the striatum, are also significantly affected and this pathology might play a role in the generation of behavioural symptoms. OBJECTIVE: To investigate prefrontal cortical and striatal atrophy contributions to behavioural symptoms in FTD. METHODS: One hundred and eighty-two participants (87 FTD patients, 39 AD patients and 56 controls) were included. Behavioural profiles were established using the Cambridge Behavioural Inventory Revised (CBI-R) and Frontal System Behaviour Scale (FrSBe). Atrophy in prefrontal (VMPFC, DLPFC) and striatal (caudate, putamen) regions was established via a 5-point visual rating scale of the MRI scans. Behavioural scores were correlated with atrophy rating scores. RESULTS: Behavioural and atrophy ratings demonstrated that patients were significantly impaired compared to controls, with bvFTD being most severely affected. Behavioural-anatomical correlations revealed that VMPFC atrophy was closely related to abnormal behaviour and motivation disturbances. Stereotypical behaviours were associated with both VMPFC and striatal atrophy. By contrast, disturbance of eating was found to be related to striatal atrophy only. CONCLUSION: Frontal and striatal atrophy contributed to the behavioural disturbances seen in FTD, with some behaviours related to frontal, striatal or combined fronto-striatal pathology. Consideration of striatal contributions to the generation of behavioural disturbances should be taken into account when assessing patients with potential FTD.
Behavioural disturbances in frontotemporal dementia (FTD) are thought to reflect mainly atrophy of cortical regions. Recent studies suggest that subcortical brain regions, in particular the striatum, are also significantly affected and this pathology might play a role in the generation of behavioural symptoms. OBJECTIVE: To investigate prefrontal cortical and striatal atrophy contributions to behavioural symptoms in FTD. METHODS: One hundred and eighty-two participants (87 FTD patients, 39 AD patients and 56 controls) were included. Behavioural profiles were established using the Cambridge Behavioural Inventory Revised (CBI-R) and Frontal System Behaviour Scale (FrSBe). Atrophy in prefrontal (VMPFC, DLPFC) and striatal (caudate, putamen) regions was established via a 5-point visual rating scale of the MRI scans. Behavioural scores were correlated with atrophy rating scores. RESULTS: Behavioural and atrophy ratings demonstrated that patients were significantly impaired compared to controls, with bvFTD being most severely affected. Behavioural-anatomical correlations revealed that VMPFC atrophy was closely related to abnormal behaviour and motivation disturbances. Stereotypical behaviours were associated with both VMPFC and striatal atrophy. By contrast, disturbance of eating was found to be related to striatal atrophy only. CONCLUSION: Frontal and striatal atrophy contributed to the behavioural disturbances seen in FTD, with some behaviours related to frontal, striatal or combined fronto-striatal pathology. Consideration of striatal contributions to the generation of behavioural disturbances should be taken into account when assessing patients with potential FTD.
Authors: H J Rosen; M L Gorno-Tempini; W P Goldman; R J Perry; N Schuff; M Weiner; R Feiwell; J H Kramer; B L Miller Journal: Neurology Date: 2002-01-22 Impact factor: 9.910
Authors: Howard J Rosen; Stephen C Allison; Guido F Schauer; Maria Luisa Gorno-Tempini; Michael W Weiner; Bruce L Miller Journal: Brain Date: 2005-09-29 Impact factor: 13.501
Authors: Katherine P Rankin; Maria Luisa Gorno-Tempini; Stephen C Allison; Christine M Stanley; Shenly Glenn; Michael W Weiner; Bruce L Miller Journal: Brain Date: 2006-09-28 Impact factor: 13.501
Authors: Bruno Dubois; Howard H Feldman; Claudia Jacova; Steven T Dekosky; Pascale Barberger-Gateau; Jeffrey Cummings; André Delacourte; Douglas Galasko; Serge Gauthier; Gregory Jicha; Kenichi Meguro; John O'brien; Florence Pasquier; Philippe Robert; Martin Rossor; Steven Salloway; Yaakov Stern; Pieter J Visser; Philip Scheltens Journal: Lancet Neurol Date: 2007-08 Impact factor: 44.182
Authors: Eneida Mioshi; Kate Dawson; Joanna Mitchell; Robert Arnold; John R Hodges Journal: Int J Geriatr Psychiatry Date: 2006-11 Impact factor: 3.485
Authors: Christopher M Kipps; R Rhys Davies; Joanna Mitchell; Jillian J Kril; Glenda M Halliday; John R Hodges Journal: Dement Geriatr Cogn Disord Date: 2007-03-19 Impact factor: 2.959
Authors: Annabel Nelson; Lucy L Russell; Georgia Peakman; Rhian S Convery; Arabella Bouzigues; Caroline V Greaves; Martina Bocchetta; David M Cash; John C van Swieten; Lize Jiskoot; Fermin Moreno; Raquel Sanchez-Valle; Robert Laforce; Caroline Graff; Mario Masellis; Maria Carmela Tartaglia; James B Rowe; Barbara Borroni; Elizabeth Finger; Matthis Synofzik; Daniela Galimberti; Rik Vandenberghe; Alexandre de Mendonça; Chris R Butler; Alexander Gerhard; Simon Ducharme; Isabelle Le Ber; Isabel Santana; Florence Pasquier; Johannes Levin; Markus Otto; Sandro Sorbi; Jonathan D Rohrer Journal: Ann Clin Transl Neurol Date: 2022-03-26 Impact factor: 5.430
Authors: Rachel H Tan; Emma Devenney; Matthew C Kiernan; Glenda M Halliday; John R Hodges; Michael Hornberger Journal: Front Aging Neurosci Date: 2015-07-02 Impact factor: 5.750
Authors: Maxime Bertoux; Claire O'Callaghan; Emma Flanagan; John R Hodges; Michael Hornberger Journal: Front Neurol Date: 2015-07-01 Impact factor: 4.003
Authors: Rachel H Tan; Emma Devenney; Carol Dobson-Stone; John B Kwok; John R Hodges; Matthew C Kiernan; Glenda M Halliday; Michael Hornberger Journal: PLoS One Date: 2014-08-21 Impact factor: 3.240
Authors: Ratko Radakovic; Vaisakh Puthusseryppady; Emma Flanagan; Matthew C Kiernan; Eneida Mioshi; Michael Hornberger Journal: Dement Neuropsychol Date: 2018 Oct-Dec
Authors: Lars Frings; Belinda Yew; Emma Flanagan; Bonnie Y K Lam; Michael Hüll; Hans-Jürgen Huppertz; John R Hodges; Michael Hornberger Journal: PLoS One Date: 2014-03-03 Impact factor: 3.240
Authors: Lucy L Russell; Caroline V Greaves; Martina Bocchetta; Jennifer Nicholas; Rhian S Convery; Katrina Moore; David M Cash; John van Swieten; Lize Jiskoot; Fermin Moreno; Raquel Sanchez-Valle; Barbara Borroni; Robert Laforce; Mario Masellis; Maria Carmela Tartaglia; Caroline Graff; Emanuela Rotondo; Daniela Galimberti; James B Rowe; Elizabeth Finger; Matthis Synofzik; Rik Vandenberghe; Alexandre de Mendonça; Fabrizio Tagliavini; Isabel Santana; Simon Ducharme; Chris Butler; Alex Gerhard; Johannes Levin; Adrian Danek; Markus Otto; Jason D Warren; Jonathan D Rohrer Journal: Cortex Date: 2020-09-26 Impact factor: 4.027