| Literature DB >> 29208486 |
Beatriz Martínez-Pérez1, David Quintanar-Guerrero2, Melina Tapia-Tapia3, Ricardo Cisneros-Tamayo4, María L Zambrano-Zaragoza5, Sergio Alcalá-Alcalá6, Néstor Mendoza-Muñoz7, Elizabeth Piñón-Segundo8.
Abstract
This study aimed to prepare poly (d,l-lactide-co-glycolide) (PLGA) nanoparticles (NPs) with chitosan (CTS) surface modification to be used as a vaginal delivery system for antimycotic drugs. Clotrimazole was encapsulated with entrapment efficiencies of 86.1 and 68.9% into Clotrimazole-PLGA-NPs (CLT-PLGA-NPs) and PLGA-NPs with CTS-modified surface (CLT-PLGA-CTS-NPs), respectively. The later NPs exhibited a larger size and higher positive zeta potential (Z potential) in comparison to unmodified NPs. In vitro release kinetic studies indicated that Clotrimazole was released in percentages of >98% from both nanoparticulate systems after 18days. Antifungal activity and mucoadhesive properties of NPs were enhanced when CTS was added onto the surface. In summary, these results suggested that Clotrimazole loaded into PLGA-CTS-NPs has great potential for vaginal applications in treating vaginal infections generated by Candida albicans.Entities:
Keywords: Biodegradable nanoparticles; Clotrimazole; Clotrimazole (PubChem CID: 2812); Mucoadhesion; PLGA–chitosan nanoparticles; Vaginal administration
Mesh：
Substances：
Year: 2017 PMID： 29208486 DOI： 10.1016/j.ejps.2017.11.029
Source DB: PubMed Journal: Eur J Pharm Sci ISSN： 0928-0987 Impact factor: 4.384