Literature DB >> 29209571

Complete regression of cutaneous metastases with systemic immune response in a patient with triple negative breast cancer receiving p53MVA vaccine with pembrolizumab.

Yuan Yuan1, Ferdynand J Kos2, Ting-Fang He3, Hongwei H Yin4, Mengsha Li5, Nicola Hardwick2, Kathryn Zurcher5, Daniel Schmolze4, Peter Lee3, Raju K Pillai4, Vincent Chung1, Don J Diamond2.   

Abstract

A heavily pretreated patient with triple negative breast cancer distinguished by cutaneous metastases received p53MVA vaccine in combination with pembrolizumab. Her cutaneous metastases regressed and after 2 cycles of therapy, a skin biopsy showed a complete pathological response. Systemic response was confirmed with restaging CT and bone scans. Activation of p53-specific T cell responses and elevation of multiple immune response genes in peripheral blood correlated with the rapid clinical response which lasted for 6 months after the initiation of combined therapy.

Entities:  

Keywords:  MVA; PD-1; T cell response; immunotherapy; p53; pembrolizumab; triple negative breast cancer; vaccine; vaccinia

Year:  2017        PMID： 29209571      PMCID： PMC5706612          DOI： 10.1080/2162402X.2017.1363138

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  20 in total

1.  p53MVA therapy in patients with refractory gastrointestinal malignancies elevates p53-specific CD8+ T-cell responses.

Authors:  Nicola R Hardwick; Mary Carroll; Teodora Kaltcheva; Dajun Qian; Dean Lim; Lucille Leong; Peiguo Chu; Joseph Kim; Joseph Chao; Marwan Fakih; Yun Yen; Jonathan Espenschied; Joshua D I Ellenhorn; Don J Diamond; Vincent Chung
Journal:  Clin Cancer Res       Date:  2014-07-01       Impact factor: 12.531

2.  Overcoming immunosuppression to enhance a p53MVA vaccine.

Authors:  Nicola Hardwick; Vincent Chung; Mihaela Cristea; Joshua DI Ellenhorn; Don J Diamond
Journal:  Oncoimmunology       Date:  2014-12-15       Impact factor: 8.110

3.  T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition.

Authors:  Enfu Hui; Jeanne Cheung; Jing Zhu; Xiaolei Su; Marcus J Taylor; Heidi A Wallweber; Dibyendu K Sasmal; Jun Huang; Jeong M Kim; Ira Mellman; Ronald D Vale
Journal:  Science       Date:  2017-03-09       Impact factor: 47.728

Review 4.  TP53 mutations in human cancers: origins, consequences, and clinical use.

Authors:  Magali Olivier; Monica Hollstein; Pierre Hainaut
Journal:  Cold Spring Harb Perspect Biol       Date:  2010-01       Impact factor: 10.005

Review 5.  Mutant p53: one name, many proteins.

Authors:  William A Freed-Pastor; Carol Prives
Journal:  Genes Dev       Date:  2012-06-15       Impact factor: 11.361

6.  The clonal and mutational evolution spectrum of primary triple-negative breast cancers.

Authors:  Sohrab P Shah; Andrew Roth; Rodrigo Goya; Arusha Oloumi; Gavin Ha; Yongjun Zhao; Gulisa Turashvili; Jiarui Ding; Kane Tse; Gholamreza Haffari; Ali Bashashati; Leah M Prentice; Jaswinder Khattra; Angela Burleigh; Damian Yap; Virginie Bernard; Andrew McPherson; Karey Shumansky; Anamaria Crisan; Ryan Giuliany; Alireza Heravi-Moussavi; Jamie Rosner; Daniel Lai; Inanc Birol; Richard Varhol; Angela Tam; Noreen Dhalla; Thomas Zeng; Kevin Ma; Simon K Chan; Malachi Griffith; Annie Moradian; S-W Grace Cheng; Gregg B Morin; Peter Watson; Karen Gelmon; Stephen Chia; Suet-Feung Chin; Christina Curtis; Oscar M Rueda; Paul D Pharoah; Sambasivarao Damaraju; John Mackey; Kelly Hoon; Timothy Harkins; Vasisht Tadigotla; Mahvash Sigaroudinia; Philippe Gascard; Thea Tlsty; Joseph F Costello; Irmtraud M Meyer; Connie J Eaves; Wyeth W Wasserman; Steven Jones; David Huntsman; Martin Hirst; Carlos Caldas; Marco A Marra; Samuel Aparicio
Journal:  Nature       Date:  2012-04-04       Impact factor: 49.962

