Pallavi Shantkumar Kanthe1, Bheemshetty S Patil2, Shrilaxmi C Bagali3, R Chandramouli Reddy4, Manjunatha R Aithala5, Kusal K Das6. 1. PhD Scholar, Department of Laboratory of Vascular Physiology and Medicine, Department of Physiology, BLDE University Shri B. M. Patil Medical College, Hospital and Research Centre, Vijayapura, Karnataka, India. 2. Lecturer, Department of Anatomy, BLDE University Shri B. M. Patil Medical College, Hospital and Research Centre, Vijayapura, Karnataka, India. 3. Assistant Professor, Department of Laboratory of Vascular Physiology and Medicine, Department of Physiology, BLDE University Shri B. M. Patil Medical College, Hospital and Research Centre, Vijayapura, Karnataka, India. 4. Junior Research Scientist, Department of Laboratory of Vascular Physiology and Medicine, Department of Physiology, BLDE University Shri B. M. Patil Medical College, Hospital and Research Centre, Vijayapura, Karnataka, India. 5. Professor and Head, Department of Physiology, BLDE University Shri B. M. Patil Medical College, Hospital and Research Centre, Vijayapura, Karnataka, India. 6. Professor, Department of Laboratory of Vascular Physiology and Medicine, Department of Physiology, BLDE University Shri B. M. Patil Medical College, Hospital and Research Centre, Vijayapura, Karnataka, India.
Abstract
INTRODUCTION: Dietary high fat alters lipid profile and possibly induce sympatho-vagal imbalance. Emblica officinalis is found to be potential antioxidant and possibly counteract hyperlipidemia induced lipid peroxidation. AIM: To assess Ethanolic extract of Emblica Officinalis (EEO) as lipid lowering and cardiovascular protective agent against high dietary fat supplemented to experimental rats. Further to study a comparative analysis between EEO and atorvastatin on hyperlipidemia and cardiovascular integrity. MATERIALS AND METHODS: EEO was prepared and phytochemical analysis was done. Rats were divided into five groups, having six rats in each group as following; Group I-control (20% fat); Group II (+ EEO 100 mg/kg body wt); Group III (fed with high fat diet; 30% fat); Group IV (fed with high fat diet; 30% fat + EEO 100 mg/kg body wt) and Group V (fed with high fat diet; 30% fat + atorvastatin 4 mg/kg body wt). The treatments were continued for 21 days. Gravimetric parameters and electrophysiological parameters {Heart Rate (HR), sympatho-vagal balance} were recorded and lipid profiles of all the groups were measured. ANOVA, correlation and multiple regressions were done for analysis of data. RESULTS: Significant alteration in serum lipid profile was observed in rats fed with high dietary fat but supplementation of EEO was found to be reversible. Electrophysiological evaluation revealed altered HR and sympatho-vagal balance in high dietary fat fed rats (Group III) which indicate cardiac autonomic malfunctions which were found to be improved in Emblica officinalis supplemented group of rats (Group IV). Further, analysis has shown significant negative correlation between HDL/LDL and sympatho-vagal balance in all groups of rats which clearly indicate a role of dietary fat on sympatho-vagal balance. These results further corroborated with findings of histopathological study on myocardium and elastic artery. CONCLUSION: Observations from the study indicate a beneficial role of ethanolic extract of Emblica officinalis (amla) on dyslipidemia and cardiac autonomic functions in rats treated with high fat diet.
INTRODUCTION: Dietary high fat alters lipid profile and possibly induce sympatho-vagal imbalance. Emblica officinalis is found to be potential antioxidant and possibly counteract hyperlipidemia induced lipid peroxidation. AIM: To assess Ethanolic extract of Emblica Officinalis (EEO) as lipid lowering and cardiovascular protective agent against high dietary fat supplemented to experimental rats. Further to study a comparative analysis between EEO and atorvastatin on hyperlipidemia and cardiovascular integrity. MATERIALS AND METHODS: EEO was prepared and phytochemical analysis was done. Rats were divided into five groups, having six rats in each group as following; Group I-control (20% fat); Group II (+ EEO 100 mg/kg body wt); Group III (fed with high fat diet; 30% fat); Group IV (fed with high fat diet; 30% fat + EEO 100 mg/kg body wt) and Group V (fed with high fat diet; 30% fat + atorvastatin 4 mg/kg body wt). The treatments were continued for 21 days. Gravimetric parameters and electrophysiological parameters {Heart Rate (HR), sympatho-vagal balance} were recorded and lipid profiles of all the groups were measured. ANOVA, correlation and multiple regressions were done for analysis of data. RESULTS: Significant alteration in serum lipid profile was observed in rats fed with high dietary fat but supplementation of EEO was found to be reversible. Electrophysiological evaluation revealed altered HR and sympatho-vagal balance in high dietary fat fed rats (Group III) which indicate cardiac autonomic malfunctions which were found to be improved in Emblica officinalis supplemented group of rats (Group IV). Further, analysis has shown significant negative correlation between HDL/LDL and sympatho-vagal balance in all groups of rats which clearly indicate a role of dietary fat on sympatho-vagal balance. These results further corroborated with findings of histopathological study on myocardium and elastic artery. CONCLUSION: Observations from the study indicate a beneficial role of ethanolic extract of Emblica officinalis (amla) on dyslipidemia and cardiac autonomic functions in rats treated with high fat diet.
Entities:
Keywords:
Atorvastatin high fat diet; Lipid profile; Sympatho-vagal balance
Authors: Emiliano Medei; Ana Paula Lima-Leopoldo; Pedro Paulo Pereira-Junior; André Soares Leopoldo; Dijon Henrique Salomé Campos; Juliana Montani Raimundo; Roberto Takashi Sudo; Gisele Zapata-Sudo; Thiago Bruder-Nascimento; Sandra Cordellini; José Hamilton Matheus Nascimento; Antonio Carlos Cicogna Journal: Can J Cardiol Date: 2010-12 Impact factor: 5.223
Authors: Maryam Gul; Zhi-Wei Liu; Roshina Rabail; Fatima Faheem; Noman Walayat; Asad Nawaz; Muhammad Asim Shabbir; Paulo E S Munekata; José M Lorenzo; Rana Muhammad Aadil Journal: Antioxidants (Basel) Date: 2022-04-22