Literature DB >> 29207788

Hyperparathyroidism during Pregnancy- A Diagnostic and Therapeutic Challenge.

Richa Sharma1, Vishnu Bhartiya2, Kiran Guleria3, Amita Suneja4.   

Abstract

Primary Hyperparathyroidism (PHP) is a rare event in pregnancy; Maternal complications in PHP patients can be as high as 67%. It can be overlooked easily because of many similar complaints shared by hyperparathyroidism and pregnancy such as nausea and vomiting, gastritis, bone aches, easy fatigability. Hypercalcemic crisis can develop resulting in coma and death. Neonatal effects are tetany and death in about 80% of cases. We report a case, of an antenatal woman at 30 weeks gestation with complains of painful swelling in left lower jaw and below right knee, pain over right hip joint and frequent episodes of gastritis. She was finally diagnosed to have primary hyperparathyroidism and brown tumour due to parathyroid adenoma. The baby was kept in Neonatal Intensive Care Unit (NICU) for three weeks, in view of prematurity with respiratory distress and later developed sepsis with DIC. The patient's signs and symptoms regressed after parathyroid surgery and the baby was healthy at the time of discharge. This case highlights the progressive deterioration of the patient because of lack of awareness of this disease process and its impact on maternal and foetal morbidity.

Entities:  

Keywords:  Expansile tumour; Hypercalcemic crisis; Osteolytic lesions

Year:  2017        PMID: 29207788      PMCID: PMC5713810          DOI: 10.7860/JCDR/2017/25948.10688

Source DB:  PubMed          Journal:  J Clin Diagn Res        ISSN: 0973-709X


  17 in total

Review 1.  Hyperparathyroidism and pregnancy.

Authors:  K C Kort; H J Schiller; P J Numann
Journal:  Am J Surg       Date:  1999-01       Impact factor: 2.565

Review 2.  Brown tumors of the jaws associated with primary or secondary hyperparathyroidism. A clinical study and review of the literature.

Authors:  Katherine Triantafillidou; Lambros Zouloumis; George Karakinaris; Elettherios Kalimeras; Fotis Iordanidis
Journal:  Am J Otolaryngol       Date:  2006 Jul-Aug       Impact factor: 1.808

3.  Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the third international workshop.

Authors:  John P Bilezikian; Aliya A Khan; John T Potts
Journal:  J Clin Endocrinol Metab       Date:  2009-02       Impact factor: 5.958

4.  Primary hyperparathyroidism: changes on biochemical and hormonal profile related to pregnancy.

Authors:  J M Lopez; C B Fardella
Journal:  J Endocrinol Invest       Date:  1989-02       Impact factor: 4.256

5.  Hyperparathyroidism presenting as brown tumor of the maxilla.

Authors:  Meredith N Merz; Douglas D Massich; William Marsh; David E Schuller
Journal:  Am J Otolaryngol       Date:  2002 May-Jun       Impact factor: 1.808

Review 6.  Primary hyperparathyroidism.

Authors:  Erin A Felger; Emad Kandil
Journal:  Otolaryngol Clin North Am       Date:  2010-04       Impact factor: 3.346

7.  Surgical approach and clinical outcome of a deforming brown tumor at the maxilla in a patient with secondary hyperparathyroidism due to chronic renal failure.

Authors:  Christianne T S Leal; Paulo G S Lacativa; Elaine M S Gomes; Reinaldo C Nunes; Flávio Luiz F de S Costa; Italo H A Gandelmann; Maria A A Cavalcante; Maria Lucia F Farias
Journal:  Arq Bras Endocrinol Metabol       Date:  2006-10

Review 8.  Primary hyperparathyroidism in pregnancy: evidence-based management.

Authors:  Peter F Schnatz; Stephen L Curry
Journal:  Obstet Gynecol Surv       Date:  2002-06       Impact factor: 2.347

Review 9.  Hyperparathyroidism and pregnancy: case report and review.

Authors:  M J Carella; V V Gossain
Journal:  J Gen Intern Med       Date:  1992 Jul-Aug       Impact factor: 5.128

Review 10.  Primary hyperparathyroidism during pregnancy.

Authors:  T R Kelly
Journal:  Surgery       Date:  1991-12       Impact factor: 3.982

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