Review 7.  Multiplexed immunohistochemistry, imaging, and quantitation: a review, with an assessment of Tyramide signal amplification, multispectral imaging and multiplex analysis.

Authors:  Edward C Stack; Chichung Wang; Kristin A Roman; Clifford C Hoyt
Journal:  Methods       Date:  2014-09-19       Impact factor: 3.608

Review 8.  Gene expression profiling in breast cancer: a clinical perspective.

Authors:  Grazia Arpino; Daniele Generali; Anna Sapino; Lucia Del Matro; Antonio Frassoldati; Michelino de Laurentis; Paolo Pronzato; Giorgio Mustacchi; Marina Cazzaniga; Sabino De Placido; Pierfranco Conte; Mariarosa Cappelletti; Vanessa Zanoni; Andrea Antonelli; Mario Martinotti; Fabio Puglisi; Alfredo Berruti; Alberto Bottini; Luigi Dogliotti
Journal:  Breast       Date:  2013-02-23       Impact factor: 4.380

9.  Differential response to neoadjuvant chemotherapy among 7 triple-negative breast cancer molecular subtypes.

Authors:  Hiroko Masuda; Keith A Baggerly; Ying Wang; Ya Zhang; Ana Maria Gonzalez-Angulo; Funda Meric-Bernstam; Vicente Valero; Brian D Lehmann; Jennifer A Pietenpol; Gabriel N Hortobagyi; W Fraser Symmans; Naoto T Ueno
Journal:  Clin Cancer Res       Date:  2013-08-15       Impact factor: 12.531

Review 10.  Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy.

Authors:  Suzanne L Topalian; Janis M Taube; Robert A Anders; Drew M Pardoll
Journal:  Nat Rev Cancer       Date:  2016-04-15       Impact factor: 60.716
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  10 in total

1.  p53-Reactive T Cells Are Associated with Clinical Benefit in Patients with Platinum-Resistant Epithelial Ovarian Cancer After Treatment with a p53 Vaccine and Gemcitabine Chemotherapy.

Authors:  Nicola R Hardwick; Paul Frankel; Christopher Ruel; Julie Kilpatrick; Weimin Tsai; Ferdynand Kos; Teodora Kaltcheva; Lucille Leong; Robert Morgan; Vincent Chung; Raechelle Tinsley; Melissa Eng; Sharon Wilczynski; Joshua D I Ellenhorn; Don J Diamond; Mihaela Cristea
Journal:  Clin Cancer Res       Date:  2018-01-04       Impact factor: 12.531

Review 2.  Combining vaccines and immune checkpoint inhibitors to prime, expand, and facilitate effective tumor immunotherapy.

Authors:  Julie M Collins; Jason M Redman; James L Gulley
Journal:  Expert Rev Vaccines       Date:  2018-08-22       Impact factor: 5.217

Review 3.  Trial Watch: Immunostimulation with recombinant cytokines for cancer therapy.

Authors:  Elena García-Martínez; Melody Smith; Aitziber Buqué; Fernando Aranda; Francisco Ayala de la Peña; Alejandra Ivars; Manuel Sanchez Cánovas; Ma Angeles Vicente Conesa; Jitka Fucikova; Radek Spisek; Laurence Zitvogel; Guido Kroemer; Lorenzo Galluzzi
Journal:  Oncoimmunology       Date:  2018-02-15       Impact factor: 8.110

4.  COH04S1 and beta sequence-modified vaccine protect hamsters from SARS-CoV-2 variants.

Authors:  Felix Wussow; Mindy Kha; Katelyn Faircloth; Vu H Nguyen; Angelina Iniguez; Joy Martinez; Yoonsuh Park; Jenny Nguyen; Swagata Kar; Hanne Andersen; Mark G Lewis; Flavia Chiuppesi; Don J Diamond
Journal:  iScience       Date:  2022-05-23

5.  Evaluation of safety and efficacy of p53MVA vaccine combined with pembrolizumab in patients with advanced solid cancers.

