Mónika Patricia Consuegra-Rodríguez1, Diana Meliza Hidalgo-Zambrano2, Heriberto Vásquez-Serna3, Carlos E Jimenez-Canizales4, Esteban Parra-Valencia5, Alfonso J Rodriguez-Morales6. 1. Faculty of Health Sciences, Universidad Autónoma de Bucaramanga, Bucaramanga, Santander, Colombia. 2. Ibagué Saludable Research Group, Secretary of Health, Ibagué, Tolima, Colombia; ESE Hospital Santa Bárbara de Venadillo, Venadillo, Tolima, Colombia; Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Colombia. 3. Ibagué Saludable Research Group, Secretary of Health, Ibagué, Tolima, Colombia. 4. Ibagué Saludable Research Group, Secretary of Health, Ibagué, Tolima, Colombia; ESE Hospital Santa Bárbara de Venadillo, Venadillo, Tolima, Colombia; Department of Internal Medicine, Faculty of Health Sciences, Universidad Surcolombiana, Neiva, Colombia; Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Colombia; Colombian Collaborative Network of Zika, Chikungunya and Other Arboviruses (RECOLZIKA), Pereira, Risaralda, Colombia. 5. Colombian Collaborative Network of Zika, Chikungunya and Other Arboviruses (RECOLZIKA), Pereira, Risaralda, Colombia; Facultad de Medicina, Universidad Católica de la Santísima Concepción, Concepción, Chile. 6. Public Health and Infection Research Group, Faculty of Health Sciences, Universidad Tecnológica de Pereira, Pereira, Colombia; Colombian Collaborative Network of Zika, Chikungunya and Other Arboviruses (RECOLZIKA), Pereira, Risaralda, Colombia; Committee on Zoonoses, Tropical Medicine and Travel Medicine, Asociación Colombiana de Infectología (ACIN), Bogota, Colombia; Working Group on Zoonoses, International Society for Chemotherapy, Aberdeen, UK; Research Group Medical and Diagnostic Images (GRIMEID), IPS Imágenes Diagnósticas S.A., Pereira, Risaralda, Colombia; Medical School, Faculty of Health Sciences, UniFranz, Cochabamba, Bolivia. Electronic address: arodriguezm@utp.edu.co.
Abstract
INTRODUCTION: Chronic Inflammatory Rheumatism (CIR) is one of the recognized and increasingly reported consequence post-chikungunya infection (pCHIK) in Colombia and Latin America. METHODS: Retrospective cohort study of 128 patients with CHIK that persisted with pCHIK-CIR after 59-68 weeks (1.13-1.31 years). This information was evaluated by means of a telephone survey and according to validated criteria (WHO 2015) previously (patients with >12 weeks post-CHIK with ≥1 manifestations [continuous/recurrent]: chronic polyarthralgia [pCHIK-CPA], stiffness and/or joint edema). RESULTS: Of the total CHIK-infected subjects finally included (n = 65), 28 (43.1%) reported pCHIK-CPA; and 38 patients (58.5%) at least one persistent rheumatological symptoms over the last year (pCHIK-CIR); 38.5% of them, morning stiffness, 18.5% joint edema, and 3.1% joint redness. No significant sex differences were found; 60% of patients with pCHIK-CPA aged> 40 years (RR = 3.75; 95%CI 1.47-9.53). The 29.2% of patients required medical attention because of symptoms. CONCLUSIONS: Nearly half of patients with CHIK had at least one rheumatologic symptom persistent over a year, and the third of them, pCHIK-CPA. These results are comparable with previous estimates obtained in other cohorts in the country (Risaralda and Sucre) and are consistent with results from other studies in France and India.
INTRODUCTION: Chronic Inflammatory Rheumatism (CIR) is one of the recognized and increasingly reported consequence post-chikungunya infection (pCHIK) in Colombia and Latin America. METHODS: Retrospective cohort study of 128 patients with CHIK that persisted with pCHIK-CIR after 59-68 weeks (1.13-1.31 years). This information was evaluated by means of a telephone survey and according to validated criteria (WHO 2015) previously (patients with >12 weeks post-CHIK with ≥1 manifestations [continuous/recurrent]: chronic polyarthralgia [pCHIK-CPA], stiffness and/or joint edema). RESULTS: Of the total CHIK-infected subjects finally included (n = 65), 28 (43.1%) reported pCHIK-CPA; and 38 patients (58.5%) at least one persistent rheumatological symptoms over the last year (pCHIK-CIR); 38.5% of them, morning stiffness, 18.5% joint edema, and 3.1% joint redness. No significant sex differences were found; 60% of patients with pCHIK-CPA aged> 40 years (RR = 3.75; 95%CI 1.47-9.53). The 29.2% of patients required medical attention because of symptoms. CONCLUSIONS: Nearly half of patients with CHIK had at least one rheumatologic symptom persistent over a year, and the third of them, pCHIK-CPA. These results are comparable with previous estimates obtained in other cohorts in the country (Risaralda and Sucre) and are consistent with results from other studies in France and India.
Authors: Marta Díaz-Menéndez; Elena Trigo Esteban; Mugen Ujiie; Guido Calleri; Camilla Rothe; Denis Malvy; Emanuele Nicastri; Alfred L Bissinger; Marc Grandadam; Jonathan D Alpern; Federico Gobbi; Patricia Schlagenhauf; Alexandre Duvignaud; Emilie Javelle; Takato Nakamoto; Spinello Antinori; Davidson H Hamer Journal: Euro Surveill Date: 2020-01
Authors: Gergana Zahmanova; Katerina Takova; Rumyana Valkova; Valentina Toneva; Ivan Minkov; Anton Andonov; Georgi L Lukov Journal: Life (Basel) Date: 2022-01-21