Yao Li1, Yongda Lu1, Jiaqing Shen2, Chunfang Xu3. 1. Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. 2. Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. Electronic address: sjqsz@126.com. 3. Department of Gastroenterology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. Electronic address: xcf003@126.com.
Abstract
BACKGROUND: Midkine (MK) is reported to be involved in the pathogenesis of numerous pathologies, but the expression of MK in acute pancreatitis (AP) has not been well studied and documented. METHODS: In this study, the temporal changes of serum MK were assessed in 97 patients with AP by enzyme-linked immunosorbent assay. RESULTS: The concentration of serum MK increased along with the severity of AP. Serum MK level increased more significantly in patients with organ failure than in those without organ failure. A more obvious elevation of serum MK level was also observed in patients with pancreatic necrosis. CONCLUSION: Serum MK might be a useful marker in the clinical diagnosis of AP.
BACKGROUND:Midkine (MK) is reported to be involved in the pathogenesis of numerous pathologies, but the expression of MK in acute pancreatitis (AP) has not been well studied and documented. METHODS: In this study, the temporal changes of serum MK were assessed in 97 patients with AP by enzyme-linked immunosorbent assay. RESULTS: The concentration of serum MK increased along with the severity of AP. Serum MK level increased more significantly in patients with organ failure than in those without organ failure. A more obvious elevation of serum MK level was also observed in patients with pancreatic necrosis. CONCLUSION: Serum MK might be a useful marker in the clinical diagnosis of AP.
Authors: Emese Réka Bálint; Gabriella Fűr; Lóránd Kiss; Dávid István Németh; Alexandra Soós; Péter Hegyi; Zsolt Szakács; Benedek Tinusz; Péter Varjú; Áron Vincze; Bálint Erőss; József Czimmer; Zoltán Szepes; Gábor Varga; Zoltán Rakonczay Journal: Sci Rep Date: 2020-10-21 Impact factor: 4.379