| Literature DB >> 29200661 |
Jeroen Leijten1,2,3, Jungmok Seo1,2,4, Kan Yue1,2, Grissel Trujillo-de Santiago1,2,5,6, Ali Tamayol1,2, Guillermo U Ruiz-Esparza1,2, Su Ryon Shin1,2, Roholah Sharifi1,2, Iman Noshadi1,2, Mario Moisés Álvarez1,2,5,6, Yu Shrike Zhang1,2, Ali Khademhosseini1,2,7,8.
Abstract
Recent years have seen tremendous advances in the field of hydrogel-based biomaterials. One of the most prominent revolutions in this field has been the integration of elements or techniques that enable spatial and temporal control over hydrogels' properties and functions. Here, we critically review the emerging progress of spatiotemporal control over biomaterial properties towards the development of functional engineered tissue constructs. Specifically, we will highlight the main advances in the spatial control of biomaterials, such as surface modification, microfabrication, photo-patterning, and three-dimensional (3D) bioprinting, as well as advances in the temporal control of biomaterials, such as controlled release of molecules, photocleaving of proteins, and controlled hydrogel degradation. We believe that the development and integration of these techniques will drive the engineering of next-generation engineered tissues.Entities:
Keywords: Biomaterials; Bioprinting; Cell-biomaterial interaction; Cellular microenvironments; Hydrogel; Microfabrication; Tissue engineering
Year: 2017 PMID： 29200661 PMCID： PMC5708586 DOI： 10.1016/j.mser.2017.07.001
Source DB: PubMed Journal: Mater Sci Eng R Rep ISSN： 0927-796X Impact factor: 36.214