Literature DB >> 291996

Regulation of the state of phosphorylation of specific neuronal proteins in mouse brain by in vivo administration of anesthetic and convulsant agents.

U Strömbom, J Forn, A C Dolphin, P Greengard.   

Abstract

The effect of drug treatment in vivo on the state of phosphorylation of two specific neuronal proteins, proteins Ia and Ib, has been studied in mouse brain. For this purpose, animals were killed by immersion into liquid nitrogen, and proteins Ia and Ib were extracted by a procedure designed to prevent alterations in their state of phosphorylation. Several anesthetic agents (pentobarbital, chloral hydrate, and urethane) each caused a decrease in the state of phosphorylation of these proteins. Conversely, the convulsant agents pentylenetetrazol and picrotoxin each caused an increase in the state of phosphorylation of these proteins. Neither the anesthetic nor the convulsant agents affected the total amount of these proteins. The results are compatible with a role for proteins Ia and Ib in neuronal function.

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Year:  1979        PMID： 291996      PMCID： PMC411646          DOI： 10.1073/pnas.76.9.4687

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  14 in total

1.  Phosphorylation-dephosphorylation of the 18,000-dalton light chain of myosin during the contraction-relaxation cycle of frog muscle.

Authors:  K Bárány; M Bárány; J M Gillis; M J Kushmerick
Journal:  J Biol Chem       Date:  1979-05-10       Impact factor: 5.157

2.  Neuronal localization of specific brain phosphoproteins.

Authors:  W Sieghart; J Forn; R Schwarcz; J T Coyle; P Greengard
Journal:  Brain Res       Date:  1978-11-10       Impact factor: 3.252

3.  Voltage-sensitive calcium channels regulate guanosine 3',5'-cyclic monophosphate levels in neuroblastoma cells.

Authors:  R E Study; X O Breakefield; T Bartfai; P Greengard
Journal:  Proc Natl Acad Sci U S A       Date:  1978-12       Impact factor: 11.205

4.  Cyclic AMP-stimulated protein kinases at brain synaptic junctions.

Authors:  P T Kelly; C W Cotman; M Largen
Journal:  J Biol Chem       Date:  1979-03-10       Impact factor: 5.157

5.  Molecular forms and subunit composition of a cyclic adenosine 3',5'-monophosphate-dependent protein kinase purified from bovine heart muscle.

Authors:  C S Rubin; J Erlichman; O M Rosen
Journal:  J Biol Chem       Date:  1972-01-10       Impact factor: 5.157

6.  Preparation of homogeneous cyclic AMP-dependent protein kinase(s) and its subunits from rabbit skeletal muscle.

Authors:  J A Beavo; P J Bechtel; E G Krebs
Journal:  Methods Enzymol       Date:  1974       Impact factor: 1.600

7.  Depolarizing agents and cyclic nucleotides regulate the phosphorylation of specific neuronal proteins in rat cerebral cortex slices.

Authors:  J Forn; P Greengard
Journal:  Proc Natl Acad Sci U S A       Date:  1978-10       Impact factor: 11.205

8.  Depolarization-induced phosphorylation of specific proteins, mediated by calcium ion influx, in rat brain synaptosomes.

Authors:  B K Krueger; J Forn; P Greengard
Journal:  J Biol Chem       Date:  1977-04-25       Impact factor: 5.157

9.  Purification of phosphoprotein phosphatase from bovine cardiac muscle that catalyzes dephosphorylation of cyclic AMP-binding protein component of protein kinase.

Authors:  C K Chou; J Alfano; O M Rosen
Journal:  J Biol Chem       Date:  1977-05-10       Impact factor: 5.157

10.  Adenosine 3':5'-monophosphate-regulated phosphoprotein system of neuronal membranes. I. Solubilization, purification, and some properties of an endogenous phosphoprotein.

Authors:  T Ueda; P Greengard
Journal:  J Biol Chem       Date:  1977-07-25       Impact factor: 5.157
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  6 in total

1.  Early Exposure to General Anesthesia Disrupts Spatial Organization of Presynaptic Vesicles in Nerve Terminals of the Developing Rat Subiculum.

Authors:  N Lunardi; A Oklopcic; M Prillaman; A Erisir; V Jevtovic-Todorovic
Journal:  Mol Neurobiol       Date:  2015-06-06       Impact factor: 5.590

Review 2.  Neuronal phosphoproteins. Mediators of signal transduction.

Authors:  P Greengard
Journal:  Mol Neurobiol       Date:  1987 Spring-Summer       Impact factor: 5.590

3.  Multiple phosphorylation sites in protein I and their differential regulation by cyclic AMP and calcium.

Authors:  W B Huttner; P Greengard
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

4.  Immunocytochemical localization, in synapses, of protein I, an endogenous substrate for protein kinases in mammalian brain.

Authors:  F E Bloom; T Ueda; E Battenberg; P Greengard
Journal:  Proc Natl Acad Sci U S A       Date:  1979-11       Impact factor: 11.205

5.  Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation.

Authors:  W B Huttner; W Schiebler; P Greengard; P De Camilli
Journal:  J Cell Biol       Date:  1983-05       Impact factor: 10.539

6.  Isoaspartate accumulation in mouse brain is associated with altered patterns of protein phosphorylation and acetylation, some of which are highly sex-dependent.

Authors:  Zhenxia Qin; Rachel S Kaufman; Rana N Khoury; Mitri K Khoury; Dana W Aswad
Journal:  PLoS One       Date:  2013-11-05       Impact factor: 3.240
  6 in total

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