Literature DB >> 29200007

Disruption of the gut-liver axis in the pathogenesis of acute-on-chronic liver failure.

Tao Zhang1,2, Kewei Sun1, Ya Wang1, Lei Huang3, Ren Lang4, Wei Jiang2,5.   

Abstract

Acute-on-chronic liver failure (ACLF) is characterized by organ failure mediated by acute decompensation of cirrhosis. Recent studies have highlighted the importance of the gut-liver axis (GLS) and its association with ACLF pathogenesis. In this review, we discuss the mechanisms related to the alteration of the GLA and their involvement in ACLF pathogenesis and suggest some possible therapeutic options that could modulate the GLA dysfunction. This knowledge may provide information useful for the design of therapeutic strategies for gut dysbiosis and its complications in ACLF.

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Year:  2018        PMID： 29200007      PMCID： PMC5738259          DOI： 10.1097/MEG.0000000000001026

Source DB:  PubMed          Journal:  Eur J Gastroenterol Hepatol        ISSN： 0954-691X            Impact factor:   2.586


  70 in total

Review 1.  The mucosal immune system of the respiratory tract.

Authors:  Shintaro Sato; Hiroshi Kiyono
Journal:  Curr Opin Virol       Date:  2012-04-25       Impact factor: 7.090

2.  The role of lipopolysaccharide/toll-like receptor 4 signaling in chronic liver diseases.

Authors:  João-Bruno Soares; Pedro Pimentel-Nunes; Roberto Roncon-Albuquerque; Adelino Leite-Moreira
Journal:  Hepatol Int       Date:  2010-10-21       Impact factor: 6.047

Review 3.  Gut-liver axis in liver cirrhosis: How to manage leaky gut and endotoxemia.

Authors:  Hiroshi Fukui
Journal:  World J Hepatol       Date:  2015-03-27

4.  Correlation between high mobility group box-1 protein and chronic hepatitis B infection with severe hepatitis B and acute-on-chronic liver failure: a meta-analysis.

Authors:  Yi-Bing Hu; Dan-Ping Hu; Rong-Quan Fu
Journal:  Minerva Med       Date:  2016-12-14       Impact factor: 4.806

Review 5.  Gut-liver axis.

Authors:  S Zeuzem
Journal:  Int J Colorectal Dis       Date:  2000-04       Impact factor: 2.571

6.  Increased MerTK expression in circulating innate immune cells of patients with septic shock.

Authors:  Caroline Guignant; Fabienne Venet; Séverine Planel; Julie Demaret; Aurélie Gouel-Chéron; Christophe Nougier; Arnaud Friggeri; Bernard Allaouchiche; Alain Lepape; Guillaume Monneret
Journal:  Intensive Care Med       Date:  2013-07-09       Impact factor: 17.440

7.  Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis.

Authors:  Richard Moreau; Rajiv Jalan; Pere Gines; Marco Pavesi; Paolo Angeli; Juan Cordoba; Francois Durand; Thierry Gustot; Faouzi Saliba; Marco Domenicali; Alexander Gerbes; Julia Wendon; Carlo Alessandria; Wim Laleman; Stefan Zeuzem; Jonel Trebicka; Mauro Bernardi; Vicente Arroyo
Journal:  Gastroenterology       Date:  2013-03-06       Impact factor: 22.682

Review 8.  Immune dysfunction in cirrhosis.

Authors:  Nora Sipeki; Peter Antal-Szalmas; Peter L Lakatos; Maria Papp
Journal:  World J Gastroenterol       Date:  2014-03-14       Impact factor: 5.742

9.  Allicin ameliorates intraintestinal bacterial translocation after trauma/hemorrhagic shock in rats: The role of mesenteric lymph node dendritic cell.

Authors:  Yun Zhang; Jian Zhang; Tao Xu; Wei Wu; Fang-Fang Huang; Wen-Qiao Yu; Shao-Yang Zhang; Ting-Bo Liang
Journal:  Surgery       Date:  2016-10-04       Impact factor: 3.982

Review 10.  The role of probiotics and prebiotics in inducing gut immunity.

Authors:  Angélica T Vieira; Mauro M Teixeira; Flaviano S Martins
Journal:  Front Immunol       Date:  2013-12-12       Impact factor: 7.561
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  5 in total

1.  Bone marrow mesenchymal stem cells differentiate into intestinal epithelioid cells through the ERK1/2 pathway.

Authors:  Ting Jiang; Meng-Lin Shi; Geng Xia; Yi-Na Yang; Jia-Min Xu; Yun-Jie Lei; Ying-Mei Tang; Jin-Hui Yang
Journal:  Turk J Gastroenterol       Date:  2020-06       Impact factor: 1.852

2.  Increased Endotoxin Activity Is Associated with the Risk of Developing Acute-on-Chronic Liver Failure.

Authors:  Hiroaki Takaya; Tadashi Namisaki; Shinya Sato; Kosuke Kaji; Yuki Tsuji; Daisuke Kaya; Yukihisa Fujinaga; Yasuhiko Sawada; Naotaka Shimozato; Hideto Kawaratani; Kei Moriya; Takemi Akahane; Akira Mitoro; Hitoshi Yoshiji
Journal:  J Clin Med       Date:  2020-05-14       Impact factor: 4.241

3.  Acute-on-Chronic Liver Failure: From Basic Research to Clinical Applications.

Authors:  En-Qiang Chen; Tetsuro Shimakami; Yu-Chen Fan; Paolo Angeli
Journal:  Can J Gastroenterol Hepatol       Date:  2018-10-08

4.  ADAMTS13, VWF, and Endotoxin Are Interrelated and Associated with the Severity of Liver Cirrhosis via Hypercoagulability.

Authors:  Hiroaki Takaya; Tadashi Namisaki; Shohei Asada; Satoshi Iwai; Takahiro Kubo; Junya Suzuki; Masahide Enomoto; Yuki Tsuji; Yukihisa Fujinaga; Norihisa Nishimura; Yasuhiko Sawada; Kosuke Kaji; Hideto Kawaratani; Kei Moriya; Takemi Akahane; Masanori Matsumoto; Hitoshi Yoshiji
Journal:  J Clin Med       Date:  2022-03-26       Impact factor: 4.241

5.  Patterns of acute decompensation in hospitalized patients with cirrhosis and course of acute-on-chronic liver failure.

Authors:  Lorenz Balcar; Georg Semmler; Katharina Pomej; Benedikt Simbrunner; David Bauer; Lukas Hartl; Mathias Jachs; Rafael Paternostro; Theresa Bucsics; Matthias Pinter; Michael Trauner; Mattias Mandorfer; Thomas Reiberger; Bernhard Scheiner
Journal:  United European Gastroenterol J       Date:  2021-05       Impact factor: 4.623
  5 in total

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