Pedro Pires1, Patricia Jungmann2, Jully Moura Galvão1, Adriano Hazin3, Luiza Menezes1, Ricardo Ximenes4, Gabriele Tonni5, Edward Araujo Júnior6. 1. Department of Maternal and Child, Pernambuco University (UPE), Recife, PE, Brazil. 2. Department of Pathology, Pernambuco University (UPE), Recife, PE, Brazil. 3. Department of Radiology, Instituto de Medicina Integral Professor Fernandes Figueira (IMIP), Recife, PE, Brazil. 4. Department of Tropical Medicine, Federal University of Pernambuco (UFPE), Recife, PE, Brazil. 5. Department of Obstetrics and Gynecology, AUSL Reggio Emilia, Guastalla Civil Hospital, Reggio Emilia, Italy. 6. Department of Obstetrics, Paulista School of Medicine, Federal University of São Paulo (EPM-UNIFESP), Rua Belchior de Azevedo, 156 apto. 111 Torre Vitoria, São Paulo, SP, CEP 05089-030, Brazil. araujojred@terra.com.br.
Abstract
PURPOSE: This study aimed to describe the prenatal and postnatal neuroimaging and clinical findings in a clinical series following congenital Zika virus syndrome during the first epidemic Zika virus (ZIKV) outbreak in the State of Pernambuco, Brazil. METHODS: We (the authors) conducted a retrospective study of a prospectively collected case series of fetuses and neonates with microcephaly born to mothers with presumed/confirmed congenital ZIKV syndrome. Prenatal ultrasound findings were reviewed to identify potential central nervous system (CNS) abnormalities. Neonates underwent postnatal neuroimaging follow up by computed tomography (CT)-scan or magnetic resonance (MR) imaging. RESULTS: The prenatal and postnatal outcomes of eight fetuses/neonates born to mothers with presumed/confirmed congenital ZIKV syndrome were examined. The mean gestational age at ultrasound was 31.3 weeks. Severe microcephaly was identified in seven fetuses (87.5%), while ventriculomegaly and brain calcifications were detected in all fetuses. The mean gestational age at delivery and head circumference were 38 weeks and 30.2 cm, respectively. All cases of microcephaly but one was confirmed postnatally. Brain CT scans or MRIs were performed in seven newborns, and all had periventricular and/or parenchymal calcifications, symmetrical or asymmetrical ventriculomegaly, pachygyria, and reduced sulcation and gyration. MR imaging aided the detection of one undetected case of corpus callosum dysgenesis and was essential in documenting reduced mantel of the cerebral cortex and reduced gyration and sulcation, especially involving the parietal lobe. In addition, MR imaging was also able to display irregular interfaces with the subcortical white matter, a finding consistent with polymicrogyria, more frequently seen at the level of the frontal lobe and atrophic and thinned pons. CONCLUSION: Severe microcephaly and CNS abnormalities may be associated with congenital ZIKV syndrome.
PURPOSE: This study aimed to describe the prenatal and postnatal neuroimaging and clinical findings in a clinical series following congenital Zika virus syndrome during the first epidemic Zika virus (ZIKV) outbreak in the State of Pernambuco, Brazil. METHODS: We (the authors) conducted a retrospective study of a prospectively collected case series of fetuses and neonates with microcephaly born to mothers with presumed/confirmed congenital ZIKV syndrome. Prenatal ultrasound findings were reviewed to identify potential central nervous system (CNS) abnormalities. Neonates underwent postnatal neuroimaging follow up by computed tomography (CT)-scan or magnetic resonance (MR) imaging. RESULTS: The prenatal and postnatal outcomes of eight fetuses/neonates born to mothers with presumed/confirmed congenital ZIKV syndrome were examined. The mean gestational age at ultrasound was 31.3 weeks. Severe microcephaly was identified in seven fetuses (87.5%), while ventriculomegaly and brain calcifications were detected in all fetuses. The mean gestational age at delivery and head circumference were 38 weeks and 30.2 cm, respectively. All cases of microcephaly but one was confirmed postnatally. Brain CT scans or MRIs were performed in seven newborns, and all had periventricular and/or parenchymal calcifications, symmetrical or asymmetrical ventriculomegaly, pachygyria, and reduced sulcation and gyration. MR imaging aided the detection of one undetected case of corpus callosum dysgenesis and was essential in documenting reduced mantel of the cerebral cortex and reduced gyration and sulcation, especially involving the parietal lobe. In addition, MR imaging was also able to display irregular interfaces with the subcortical white matter, a finding consistent with polymicrogyria, more frequently seen at the level of the frontal lobe and atrophic and thinned pons. CONCLUSION: Severe microcephaly and CNS abnormalities may be associated with congenital ZIKV syndrome.
