| Literature DB >> 29201156 |
Abstract
Raynaud's phenomenon (RP) is relevant to the rheumatologist because it may signify an underlying connective tissue disease and also because it can be very challenging to treat, especially when it has progressed to digital ulceration or critical ischaemia. This review article discusses diagnosis (does this patient have an underlying connective tissue disease?), including the role for nailfold capillaroscopy, and treatment. Management of 'uncomplicated' RP is first described and then treatment of RP complicated by progression to digital ulceration or critical ischaemia, highlighting recent advances (including phosphodiesterase type 5 inhibition, and endothelin 1 receptor antagonism) and the evidence base underpinning these. Possible future therapies are briefly discussed.Entities:
Keywords: Raynaud’s phenomenon; critical ischaemia; digital ulceration; systemic sclerosis; treatment
Year: 2017 PMID: 29201156 PMCID: PMC5700788 DOI: 10.1177/1759720X17740074
Source DB: PubMed Journal: Ther Adv Musculoskelet Dis ISSN: 1759-720X Impact factor: 5.346