Results of postoperative irradiation of medulloblastoma in adults.

This study analyzes the results of combined surgery and radiation therapy in 13 cases of medulloblastoma in adults treated at the Institute of Oncology in Cracow between 1974-1980. There were 5 women and 8 men. The mean age of the patients was 22.4 years. The overall crude 5-year survival was 62%. Four patients developed recurrence at the primary site (in one case local recurrence was concurrent with pulmonary metastases). The posterior fossa dose in these patients was 2625, 3000, 4800, and 5000 cGy. All 5-year survivors received the posterior fossa dose ranging from 5000 to 5400 cGy. For optimal local control the posterior fossa dose of at least 5400 cGy is recommended, with prior irradiation of the whole cranio-spinal axis.