Literature DB >> 29211737

Correction: CD8+ T cells provide immune protection against murine disseminated endotheliotropic Orientia tsutsugamushi infection.

Guang Xu, Nicole L Mendell, Yuejin Liang, Thomas R Shelite, Yenny Goez-Rivillas, Lynn Soong, Donald H Bouyer, David H Walker.   

Abstract

[This corrects the article DOI: 10.1371/journal.pntd.0005763.].

Entities:  

Year:  2017        PMID: 29211737      PMCID: PMC5718426          DOI: 10.1371/journal.pntd.0006127

Source DB:  PubMed          Journal:  PLoS Negl Trop Dis        ISSN: 1935-2727


Fig 7A is incorrect. The label “CD8-/- Infected” should read “MHC I-/- Infected”. The authors have provided a corrected version here.
Fig 7

Histopathological comparison of MHC I-/- mice and WT mice infected with O. tsutsugamushi.

Foci of inflammation (arrows), including infiltration of macrophages and lymphocytes, were observed in infected mice (A, mag: 100x, 400x inset). Many apoptotic cells, possibly neutrophils, were observed in the liver of MHC I-/- mice. Increased necrosis and steatosis (arrows with circle end) were observed in the livers of MHC I-/- mice. Higher pathology scores indicating greater injury were observed in the livers of infected mice (B). There were significantly more apoptotic cells in the liver (C) and kidney (D) of MHC I-/- mice than their WT counterparts. All infected mice had increased apoptosis compared to uninfected mice. *, p<0.05; ***, p<0.001, n = 8; each tissue sample was blindly scored by four experienced investigators.

Histopathological comparison of MHC I-/- mice and WT mice infected with O. tsutsugamushi.

Foci of inflammation (arrows), including infiltration of macrophages and lymphocytes, were observed in infected mice (A, mag: 100x, 400x inset). Many apoptotic cells, possibly neutrophils, were observed in the liver of MHC I-/- mice. Increased necrosis and steatosis (arrows with circle end) were observed in the livers of MHC I-/- mice. Higher pathology scores indicating greater injury were observed in the livers of infected mice (B). There were significantly more apoptotic cells in the liver (C) and kidney (D) of MHC I-/- mice than their WT counterparts. All infected mice had increased apoptosis compared to uninfected mice. *, p<0.05; ***, p<0.001, n = 8; each tissue sample was blindly scored by four experienced investigators.
  1 in total

1.  CD8+ T cells provide immune protection against murine disseminated endotheliotropic Orientia tsutsugamushi infection.

Authors:  Guang Xu; Nicole L Mendell; Yuejin Liang; Thomas R Shelite; Yenny Goez-Rivillas; Lynn Soong; Donald H Bouyer; David H Walker
Journal:  PLoS Negl Trop Dis       Date:  2017-07-19
  1 in total
  2 in total

Review 1.  Scrub Typhus Pathogenesis: Innate Immune Response and Lung Injury During Orientia tsutsugamushi Infection.

Authors:  Brandon Trent; James Fisher; Lynn Soong
Journal:  Front Microbiol       Date:  2019-09-06       Impact factor: 5.640

2.  Polarized lung inflammation and Tie2/angiopoietin-mediated endothelial dysfunction during severe Orientia tsutsugamushi infection.

Authors:  Brandon Trent; Yuejin Liang; Yan Xing; Marisol Esqueda; Yang Wei; Nam-Hyuk Cho; Hong-Il Kim; Yeon-Sook Kim; Thomas R Shelite; Jiyang Cai; Jiaren Sun; Donald H Bouyer; Jinjun Liu; Lynn Soong
Journal:  PLoS Negl Trop Dis       Date:  2020-03-02
  2 in total

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