Edward Mullins1, Christoph Lees2,3, Peter Brocklehurst4. 1. Imperial College London, London, UK. 2. Imperial College London, London, UK c.lees@imperial.ac.uk p.brocklehurst@bham.ac.uk. 3. Department of Development and Regeneration, KU Leuven, Belgium. 4. Birmingham Clinical Trials Unit, Institute of Applied Health Research, University of Birmingham, Birmingham, UK c.lees@imperial.ac.uk p.brocklehurst@bham.ac.uk.