Abid K Shaheer1, Jithesh K Tharayil2, Parvathi W Krishna3. 1. Postgraduate Student, Department of Biochemistry, School of Health Sciences, University of Calicut, Malappuram, Kerala, India. 2. Associate Professor, Department of Biochemistry, MES Medical College, Perinthalmanna, Kerala, India. 3. Professor and Head, Department of Biochemistry, MES Medical College, Perinthalmanna, Kerala, India.
Abstract
INTRODUCTION: Diabetic nephropathy is a serious chronic complication of Type 2 Diabetes Mellitus (T2DM) which impairs the quality of life, leading to increased morbidity and mortality. The high sensitivity C-reactive protein (hs-CRP) is an acute phase reactant which acts as a non-specific systemic marker of inflammation. AIM: To find out the relationship between serum hs-CRP and metabolic variables in Type 2 diabetic patients with and without nephropathy. MATERIALS AND METHODS: The study group consists of 96 subjects that include non-diabetic healthy controls, Type 2 diabetic patients without any complications and patients with diabetic nephropathy. The study group was composed of both genders, aged 31-70 years, who reported after 10-12 hours overnight fasting; then, venous blood and fresh urine samples were collected, in the morning from all the study subjects. Data were analysed using Statistical Package for the Social Sciences (SPSS). Independent t-test was used to compare between the groups and Chi square test was used to find out the relationship between serum hs-CRP and metabolic variables. RESULTS: The results showed a significantly (p<0.05) increasing trend of serum hs-CRP with the degree of microalbumin excretion and the severity of nephropathy in Type 2 diabetic patients. The result showed a significant (p<0.05) relationship between hs-CRP and the metabolic variables like Fasting Blood Glucose (FBG), Post Prandial Blood Glucose (PPBG), Total Cholesterol (TC), Triglycerides (TG), LDL-Cholesterol (LDL-C), TC:HDL-Cholesterol (HDL-C) ratio and estimated Glomerular Filtration Rate (eGFR) and no significance (p>0.05) between hs-CRP and HDL-Cholesterol in both diabetic and diabetic nephropathy subjects. CONCLUSION: Hs-CRP was strongly associated with the metabolic variables and predictors of cardiovascular risk in Type 2 diabetes mellitus with and without nephropathy. The hs-CRP might be considered as a predictor or illness indicator for the development of nephropathy and cardiovascular risk in Type 2 diabetic patients.
INTRODUCTION: Diabetic nephropathy is a serious chronic complication of Type 2 Diabetes Mellitus (T2DM) which impairs the quality of life, leading to increased morbidity and mortality. The high sensitivity C-reactive protein (hs-CRP) is an acute phase reactant which acts as a non-specific systemic marker of inflammation. AIM: To find out the relationship between serum hs-CRP and metabolic variables in Type 2 diabetic patients with and without nephropathy. MATERIALS AND METHODS: The study group consists of 96 subjects that include non-diabetic healthy controls, Type 2 diabetic patients without any complications and patients with diabetic nephropathy. The study group was composed of both genders, aged 31-70 years, who reported after 10-12 hours overnight fasting; then, venous blood and fresh urine samples were collected, in the morning from all the study subjects. Data were analysed using Statistical Package for the Social Sciences (SPSS). Independent t-test was used to compare between the groups and Chi square test was used to find out the relationship between serum hs-CRP and metabolic variables. RESULTS: The results showed a significantly (p<0.05) increasing trend of serum hs-CRP with the degree of microalbumin excretion and the severity of nephropathy in Type 2 diabetic patients. The result showed a significant (p<0.05) relationship between hs-CRP and the metabolic variables like Fasting Blood Glucose (FBG), Post Prandial Blood Glucose (PPBG), Total Cholesterol (TC), Triglycerides (TG), LDL-Cholesterol (LDL-C), TC:HDL-Cholesterol (HDL-C) ratio and estimated Glomerular Filtration Rate (eGFR) and no significance (p>0.05) between hs-CRP and HDL-Cholesterol in both diabetic and diabetic nephropathy subjects. CONCLUSION: Hs-CRP was strongly associated with the metabolic variables and predictors of cardiovascular risk in Type 2 diabetes mellitus with and without nephropathy. The hs-CRP might be considered as a predictor or illness indicator for the development of nephropathy and cardiovascular risk in Type 2 diabetic patients.
Authors: Ranil Jayawardena; Priyanga Ranasinghe; Nuala M Byrne; Mario J Soares; Prasad Katulanda; Andrew P Hills Journal: BMC Public Health Date: 2012-05-25 Impact factor: 3.295
Authors: Tamil Selvi Loganathan; Siti Aishah Sulaiman; Nor Azian Abdul Murad; Shamsul Azhar Shah; Abdul Halim Abdul Gafor; Rahman Jamal; Noraidatulakma Abdullah Journal: Front Pharmacol Date: 2020-03-03 Impact factor: 5.810