J R Young1, I Orosz2, M A Franke2, H J Kim2, D Woodworth2, B M Ellingson2, N Salamon2, W B Pope3. 1. Department of Radiology, UC Davis School of Medicine, 4860 Y. Street, Suite #3100, Sacramento, CA 95817, USA; Department of Radiological Sciences, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, 1621E, Los Angeles, CA 90095, USA. 2. Department of Radiological Sciences, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, 1621E, Los Angeles, CA 90095, USA. 3. Department of Radiological Sciences, David Geffen School of Medicine at UCLA, 757 Westwood Plaza, 1621E, Los Angeles, CA 90095, USA. Electronic address: wpope@mednet.ucla.edu.
Abstract
AIM: To determine whether repeated gadolinium-based contrast agent administration (GBCA) in children is associated with the development of increased T1-weighted signal intensity within the cerebellar dentate nucleus. MATERIALS AND METHODS: With institutional review board approval for this The Health Insurance Portability and Accountability Act-compliant retrospective study, a cohort of 41 patients under the age of 18 years who underwent at least four contrast-enhanced magnetic resonance imaging (MR) examinations of the brain from 2005 to 2015 were identified. For each examination, both dentate nuclei were manually contoured, and the mean dentate nucleus-to-pons signal intensity (DN-P SI) ratio was calculated. The DN-P SI ratios from the last to first MRI examination were compared, and the correlation between DN-P SI ratio and cumulative gadolinium dose was calculated using a linear mixed effect model to control for potentially confounding variables. RESULTS: For the 41 patients in the cohort, there was a significant increase in the mean DN-P SI ratio from the first MRI to the last MRI examination (1.05 versus 1.11, p=0.004). After controlling for patient diagnosis, history of chemotherapy or radiation, sex, and age, there was a significant positive association between DN-P SI ratio and cumulative gadolinium dose (coefficient=0.401, p=0.032). CONCLUSION: Repeated GBCA administration in children is associated with increased T1-weighted signal intensity within the dentate nucleus.
AIM: To determine whether repeated gadolinium-based contrast agent administration (GBCA) in children is associated with the development of increased T1-weighted signal intensity within the cerebellar dentate nucleus. MATERIALS AND METHODS: With institutional review board approval for this The Health Insurance Portability and Accountability Act-compliant retrospective study, a cohort of 41 patients under the age of 18 years who underwent at least four contrast-enhanced magnetic resonance imaging (MR) examinations of the brain from 2005 to 2015 were identified. For each examination, both dentate nuclei were manually contoured, and the mean dentate nucleus-to-pons signal intensity (DN-P SI) ratio was calculated. The DN-P SI ratios from the last to first MRI examination were compared, and the correlation between DN-P SI ratio and cumulative gadolinium dose was calculated using a linear mixed effect model to control for potentially confounding variables. RESULTS: For the 41 patients in the cohort, there was a significant increase in the mean DN-P SI ratio from the first MRI to the last MRI examination (1.05 versus 1.11, p=0.004). After controlling for patient diagnosis, history of chemotherapy or radiation, sex, and age, there was a significant positive association between DN-P SI ratio and cumulative gadolinium dose (coefficient=0.401, p=0.032). CONCLUSION: Repeated GBCA administration in children is associated with increased T1-weighted signal intensity within the dentate nucleus.
Authors: Carlo C Quattrocchi; Joana Ramalho; Aart J van der Molen; Àlex Rovira; Alexander Radbruch Journal: Eur Radiol Date: 2018-11-09 Impact factor: 5.315
Authors: Jonathan R Young; Joe Qiao; Iren Orosz; Noriko Salamon; Mark A Franke; Hyun J Kim; Whitney B Pope Journal: Eur Radiol Date: 2018-05-09 Impact factor: 5.315
Authors: Bernadette B L J Elders; Sergei M Hermelijn; Harm A W M Tiddens; Bas Pullens; Pjotr A Wielopolski; Pierluigi Ciet Journal: Pediatr Pulmonol Date: 2019-01-25