| Literature DB >> 29205950 |
Nikhil Pandey1,2, Amirhossein Hakamivala1,2, Cancan Xu1,2, Prashant Hariharan1,2, Boris Radionov1,2, Zhong Huang1, Jun Liao1,2, Liping Tang1,2, Philippe Zimmern3, Kytai T Nguyen1,2, Yi Hong1,2.
Abstract
Popular bioadhesives, such as fibrin, cyanoacrylate, and albumin-glutaraldehyde based materials, have been applied for clinical applications in wound healing, drug delivery, and bone and soft tissue engineering; however, their performances are limited by weak adhesion strength and rapid degradation. In this study a mussel-inspired, nanocomposite-based, biodegradable tissue adhesive is developed by blending poly(lactic-co-glycolic acid) (PLGA) or N-hydroxysuccinimide modified PLGA nanoparticles (PLGA-NHS) with mussel-inspired alginate-dopamine polymer (Alg-Dopa). Adhesive strength measurement of the nanocomposites on porcine skin-muscle constructs reveals that the incorporation of nanoparticles in Alg-Dopa significantly enhances the tissue adhesive strength compared to the mussel-inspired adhesive alone. The nanocomposite formed by PLGA-NHS nanoparticles shows higher lap shear strength of 33 ± 3 kPa, compared to that of Alg-Dopa hydrogel alone (14 ± 2 kPa). In addition, these nanocomposites are degradable and cytocompatible in vitro, and elicit in vivo minimal inflammatory responses in a rat model, suggesting clinical potential of these nanocomposites as bioadhesives.Entities:
Keywords: bioadhesives; nanocomposites; nanoparticles; tissue adhesion; tissue interfaces
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Year: 2017 PMID： 29205950 PMCID： PMC5902656 DOI： 10.1002/adhm.201701069
Source DB: PubMed Journal: Adv Healthc Mater ISSN： 2192-2640 Impact factor: 9.933