Barış Büke1, Emre Destegül2, Hatice Akkaya1, Deniz Şimşek3, Mert Kazandi3. 1. a Kayseri Training and Research Hospital, Department of Obstetrics and Gynecology , Kayseri , Turkey. 2. b Nigde Omer Halisdemir University Medical Faculty, Training and Research Hospital, Department of Obstetrics and Gynecology , Nigde/Turkey. 3. c Ege University Medical Faculty Hospital, Department of Obstetrics and Gynecology , İzmir , Turkey.
Abstract
OBJECTIVE: We aimed with this study to evaluate the role of pulmonary artery acceleration time to ejection time ratio (PATET) in the prediction of respiratory distress syndrome (RDS) in preterm neonates. MATERIALS AND METHODS: In this prospective cohort study, 105 singleton pregnant women with no congenital abnormalities and pregnancy complications who delivered before 37 weeks of gestational age were included. All the patients underwent ultrasound examination to obtain fetal pulmonary artery Doppler. 15 patients were excluded from the study as they did not give birth within 3 days subsequent to ultrasound examination, or inadequate Doppler measurements. After delivery the neonates were grouped according to diagnosis of RDS as RDS + and RDS-. RESULTS: One hundred five women met the inclusion criteria. Regarding the Doppler findings; only the PATET ratio was significantly different between the groups (0.2965 ± 0.042 versus 0.386 ± 0.068 p < .001, Z = -5.206). There was an inverse correlation between the diagnosis of RDS in the neonates and the PATET values, even after adjusted for gestational age estimated fetal weight and fetal gender (r = -0.52 and p = .0017). A cut-off value of 0.327 provided optimal specificity of 77.1%, a sensitivity of 90.9%, a negative predictive value of 95.4%, and a positive predictive value 52.7%. CONCLUSIONS: In consideration of these results fetal PATET ratio is a promising noninvasive tool to predict RDS in cases of preterm deliveries.
OBJECTIVE: We aimed with this study to evaluate the role of pulmonary artery acceleration time to ejection time ratio (PATET) in the prediction of respiratory distress syndrome (RDS) in preterm neonates. MATERIALS AND METHODS: In this prospective cohort study, 105 singleton pregnant women with no congenital abnormalities and pregnancy complications who delivered before 37 weeks of gestational age were included. All the patients underwent ultrasound examination to obtain fetal pulmonary artery Doppler. 15 patients were excluded from the study as they did not give birth within 3 days subsequent to ultrasound examination, or inadequate Doppler measurements. After delivery the neonates were grouped according to diagnosis of RDS as RDS + and RDS-. RESULTS: One hundred five women met the inclusion criteria. Regarding the Doppler findings; only the PATET ratio was significantly different between the groups (0.2965 ± 0.042 versus 0.386 ± 0.068 p < .001, Z = -5.206). There was an inverse correlation between the diagnosis of RDS in the neonates and the PATET values, even after adjusted for gestational age estimated fetal weight and fetal gender (r = -0.52 and p = .0017). A cut-off value of 0.327 provided optimal specificity of 77.1%, a sensitivity of 90.9%, a negative predictive value of 95.4%, and a positive predictive value 52.7%. CONCLUSIONS: In consideration of these results fetal PATET ratio is a promising noninvasive tool to predict RDS in cases of preterm deliveries.
Entities:
Keywords:
Doppler ultrasound; PATET; prenatal diagnosis; pulmonary artery acceleration to ejection time ratio; respiratory distress syndrome
Authors: Anna Niesłuchowska-Hoxha; Wojciech Cnota; Bartosz Czuba; Aleksandra Ruci; Magdalena Ciaciura-Jarno; Agnieszka Jagielska; Dominik Wójtowicz; Rafał Kierach; Krzysztof Dąbrowski; Marcin Sidorowicz; Wioletta Skrzypulec-Plinta; Agata Wloch; Dariusz Borowski; Piotr Węgrzyn Journal: Biomed Res Int Date: 2018-10-04 Impact factor: 3.411