Evgeny V Khmelevsky1, Irina N Kancheli2, Vladimir S Khoroshkov2, Andrey D Kaprin1. 1. P.A. Herzen Moscow Scientific and Research Oncological Institute, Health Ministry of the Russian Federation, 2 Botkinsky Pr., 125284 Moscow, Russian Federation. 2. FSBI "SSC RF Institute for Theoretical and Experimental Physics" SRC "Kurchatov Institute", B. Cheremushkinskaya Str.25, 117218 Moscow, Russian Federation.
Abstract
AIM: This study evaluated the frequency and long-term dynamics of early and late post irradiation damage after proton-photon or photon therapy for locally advanced prostate cancer. BACKGROUND: The results of a randomized study of proton-photon or photon therapy using several fractionation regimes were analyzed in 272 patients with high and intermediate risk of progression. MATERIALS AND METHODS: Three variants of proton boost fractionation were studied sequentially: 3.0 (8 daily fractions), 4.0 (5 fractions, 3 or 5 fractions/week), and 5.5 (3 fractions, 3 fractions/week) Gy(RBE). RESULTS: A significant decrease in the severity of both acute and late gastrointestinal injuries is achievable with a proton beam. The dynamics of late gastrointestinal and genitourinary toxicity over a 10-year period were generally characterized by a decrease in severity of morbidity by 30% and 15%, respectively. CONCLUSIONS: Local irradiation with a fractional dose of 3.0-5.5 Gy(RBE) and a cumulative dose of 28.0-28.8 Gy(RBE) for protons significantly reduces the early and late rectitis severity, but does not reduce the risk of lower urinary tract injuries. Fractionation regimens do not significantly differ in toxicity levels.
AIM: This study evaluated the frequency and long-term dynamics of early and late post irradiation damage after proton-photon or photon therapy for locally advanced prostate cancer. BACKGROUND: The results of a randomized study of proton-photon or photon therapy using several fractionation regimes were analyzed in 272 patients with high and intermediate risk of progression. MATERIALS AND METHODS: Three variants of proton boost fractionation were studied sequentially: 3.0 (8 daily fractions), 4.0 (5 fractions, 3 or 5 fractions/week), and 5.5 (3 fractions, 3 fractions/week) Gy(RBE). RESULTS: A significant decrease in the severity of both acute and late gastrointestinal injuries is achievable with a proton beam. The dynamics of late gastrointestinal and genitourinary toxicity over a 10-year period were generally characterized by a decrease in severity of morbidity by 30% and 15%, respectively. CONCLUSIONS: Local irradiation with a fractional dose of 3.0-5.5 Gy(RBE) and a cumulative dose of 28.0-28.8 Gy(RBE) for protons significantly reduces the early and late rectitis severity, but does not reduce the risk of lower urinary tract injuries. Fractionation regimens do not significantly differ in toxicity levels.
Authors: Patrick A Kupelian; Vipul V Thakkar; Deepak Khuntia; Chandana A Reddy; Eric A Klein; Arul Mahadevan Journal: Int J Radiat Oncol Biol Phys Date: 2005-09-19 Impact factor: 7.038
Authors: Eric E Yeoh; Rochelle J Botten; Julie Butters; Addolorata C Di Matteo; Richard H Holloway; Jack Fowler Journal: Int J Radiat Oncol Biol Phys Date: 2010-10-08 Impact factor: 7.038
Authors: Berit L Madsen; R Alex Hsi; Huong T Pham; Jack F Fowler; Laura Esagui; John Corman Journal: Int J Radiat Oncol Biol Phys Date: 2007-03-15 Impact factor: 7.038
Authors: Raymond Miralbell; Stephen A Roberts; Eduardo Zubizarreta; Jolyon H Hendry Journal: Int J Radiat Oncol Biol Phys Date: 2011-02-15 Impact factor: 7.038
Authors: Anthony L Zietman; Kyounghwa Bae; Jerry D Slater; William U Shipley; Jason A Efstathiou; John J Coen; David A Bush; Margie Lunt; Daphna Y Spiegel; Rafi Skowronski; B Rodney Jabola; Carl J Rossi Journal: J Clin Oncol Date: 2010-02-01 Impact factor: 44.544
Authors: Lisa McGee; Nancy P Mendenhall; Randal H Henderson; Christopher G Morris; Romaine C Nichols; Robert J Marcus; Zuofeng Li; William M Mendenhall; Christopher R Williams; Bradford S Hoppe Journal: Acta Oncol Date: 2012-12-17 Impact factor: 4.089
Authors: Kiran Devisetty; Kevin C Zorn; Mark H Katz; Ashesh B Jani; Stanley L Liauw Journal: Int J Radiat Oncol Biol Phys Date: 2010-01-04 Impact factor: 7.038