Literature DB >> 29209655

The E3 ubiquitin ligase STUB1 regulates autophagy and mitochondrial biogenesis by modulating TFEB activity.

Lang Rao1, Youbao Sha1, N Tony Eissa1.   

Abstract

TFEB is a master regulator for transcription of genes involved in autophagy, lysosome and mitochondrial biogenesis. Activity of TFEB is inhibited upon its phosphorylation. STUB1, a chaperone-dependent E3 ubiquitin ligase, modulates TFEB activity by preferentially targeting inactive phosphorylated TFEB for degradation by the ubiquitin proteasome pathway. Thus, the ubiquitin-proteasome pathway participates in regulating autophagy and lysosomal functions by regulating the activity of TFEB.

Entities:  

Keywords:  Autophagy; CHIP; STUB1; TFEB; proteasome; ubiquitin

Year:  2017        PMID： 29209655      PMCID： PMC5706942          DOI： 10.1080/23723556.2017.1372867

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  TFEB has DNA-binding and oligomerization properties of a unique helix-loop-helix/leucine-zipper family.

Authors:  D E Fisher; C S Carr; L A Parent; P A Sharp
Journal:  Genes Dev       Date:  1991-12       Impact factor: 11.361

2.  STUB1 regulates TFEB-induced autophagy-lysosome pathway.

Authors:  Youbao Sha; Lang Rao; Carmine Settembre; Andrea Ballabio; N Tony Eissa
Journal:  EMBO J       Date:  2017-07-28       Impact factor: 11.598

Review 3.  The Autophagy-Lysosomal Pathway in Neurodegeneration: A TFEB Perspective.

Authors:  Heidi Martini-Stoica; Yin Xu; Andrea Ballabio; Hui Zheng
Journal:  Trends Neurosci       Date:  2016-03-09       Impact factor: 13.837

4.  The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation.

Authors:  G C Meacham; C Patterson; W Zhang; J M Younger; D M Cyr
Journal:  Nat Cell Biol       Date:  2001-01       Impact factor: 28.824

5.  TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop.

Authors:  Carmine Settembre; Rossella De Cegli; Gelsomina Mansueto; Pradip K Saha; Francesco Vetrini; Orane Visvikis; Tuong Huynh; Annamaria Carissimo; Donna Palmer; Tiemo Jürgen Klisch; Amanda C Wollenberg; Diego Di Bernardo; Lawrence Chan; Javier E Irazoqui; Andrea Ballabio
Journal:  Nat Cell Biol       Date:  2013-04-21       Impact factor: 28.824

6.  A gene network regulating lysosomal biogenesis and function.

Authors:  Marco Sardiello; Michela Palmieri; Alberto di Ronza; Diego Luis Medina; Marta Valenza; Vincenzo Alessandro Gennarino; Chiara Di Malta; Francesca Donaudy; Valerio Embrione; Roman S Polishchuk; Sandro Banfi; Giancarlo Parenti; Elena Cattaneo; Andrea Ballabio
Journal:  Science       Date:  2009-06-25       Impact factor: 47.728

7.  TFEB links autophagy to lysosomal biogenesis.

Authors:  Carmine Settembre; Chiara Di Malta; Vinicia Assunta Polito; Moises Garcia Arencibia; Francesco Vetrini; Serkan Erdin; Serpil Uckac Erdin; Tuong Huynh; Diego Medina; Pasqualina Colella; Marco Sardiello; David C Rubinsztein; Andrea Ballabio
Journal:  Science       Date:  2011-05-26       Impact factor: 47.728

8.  Transcriptional activation of lysosomal exocytosis promotes cellular clearance.

Authors:  Diego L Medina; Alessandro Fraldi; Valentina Bouche; Fabio Annunziata; Gelsomina Mansueto; Carmine Spampanato; Claudia Puri; Antonella Pignata; Jose A Martina; Marco Sardiello; Michela Palmieri; Roman Polishchuk; Rosa Puertollano; Andrea Ballabio
Journal:  Dev Cell       Date:  2011-09-01       Impact factor: 12.270

9.  A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB.

Authors:  Carmine Settembre; Roberto Zoncu; Diego L Medina; Francesco Vetrini; Serkan Erdin; SerpilUckac Erdin; Tuong Huynh; Mathieu Ferron; Gerard Karsenty; Michel C Vellard; Valeria Facchinetti; David M Sabatini; Andrea Ballabio
Journal:  EMBO J       Date:  2012-02-17       Impact factor: 11.598

