Literature DB >> 2921214

Isolation and characterization of new antibiotics resorcinomycins A and B.

E Kondo1, T Katayama, Y Kawamura, Y Yasuda, K Matsumoto, K Ishii, T Tanimoto, H Hinoo, T Kato, H Kyotani.   

Abstract

New antibiotics, resorcinomycins A and B, were isolated from the culture broth of a streptomycete strain identified as Streptoverticillium roseoverticillatum. The antibiotics are water-soluble amphoteric substances, positive to SAKAGUCHI'S reagent. The molecular formulas C14H20N4O5 and C13H18N4O5 for A and B were indicated by elemental analysis and secondary ion MS. The structures of these antibiotics were determined by 1H and 13C NMR spectrometry and some chemical evidences to be N-[(S)-alpha-guanidino-3,5-dihydroxy-4-isopropylphenylacetyl]glyci ne and N-[(S)-alpha-guanidino-3,5-dihydroxy-4-ethylphenylacetyl]-glycine, respectively.

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Year:  1989        PMID: 2921214     DOI: 10.7164/antibiotics.42.1

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN: 0021-8820            Impact factor:   2.649


  4 in total

1.  Structure and activity relationships of the anti-Mycobacterium antibiotics resorcinomycin and pheganomycin.

Authors:  Yasushi Ogasawara; Koichi Ooya; Michiko Fujimori; Motoyoshi Noike; Tohru Dairi
Journal:  J Antibiot (Tokyo)       Date:  2015-08-26       Impact factor: 2.649

2.  Enhanced intramacrophage activity of resorcinomycin A against Mycobacterium avium-Mycobacterium intracellulare complex after liposome encapsulation.

Authors:  R Gomez-Flores; R Hsia; R Tamez-Guerra; R T Mehta
Journal:  Antimicrob Agents Chemother       Date:  1996-11       Impact factor: 5.191

3.  In vitro activities of free and liposomal drugs against Mycobacterium avium-M. intracellulare complex and M. tuberculosis.

Authors:  R T Mehta; A Keyhani; T J McQueen; B Rosenbaum; K V Rolston; J J Tarrand
Journal:  Antimicrob Agents Chemother       Date:  1993-12       Impact factor: 5.191

4.  Determination of MICs for Mycobacterium avium-M. intracellulare complex in liquid medium by a colorimetric method.

Authors:  R Gomez-Flores; S Gupta; R Tamez-Guerra; R T Mehta
Journal:  J Clin Microbiol       Date:  1995-07       Impact factor: 5.948

  4 in total

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