Suat Kılıç1, Ruwaa Samarrai1, Sarah S Kılıç2, Mina Mikhael1, Soly Baredes1,3, Jean Anderson Eloy1,3,4,5. 1. a Department of Otolaryngology - Head and Neck Surgery , Rutgers New Jersey Medical School , Newark , NJ , USA. 2. b Department of Radiation Oncology , Rutgers New Jersey Medical School , Newark , NJ , USA. 3. c Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey , Rutgers New Jersey Medical School , Newark , NJ , USA. 4. d Department of Neurological Surgery , Rutgers New Jersey Medical School , Newark , NJ , USA. 5. e Department of Ophthalmology and Visual Science , Rutgers New Jersey Medical School , Newark , NJ , USA.
Abstract
OBJECTIVE: To determine the incidence and survival of sinonasal adenocarcinoma (SNAC) by subsite and histologic subtype. STUDY DESIGN: Retrospective database review. METHODS: Using the SEER database, we performed a retrospective analysis, identified cases of SNAC diagnosed between 1973 and 2013 and analyzed demographic, histopathology, clinicopathology, and determinants of disease specific survival (DSS). RESULTS: A total of 746 patients with SNAC were identified. Median age at diagnosis was 64 years. Overall incidence was 0.44 per million, and was higher among blacks (O.R.:1.10-2.07:1) and males (O.R.:1.38-2.06:1). Nasal cavity (41.5%) was the most common site, followed by maxillary (26.5%), and ethmoid (17.4%) sinuses. Intestinal-type adenocarcinoma was less likely than Adenocarcinoma not otherwise specified (ANOS) to be found in the maxillary sinus (8.8% vs. 30.6%, p < .05). Surgery alone (48.56%) was the most common treatment modality, followed by surgery and radiotherapy (RT) (32.5%), and RT alone (11.6%). DSS at 5, 10, and 20 years were 63.8%, 57.6%, and 47.0%, respectively. DSS was higher for nasal cavity SNAC, lower grade, lower stage, and those receiving surgery only. CONCLUSIONS: SNAC is more common among men and blacks. Incidence has not changed significantly in the past 40 years. Survival varies with grade, stage, histology, subsite, and treatment.
OBJECTIVE: To determine the incidence and survival of sinonasal adenocarcinoma (SNAC) by subsite and histologic subtype. STUDY DESIGN: Retrospective database review. METHODS: Using the SEER database, we performed a retrospective analysis, identified cases of SNAC diagnosed between 1973 and 2013 and analyzed demographic, histopathology, clinicopathology, and determinants of disease specific survival (DSS). RESULTS: A total of 746 patients with SNAC were identified. Median age at diagnosis was 64 years. Overall incidence was 0.44 per million, and was higher among blacks (O.R.:1.10-2.07:1) and males (O.R.:1.38-2.06:1). Nasal cavity (41.5%) was the most common site, followed by maxillary (26.5%), and ethmoid (17.4%) sinuses. Intestinal-type adenocarcinoma was less likely than Adenocarcinoma not otherwise specified (ANOS) to be found in the maxillary sinus (8.8% vs. 30.6%, p < .05). Surgery alone (48.56%) was the most common treatment modality, followed by surgery and radiotherapy (RT) (32.5%), and RT alone (11.6%). DSS at 5, 10, and 20 years were 63.8%, 57.6%, and 47.0%, respectively. DSS was higher for nasal cavity SNAC, lower grade, lower stage, and those receiving surgery only. CONCLUSIONS:SNAC is more common among men and blacks. Incidence has not changed significantly in the past 40 years. Survival varies with grade, stage, histology, subsite, and treatment.
Authors: Santiago Cabezas-Camarero; Virginia de la Orden García; Vanesa García-Barberán; Beatriz Mediero-Valeros; Ahmad Issa Subhi-Issa; Patricia Llovet García; Inmaculada Bando-Polaino; Salomé Merino Menéndez; Pedro Pérez-Segura; Eduardo Díaz-Rubio Journal: Oncologist Date: 2019-01-02
Authors: Paula Sánchez-Fernández; Cristina Riobello; María Costales; Blanca Vivanco; Virginia N Cabal; Rocío García-Marín; Laura Suárez-Fernández; Fernando López; Rubén Cabanillas; Mario A Hermsen; José Luis Llorente Journal: Sci Rep Date: 2021-01-26 Impact factor: 4.379