10.  Lysosomal calcium signalling regulates autophagy through calcineurin and ​TFEB.

Authors:  Diego L Medina; Simone Di Paola; Ivana Peluso; Andrea Armani; Diego De Stefani; Rossella Venditti; Sandro Montefusco; Anna Scotto-Rosato; Carolina Prezioso; Alison Forrester; Carmine Settembre; Wuyang Wang; Qiong Gao; Haoxing Xu; Marco Sandri; Rosario Rizzuto; Maria Antonietta De Matteis; Andrea Ballabio
Journal:  Nat Cell Biol       Date:  2015-03       Impact factor: 28.824
  10 in total
  9 in total

Review 1.  Autophagy in Pulmonary Innate Immunity.

Authors:  Lang Rao; N Tony Eissa
Journal:  J Innate Immun       Date:  2019-04-24       Impact factor: 7.349

Review 2.  Spinocerebellar ataxia type 48: last but not least.

Authors:  Giovanna De Michele; Daniele Galatolo; Melissa Barghigiani; Diletta Dello Iacovo; Rosanna Trovato; Alessandra Tessa; Elena Salvatore; Alessandro Filla; Giuseppe De Michele; Filippo M Santorelli
Journal:  Neurol Sci       Date:  2020-04-27       Impact factor: 3.307

3.  Adverse Effects of Fenofibrate in Mice Deficient in the Protein Quality Control Regulator, CHIP.

Authors:  Saranya Ravi; Traci L Parry; Monte S Willis; Pamela Lockyer; Cam Patterson; James R Bain; Robert D Stevens; Olga R Ilkayeva; Christopher B Newgard; Jonathan C Schisler
Journal:  J Cardiovasc Dev Dis       Date:  2018-08-15

Review 4.  The Classification of Autosomal Recessive Cerebellar Ataxias: a Consensus Statement from the Society for Research on the Cerebellum and Ataxias Task Force.

Authors:  Marie Beaudin; Antoni Matilla-Dueñas; Bing-Weng Soong; Jose Luiz Pedroso; Orlando G Barsottini; Hiroshi Mitoma; Shoji Tsuji; Jeremy D Schmahmann; Mario Manto; Guy A Rouleau; Christopher Klein; Nicolas Dupre
Journal:  Cerebellum       Date:  2019-12       Impact factor: 3.847

5.  mTOR hyperactivity mediates lysosomal dysfunction in Gaucher's disease iPSC-neuronal cells.

Authors:  Robert A Brown; Antanina Voit; Manasa P Srikanth; Julia A Thayer; Tami J Kingsbury; Marlene A Jacobson; Marta M Lipinski; Ricardo A Feldman; Ola Awad
Journal:  Dis Model Mech       Date:  2019-10-16       Impact factor: 5.758

Review 6.  The Regulation of MiTF/TFE Transcription Factors Across Model Organisms: from Brain Physiology to Implication for Neurodegeneration.

Authors:  Francesco Agostini; Rossella Agostinis; Diego L Medina; Marco Bisaglia; Elisa Greggio; Nicoletta Plotegher
Journal:  Mol Neurobiol       Date:  2022-06-04       Impact factor: 5.682

Review 7.  Emerging roles and regulation of MiT/TFE transcriptional factors.

Authors:  Min Yang; En Liu; Li Tang; Yuanyuan Lei; Xuemei Sun; Jiaxi Hu; Hui Dong; Shi-Ming Yang; Mingfa Gao; Bo Tang
Journal:  Cell Commun Signal       Date:  2018-06-15       Impact factor: 5.712

8.  C9orf72-associated SMCR8 protein binds in the ubiquitin pathway and with proteins linked with neurological disease.

Authors:  John L Goodier; Alisha O Soares; Gavin C Pereira; Lauren R DeVine; Laura Sanchez; Robert N Cole; Jose Luis García-Pérez
Journal:  Acta Neuropathol Commun       Date:  2020-07-16       Impact factor: 7.801

9.  SVIP alleviates CCl4-induced liver fibrosis via activating autophagy and protecting hepatocytes.

Authors:  Dan Jia; Yuan Yuan Wang; Pin Wang; Yao Huang; David Yuke Liang; Dongmei Wang; Chuandong Cheng; Caihua Zhang; Lianying Guo; Pin Liang; Yang Wang; Yujie Jia; Cong Li
Journal:  Cell Death Dis       Date:  2019-01-25       Impact factor: 8.469
  9 in total

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