Authors:  V Chung; F J Kos; N Hardwick; Y Yuan; J Chao; D Li; J Waisman; M Li; K Zurcher; P Frankel; D J Diamond
Journal:  Clin Transl Oncol       Date:  2018-08-09       Impact factor: 3.340

6.  Development of a Multi-Antigenic SARS-CoV-2 Vaccine Using a Synthetic Poxvirus Platform.

Authors:  Flavia Chiuppesi; Marcela d'Alincourt Salazar; Heidi Contreras; Vu Nguyen; Joy Martinez; Soojin Park; Jenny Nguyen; Mindy Kha; Angelina Iniguez; Qiao Zhou; Teodora Kaltcheva; Roman Levytskyy; Nancy Ebelt; Tae Kang; Xiwei Wu; Tom Rogers; Edwin Manuel; Yuriy Shostak; Don Diamond; Felix Wussow
Journal:  Res Sq       Date:  2020-07-17

7.  Development of a Synthetic Poxvirus-Based SARS-CoV-2 Vaccine.

Authors:  Flavia Chiuppesi; Marcela d'Alincourt Salazar; Heidi Contreras; Vu H Nguyen; Joy Martinez; Soojin Park; Jenny Nguyen; Mindy Kha; Angelina Iniguez; Qiao Zhou; Teodora Kaltcheva; Roman Levytskyy; Nancy D Ebelt; Tae Hyuk Kang; Xiwei Wu; Thomas Rogers; Edwin R Manuel; Yuriy Shostak; Don J Diamond; Felix Wussow
Journal:  bioRxiv       Date:  2020-07-02

8.  Development of a multi-antigenic SARS-CoV-2 vaccine candidate using a synthetic poxvirus platform.

Authors:  Flavia Chiuppesi; Marcela d'Alincourt Salazar; Heidi Contreras; Vu H Nguyen; Joy Martinez; Yoonsuh Park; Jenny Nguyen; Mindy Kha; Angelina Iniguez; Qiao Zhou; Teodora Kaltcheva; Roman Levytskyy; Nancy D Ebelt; Tae Hyuk Kang; Xiwei Wu; Thomas F Rogers; Edwin R Manuel; Yuriy Shostak; Don J Diamond; Felix Wussow
Journal:  Nat Commun       Date:  2020-11-30       Impact factor: 14.919

Review 9.  Cutaneous metastasectomy: Is there a role in breast cancer? A systematic review and overview of current treatment modalities.

Authors:  Samantha Huang; Vishwas Parekh; James Waisman; Veronica Jones; Yuan Yuan; Nayana Vora; Richard Li; Jae Jung; Laura Kruper; Farah Abdulla; Yuman Fong; Wai-Yee Li
Journal:  J Surg Oncol       Date:  2022-04-07       Impact factor: 2.885

10.  Synthetic multiantigen MVA vaccine COH04S1 protects against SARS-CoV-2 in Syrian hamsters and non-human primates.

Authors:  Flavia Chiuppesi; Vu H Nguyen; Yoonsuh Park; Heidi Contreras; Veronica Karpinski; Katelyn Faircloth; Jenny Nguyen; Mindy Kha; Daisy Johnson; Joy Martinez; Angelina Iniguez; Qiao Zhou; Teodora Kaltcheva; Paul Frankel; Swagata Kar; Ankur Sharma; Hanne Andersen; Mark G Lewis; Yuriy Shostak; Felix Wussow; Don J Diamond
Journal:  NPJ Vaccines       Date:  2022-01-21       Impact factor: 9.399
  10 in total

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