Authors: Francisco Herlânio Costa Carvalho; Kárita Melo Cordeiro; Alberto Borges Peixoto; Gabriele Tonni; Antonio Fernandes Moron; Francisco Edson Lucena Feitosa; Helvécio Neves Feitosa; Edward Araujo Júnior Journal: Prenat Diagn Date: 2016-08-23 Impact factor: 3.050
Authors: J Erin Staples; Eric J Dziuban; Marc Fischer; Janet D Cragan; Sonja A Rasmussen; Michael J Cannon; Meghan T Frey; Christina M Renquist; Robert S Lanciotti; Jorge L Muñoz; Ann M Powers; Margaret A Honein; Cynthia A Moore Journal: MMWR Morb Mortal Wkly Rep Date: 2016-01-29 Impact factor: 17.586
Authors: Zachary A Klase; Svetlana Khakhina; Adriano De Bernardi Schneider; Michael V Callahan; Jill Glasspool-Malone; Robert Malone Journal: PLoS Negl Trop Dis Date: 2016-08-25
Authors: Elizabeth Centeno-Tablante; Melisa Medina-Rivera; Julia L Finkelstein; Heather S Herman; Pura Rayco-Solon; Maria Nieves Garcia-Casal; Lisa Rogers; Kate Ghezzi-Kopel; Mildred P Zambrano Leal; Joyce K Andrade Velasquez; Juan G Chang Asinc; Juan Pablo Peña-Rosas; Saurabh Mehta Journal: Viruses Date: 2021-01-18 Impact factor: 5.048
Authors: Annelies Wilder-Smith; Elizabeth B Brickley; Ricardo Arraes de Alencar Ximenes; Demócrito de Barros Miranda-Filho; Celina Maria Turchi Martelli; Tom Solomon; Bart C Jacobs; Carlos A Pardo; Lyda Osorio; Beatriz Parra; Suzannah Lant; Hugh J Willison; Sonja Leonhard; Lance Turtle; Maria Lúcia Brito Ferreira; Rafael Freitas de Oliveira Franca; Louis Lambrechts; Johan Neyts; Suzanne Kaptein; Rosanna Peeling; Deborah Boeras; James Logan; Helen Dolk; Ieda M Orioli; Andreas Neumayr; Trudie Lang; Bonny Baker; Eduardo Massad; Raman Preet Journal: Glob Health Action Date: 2021-10-26 Impact factor: 2.640
Authors: Giuseppe Gullo; Marco Scaglione; Gaspare Cucinella; Arianna Riva; Davide Coldebella; Anna Franca Cavaliere; Fabrizio Signore; Giovanni Buzzaccarini; Giulia Spagnol; Antonio Simone Laganà; Marco Noventa; Simona Zaami Journal: J Clin Med Date: 2022-03-01 Impact factor: 4.241
Authors: Leão Vhp; M M Aragão; R S Pinho; A N Hazin; A R Paciorkowski; A C Penalva de Oliveira; Marcelo Rodrigues Masruha Journal: Curr Neurol Neurosci Rep Date: 2020-09-03 Impact factor: 5.081