A D Farmer1,2,3, A-M L Wegeberg1,4, B Brock5, A R Hobson6, S D Mohammed2, S M Scott2, C E Bruckner-Holt3, J R Semler7, W L Hasler8, P M Hellström9, A M Drewes1, C Brock1,10. 1. Mech-Sense, Department of Gastroenterology & Hepatology, Aalborg and Clinical Institute, Aalborg University Hospital, Aalborg University, Denmark. 2. Neurogastroenterology Group, Centre for Neuroscience and Trauma, Blizard Institute, Wingate Institute of Neurogastroenterology, Barts and the London School of Medicine & Dentistry, Queen Mary University of London, London, UK. 3. Department of Gastroenterology, University Hospitals of North Midlands, Stoke-on-Trent, UK. 4. School of Medicine and Health, Aalborg University, Aalborg, Denmark. 5. Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark. 6. The Functional Gut Clinic, London, UK. 7. Medtronic, Sunnyvale, CA, USA. 8. Division of Gastroenterology, University of Michigan Health System, Ann Arbor, MI, USA. 9. Department of Medical Sciences, Uppsala University, Uppsala, Sweden. 10. Department of Pharmacotherapy and Development, University of Copenhagen, Copenhagen, Denmark.
Abstract
BACKGROUND: The wireless motility capsule concurrently measures temperature, pH and pressure as it traverses the gastrointestinal tract. AIMS: To describe normative values for motility/contractility parameters across age, gender and testing centres. METHODS: Healthy participants underwent a standardised wireless motility capsule assessment following an overnight fast and consumption of a meal of known nutritional content. Traces were divided into regions of interest and analysed using 2 software packages (MotiliGI and GIMS Data Viewer). Inter-observer agreement was independently assessed by 2 investigators. RESULTS: Normative data for motility/contractility parameters (maximum amplitude, mean peak amplitude, contraction frequency and motility index) are presented for 107 individuals (62 male, median age 40 years, range 18-78). MotiliGI-Gastric, small bowel and colonic maximal contraction amplitude correlated with age (r = .24, P = .01; r = .22, P = .02; and r = .2, P = .04 respectively). Small bowel motility index was higher in females than males (150.4 ± 12 vs 122 ± 7.6, P = .04). Inter-observer agreement was excellent for transit times, pH and contractility/motility parameters. GIMS Data viewer-Gastric, small bowel and colonic loge motility index correlated with the respective area under the contraction curve, total contractions, sum of amplitudes and contraction frequency (all r>.35, P < .0003) but not with transit times. CONCLUSIONS: Our analysis provides normative data for motility/contractility parameters. Log motility index summarises a number of measures. In future, the measurement of contractile activity with the wireless motility capsule may potentially aid in the diagnosis of disease states such as visceral myopathic disorders.
BACKGROUND: The wireless motility capsule concurrently measures temperature, pH and pressure as it traverses the gastrointestinal tract. AIMS: To describe normative values for motility/contractility parameters across age, gender and testing centres. METHODS: Healthy participants underwent a standardised wireless motility capsule assessment following an overnight fast and consumption of a meal of known nutritional content. Traces were divided into regions of interest and analysed using 2 software packages (MotiliGI and GIMS Data Viewer). Inter-observer agreement was independently assessed by 2 investigators. RESULTS: Normative data for motility/contractility parameters (maximum amplitude, mean peak amplitude, contraction frequency and motility index) are presented for 107 individuals (62 male, median age 40 years, range 18-78). MotiliGI-Gastric, small bowel and colonic maximal contraction amplitude correlated with age (r = .24, P = .01; r = .22, P = .02; and r = .2, P = .04 respectively). Small bowel motility index was higher in females than males (150.4 ± 12 vs 122 ± 7.6, P = .04). Inter-observer agreement was excellent for transit times, pH and contractility/motility parameters. GIMS Data viewer-Gastric, small bowel and colonic loge motility index correlated with the respective area under the contraction curve, total contractions, sum of amplitudes and contraction frequency (all r>.35, P < .0003) but not with transit times. CONCLUSIONS: Our analysis provides normative data for motility/contractility parameters. Log motility index summarises a number of measures. In future, the measurement of contractile activity with the wireless motility capsule may potentially aid in the diagnosis of disease states such as visceral myopathic disorders.
Authors: Louise Ladebo; Pernille V Pedersen; Grzegorz J Pacyk; Jens Peter Kroustrup; Asbjørn M Drewes; Christina Brock; Anne E Olesen Journal: Obes Surg Date: 2021-03-12 Impact factor: 4.129
Authors: Anne-Marie Langmach Wegeberg; Christian Stevns Hansen; Adam D Farmer; Jesper Scott Karmisholt; Asbjorn M Drewes; Poul Erik Jakobsen; Birgitte Brock; Christina Brock Journal: United European Gastroenterol J Date: 2020-05-09 Impact factor: 4.623
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Authors: Mattis Bekkelund; Dag A Sangnes; Eirik Søfteland; Lars Aabakken; Martin Biermann; Elisabeth K Steinsvik; Trygve Hausken; Georg Dimcevski; Jan Gunnar Hatlebakk Journal: Clin Exp Gastroenterol Date: 2021-04-28
Authors: Dag A Sangnes; Katarina Lundervold; Mattis Bekkelund; Hilde L von Volkmann; Birgitte Berentsen; Odd Helge Gilja; Georg Dimcevski; Eirik Søfteland Journal: United European Gastroenterol J Date: 2021-10-23 Impact factor: 4.623
Authors: Jonas S Quist; Marie M Jensen; Kim K B Clemmensen; Hanne Pedersen; Natasja Bjerre; Joachim Størling; Martin B Blond; Nicolai J Wewer Albrechtsen; Jens J Holst; Signe S Torekov; Dorte Vistisen; Marit E Jørgensen; Satchidananda Panda; Christina Brock; Graham Finlayson; Kristine Færch Journal: BMJ Open Date: 2020-08-26 Impact factor: 2.692
Authors: Ditte S Kornum; Astrid J Terkelsen; Davide Bertoli; Mette W Klinge; Katrine L Høyer; Huda H A Kufaishi; Per Borghammer; Asbjørn M Drewes; Christina Brock; Klaus Krogh Journal: J Clin Med Date: 2021-03-31 Impact factor: 4.241