Literature DB >> 29209656

Ionic signalling and mitochondrial dynamics.

Nada Abuarab1, Fangfang Li1, Asipu Sivaprasadarao1,2.   

Abstract

In age-related diseases, rise in intracellular reactive oxygen species (ROS) causes fragmentation of mitochondrial network. Our recent study demonstrated that ROS activation of TRPM2 (transient receptor potential melastatin-2) channels triggers lysosomal Zn2+ release that, in turn, triggers mitochondrial fragmentation. The findings provide new mechanistic insights that may have therapeutic implications.

Entities:  

Keywords:  TRPM2; calcium; cell migration; cell proliferation; lysosomal membrane permeabilisation; mitochondrial dynamics; oxidative stress; reactive oxygen species; zinc

Year:  2017        PMID： 29209656      PMCID： PMC5706938          DOI： 10.1080/23723556.2017.1373889

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  Lysosomal membrane permeabilization in cell death: new evidence and implications for health and disease.

Authors:  Ana Serrano-Puebla; Patricia Boya
Journal:  Ann N Y Acad Sci       Date:  2015-11-24       Impact factor: 5.691

2.  Mitochondrial dynamics--mitochondrial fission and fusion in human diseases.

Authors:  Stephen L Archer
Journal:  N Engl J Med       Date:  2013-12-05       Impact factor: 91.245

Review 3.  Zinc in the physiology and pathology of the CNS.

Authors:  Stefano L Sensi; Pierre Paoletti; Ashley I Bush; Israel Sekler
Journal:  Nat Rev Neurosci       Date:  2009-10-14       Impact factor: 34.870

4.  TRPM2-mediated intracellular Zn2+ release triggers pancreatic β-cell death.

Authors:  Paul T Manna; Tim S Munsey; Nada Abuarab; Fangfang Li; Aruna Asipu; Gareth Howell; Alicia Sedo; Wei Yang; Jacqui Naylor; David J Beech; Lin-Hua Jiang; Asipu Sivaprasadarao
Journal:  Biochem J       Date:  2015-03-15       Impact factor: 3.857

5.  Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus.

Authors:  Sherene M Shenouda; Michael E Widlansky; Kai Chen; Guoquan Xu; Monika Holbrook; Corey E Tabit; Naomi M Hamburg; Alissa A Frame; Tara L Caiano; Matthew A Kluge; Mai-Ann Duess; Aaron Levit; Brian Kim; Mor-Li Hartman; Lija Joseph; Orian S Shirihai; Joseph A Vita
Journal:  Circulation       Date:  2011-07-11       Impact factor: 29.690

Review 6.  Mitochondrial Dynamics in Regulating the Unique Phenotypes of Cancer and Stem Cells.

Authors:  Hsiuchen Chen; David C Chan
Journal:  Cell Metab       Date:  2017-06-22       Impact factor: 27.287

7.  Novel role for the transient receptor potential channel TRPM2 in prostate cancer cell proliferation.

Authors:  X Zeng; S C Sikka; L Huang; C Sun; C Xu; D Jia; A B Abdel-Mageed; J E Pottle; J T Taylor; M Li
Journal:  Prostate Cancer Prostatic Dis       Date:  2009-12-22       Impact factor: 5.554

8.  Reciprocal regulation of actin cytoskeleton remodelling and cell migration by Ca2+ and Zn2+: role of TRPM2 channels.

Authors:  Fangfang Li; Nada Abuarab; Asipu Sivaprasadarao
Journal:  J Cell Sci       Date:  2016-04-11       Impact factor: 5.285

9.  High glucose-induced ROS activates TRPM2 to trigger lysosomal membrane permeabilization and Zn2+-mediated mitochondrial fission.

Authors:  Nada Abuarab; Tim S Munsey; Lin-Hua Jiang; Jing Li; Asipu Sivaprasadarao
Journal:  Sci Signal       Date:  2017-08-01       Impact factor: 8.192

10.  Mitochondrial dynamics regulates migration and invasion of breast cancer cells.

Authors:  J Zhao; J Zhang; M Yu; Y Xie; Y Huang; D W Wolff; P W Abel; Y Tu
Journal:  Oncogene       Date:  2012-11-05       Impact factor: 9.867
  10 in total

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