Literature DB >> 29209645

Molecular pathways driven by ETO2-GLIS2 in aggressive pediatric leukemia.

Cécile Thirant1,2, Cécile Lopez1,2,3, Sébastien Malinge1,2,4, Thomas Mercher1,2,3,4,5.   

Abstract

The ETO2-GLIS2 fusion oncoprotein is associated with poor prognosis pediatric acute megakaryoblastic leukemia. Recently, we observed that ETO2-GLIS2 controls enhancers activity at genes regulating haematopoietic progenitor self-renewal and differentiation toward the megakaryocytic lineage. We also showed that targeting ETO2-GLIS2 complex stability inhibits these properties and may represent a novel therapeutic strategy.

Entities:  

Keywords:  AMKL; ERG; ETO2; GATA; GLIS2; NC128; enhancer; leukemia; transcription factor

Year:  2017        PMID： 29209645      PMCID： PMC5706939          DOI： 10.1080/23723556.2017.1345351

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

Review 1.  ETO interacting proteins.

Authors:  Bruce A Hug; Mitchell A Lazar
Journal:  Oncogene       Date:  2004-05-24       Impact factor: 9.867

Review 2.  Acute myeloid leukemia: a central role for the ETS factor ERG.

Authors:  Joost H A Martens
Journal:  Int J Biochem Cell Biol       Date:  2011-06-01       Impact factor: 5.085

Review 3.  The GATA factor revolution in hematology.

Authors:  Koichi R Katsumura; Emery H Bresnick
Journal:  Blood       Date:  2017-02-08       Impact factor: 22.113

4.  Super-enhancers in the control of cell identity and disease.

Authors:  Denes Hnisz; Brian J Abraham; Tong Ihn Lee; Ashley Lau; Violaine Saint-André; Alla A Sigova; Heather A Hoke; Richard A Young
Journal:  Cell       Date:  2013-10-10       Impact factor: 41.582

5.  ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia.

Authors:  Cécile Thirant; Cathy Ignacimouttou; Cécile K Lopez; M'Boyba Diop; Lou Le Mouël; Clarisse Thiollier; Aurélie Siret; Phillipe Dessen; Zakia Aid; Julie Rivière; Philippe Rameau; Céline Lefebvre; Mehdi Khaled; Guy Leverger; Paola Ballerini; Arnaud Petit; Hana Raslova; Catherine L Carmichael; Benjamin T Kile; Eric Soler; John D Crispino; Christian Wichmann; Françoise Pflumio; Jürg Schwaller; William Vainchenker; Camille Lobry; Nathalie Droin; Olivier A Bernard; Sébastien Malinge; Thomas Mercher
Journal:  Cancer Cell       Date:  2017-03-13       Impact factor: 31.743

Review 6.  Myeloid leukemia in Down syndrome.

Authors:  Irum Khan; Sébastien Malinge; John Crispino
Journal:  Crit Rev Oncog       Date:  2011

7.  RUNX1-ETO and RUNX1-EVI1 Differentially Reprogram the Chromatin Landscape in t(8;21) and t(3;21) AML.

Authors:  Justin Loke; Salam A Assi; Maria Rosaria Imperato; Anetta Ptasinska; Pierre Cauchy; Yura Grabovska; Natalia Martinez Soria; Manoj Raghavan; H Ruud Delwel; Peter N Cockerill; Olaf Heidenreich; Constanze Bonifer
Journal:  Cell Rep       Date:  2017-05-23       Impact factor: 9.423

8.  Transcription control by the ENL YEATS domain in acute leukaemia.

Authors:  Michael A Erb; Thomas G Scott; Bin E Li; Huafeng Xie; Joshiawa Paulk; Hyuk-Soo Seo; Amanda Souza; Justin M Roberts; Shiva Dastjerdi; Dennis L Buckley; Neville E Sanjana; Ophir Shalem; Behnam Nabet; Rhamy Zeid; Nana K Offei-Addo; Sirano Dhe-Paganon; Feng Zhang; Stuart H Orkin; Georg E Winter; James E Bradner
Journal:  Nature       Date:  2017-03-01       Impact factor: 49.962

9.  ENL links histone acetylation to oncogenic gene expression in acute myeloid leukaemia.

Authors:  Liling Wan; Hong Wen; Yuanyuan Li; Jie Lyu; Yuanxin Xi; Takayuki Hoshii; Julia K Joseph; Xiaolu Wang; Yong-Hwee E Loh; Michael A Erb; Amanda L Souza; James E Bradner; Li Shen; Wei Li; Haitao Li; C David Allis; Scott A Armstrong; Xiaobing Shi
Journal:  Nature       Date:  2017-03-01       Impact factor: 49.962

10.  Functional screen identifies regulators of murine hematopoietic stem cell repopulation.

Authors:  Per Holmfeldt; Miguel Ganuza; Himangi Marathe; Bing He; Trent Hall; Guolian Kang; Joseph Moen; Jennifer Pardieck; Angelica C Saulsberry; Alba Cico; Ludovic Gaut; Daniel McGoldrick; David Finkelstein; Kai Tan; Shannon McKinney-Freeman
Journal:  J Exp Med       Date:  2016-02-15       Impact factor: 14.307
  10 in total
  6 in total

Review 1.  The genomics of acute myeloid leukemia in children.

Authors:  Shannon E Conneely; Rachel E Rau
Journal:  Cancer Metastasis Rev       Date:  2020-03       Impact factor: 9.264

Review 2.  Emerging Roles of GLI-Similar Krüppel-like Zinc Finger Transcription Factors in Leukemia and Other Cancers.

Authors:  Anton M Jetten
Journal:  Trends Cancer       Date:  2019-08-20

Review 3.  GLIS1-3: Links to Primary Cilium, Reprogramming, Stem Cell Renewal, and Disease.

Authors:  Anton M Jetten; David W Scoville; Hong Soon Kang
Journal:  Cells       Date:  2022-06-03       Impact factor: 7.666

4.  GLIS2 redundancy causes chemoresistance and poor prognosis of gastric cancer based on co‑expression network analysis.

Authors:  Jingsheng Yuan; Lulu Tan; Zhijie Yin; Kaixiong Tao; Guobing Wang; Wenjia Shi; Jinbo Gao
Journal:  Oncol Rep       Date:  2018-10-15       Impact factor: 3.906

5.  Reduction of RUNX1 transcription factor activity by a CBFA2T3-mimicking peptide: application to B cell precursor acute lymphoblastic leukemia.

Authors:  Hélène Jakobczyk; Lydie Debaize; Benoit Soubise; Stéphane Avner; Jérémie Rouger-Gaudichon; Séverine Commet; Yan Jiang; Aurélien A Sérandour; Anne-Gaëlle Rio; Jason S Carroll; Christian Wichmann; Michael Lie-A-Ling; Georges Lacaud; Laurent Corcos; Gilles Salbert; Marie-Dominique Galibert; Virginie Gandemer; Marie-Bérengère Troadec
Journal:  J Hematol Oncol       Date:  2021-03-20       Impact factor: 17.388

Review 6.  CBFA2T3-GLIS2-positive acute myeloid leukaemia. A peculiar paediatric entity.

Authors:  Riccardo Masetti; Salvatore N Bertuccio; Andrea Pession; Franco Locatelli
Journal:  Br J Haematol       Date:  2018-12-28       Impact factor: 6.998
  6 in total

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