Literature DB >> 29209637

A role for p53 in telomere protection.

Stephen Tutton1, Paul M Lieberman1.   

Abstract

Telomeres cap the ends of chromosomes and are crucial for genome stability. The p53 protein (TP53) is a vital tumor suppressor, activating the transcription of numerous genes in response to cell stress. We reported that direct binding of p53 at human subtelomeres corresponds with local transcription activation and enhanced telomere stability in the presence of DNA damage.

Entities:  

Keywords:  Chromatin; DNA-damage; TERRA; TP53; eRNA; telomere; yH2AX

Year:  2016        PMID： 29209637      PMCID： PMC5706955          DOI： 10.1080/23723556.2016.1143078

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

1.  Cancer. p53, guardian of the genome.

Authors:  D P Lane
Journal:  Nature       Date:  1992-07-02       Impact factor: 49.962

2.  eRNAs are required for p53-dependent enhancer activity and gene transcription.

Authors:  Carlos A Melo; Jarno Drost; Patrick J Wijchers; Harmen van de Werken; Elzo de Wit; Joachim A F Oude Vrielink; Ran Elkon; Sónia A Melo; Nicolas Léveillé; Raghu Kalluri; Wouter de Laat; Reuven Agami
Journal:  Mol Cell       Date:  2012-12-27       Impact factor: 17.970

Review 3.  Telomere functions grounding on TERRA firma.

Authors:  Claus M Azzalin; Joachim Lingner
Journal:  Trends Cell Biol       Date:  2014-09-23       Impact factor: 20.808

4.  A comprehensive and high-resolution genome-wide response of p53 to stress.

Authors:  Gue Su Chang; Xiangyun Amy Chen; Bongsoo Park; Ho Sung Rhee; Pingxin Li; Kang Hoo Han; Tejaswini Mishra; Ka Yim Chan-Salis; Yunfei Li; Ross C Hardison; Yanming Wang; B Franklin Pugh
Journal:  Cell Rep       Date:  2014-07-17       Impact factor: 9.423

5.  Subtelomeric p53 binding prevents accumulation of DNA damage at human telomeres.

Authors:  Stephen Tutton; Greggory A Azzam; Nicholas Stong; Olga Vladimirova; Andreas Wiedmer; Jessica A Monteith; Kate Beishline; Zhuo Wang; Zhong Deng; Harold Riethman; Steven B McMahon; Maureen Murphy; Paul M Lieberman
Journal:  EMBO J       Date:  2015-12-12       Impact factor: 11.598

Review 6.  How shelterin protects mammalian telomeres.

Authors:  Wilhelm Palm; Titia de Lange
Journal:  Annu Rev Genet       Date:  2008       Impact factor: 16.830

7.  Unravelling mechanisms of p53-mediated tumour suppression.

Authors:  Kathryn T Bieging; Stephano Spano Mello; Laura D Attardi
Journal:  Nat Rev Cancer       Date:  2014-04-17       Impact factor: 60.716

8.  MLL associates with telomeres and regulates telomeric repeat-containing RNA transcription.

Authors:  Corrado Caslini; James A Connelly; Amparo Serna; Dominique Broccoli; Jay L Hess
Journal:  Mol Cell Biol       Date:  2009-06-15       Impact factor: 4.272

Review 9.  The replicometer is broken: telomeres activate cellular senescence in response to genotoxic stresses.

Authors:  Anitha Suram; Utz Herbig
Journal:  Aging Cell       Date:  2014-07-18       Impact factor: 9.304
  9 in total
  2 in total

1.  Elevated telomere dysfunction in cells containing the African-centric Pro47Ser cancer-risk variant of TP53.

Authors:  Stephen Tutton; Zhong Deng; Nitish Gulve; Olga Vladimirova; Kate Beishline; Andreas Wiedmer; Maureen Murphy; Paul M Lieberman
Journal:  Oncotarget       Date:  2019-06-04

2.  Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential.

Authors:  Tetsushi Nakao; Alexander G Bick; Margaret A Taub; Seyedeh M Zekavat; Md M Uddin; Abhishek Niroula; Cara L Carty; John Lane; Michael C Honigberg; Joshua S Weinstock; Akhil Pampana; Christopher J Gibson; Gabriel K Griffin; Shoa L Clarke; Romit Bhattacharya; Themistocles L Assimes; Leslie S Emery; Adrienne M Stilp; Quenna Wong; Jai Broome; Cecelia A Laurie; Alyna T Khan; Albert V Smith; Thomas W Blackwell; Veryan Codd; Christopher P Nelson; Zachary T Yoneda; Juan M Peralta; Donald W Bowden; Marguerite R Irvin; Meher Boorgula; Wei Zhao; Lisa R Yanek; Kerri L Wiggins; James E Hixson; C Charles Gu; Gina M Peloso; Dan M Roden; Muagututi'a S Reupena; Chii-Min Hwu; Dawn L DeMeo; Kari E North; Shannon Kelly; Solomon K Musani; Joshua C Bis; Donald M Lloyd-Jones; Jill M Johnsen; Michael Preuss; Russell P Tracy; Patricia A Peyser; Dandi Qiao; Pinkal Desai; Joanne E Curran; Barry I Freedman; Hemant K Tiwari; Sameer Chavan; Jennifer A Smith; Nicholas L Smith; Tanika N Kelly; Bertha Hidalgo; L Adrienne Cupples; Daniel E Weeks; Nicola L Hawley; Ryan L Minster; Ranjan Deka; Take T Naseri; Lisa de Las Fuentes; Laura M Raffield; Alanna C Morrison; Paul S Vries; Christie M Ballantyne; Eimear E Kenny; Stephen S Rich; Eric A Whitsel; Michael H Cho; M Benjamin Shoemaker; Betty S Pace; John Blangero; Nicholette D Palmer; Braxton D Mitchell; Alan R Shuldiner; Kathleen C Barnes; Susan Redline; Sharon L R Kardia; Gonçalo R Abecasis; Lewis C Becker; Susan R Heckbert; Jiang He; Wendy Post; Donna K Arnett; Ramachandran S Vasan; Dawood Darbar; Scott T Weiss; Stephen T McGarvey; Mariza de Andrade; Yii-Der Ida Chen; Robert C Kaplan; Deborah A Meyers; Brian S Custer; Adolfo Correa; Bruce M Psaty; Myriam Fornage; JoAnn E Manson; Eric Boerwinkle; Barbara A Konkle; Ruth J F Loos; Jerome I Rotter; Edwin K Silverman; Charles Kooperberg; John Danesh; Nilesh J Samani; Siddhartha Jaiswal; Peter Libby; Patrick T Ellinor; Nathan Pankratz; Benjamin L Ebert; Alexander P Reiner; Rasika A Mathias; Ron Do; Pradeep Natarajan
Journal:  Sci Adv       Date:  2022-04-06       Impact factor: 14.957
  2 in total

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