Alex S Willoughby1, Vivian S Vuong1, David Cunefare2, Sina Farsiu2, Glenn Noronha3, Ronald P Danis4, Glenn Yiu5. 1. Department of Ophthalmology and Vision Science, University of California, Davis, Sacramento, California. 2. Department of Biomedical Engineering, Duke University, Durham, North Carolina. 3. Clearside Biomedical, Inc, Alpharetta, Georgia. 4. Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin. 5. Department of Ophthalmology and Vision Science, University of California, Davis, Sacramento, California. Electronic address: gyiu@ucdavis.edu.
Abstract
PURPOSE: To evaluate choroidal and suprachoroidal changes following suprachoroidal injection of triamcinolone acetonide injectable suspension (CLS-TA), in eyes with macular edema due to retinal vein occlusion (RVO). DESIGN: Prospective cohort study within a randomized, controlled phase 2 clinical trial. METHODS:Enhanced depth imaging optical coherence tomography (EDI-OCT) images were analyzed from 38 eyes of 38 treatment-naïve patients with macular edema due to RVO, enrolled in the prospective Suprachoroidal Injection of Triamcinolone Acetonide with Intravitreal Aflibercept in Subjects with Macular Edema Due to Retinal Vein Occlusion (TANZANITE) study who received either asuprachoroidal injection of CLS-TA with an intravitreal injection of aflibercept (combination arm) or only an intravitreal injection of aflibercept (monotherapy arm), followed by monthly intravitreal aflibercept injections in both arms based on pro re nata criteria. RESULTS:Macular choroidal thickness measured to the outer choroidal vessel lumen (vascular choroidal thickness, VCT), outer choroid stroma (stromal choroidal thickness, SCT), or inner scleral border (total choroidal thickness, TCT) showed no significant changes over 3 months in both study arms (P = .231-.342). Eyes that received combination therapy showed a trend toward thickening of the suprachoroidal space (SCS) compared with monotherapy alone (13.4 μm vs 5.3 μm at 3 months; P = .077). In the 15 eyes that demonstrated a visible SCS at baseline, the SCS expanded significantly after suprachoroidal CLS-TA injection (16.2 μm to 27.8 μm at 3 months; P = .033). CONCLUSIONS: Suprachoroidal injection of CLS-TA does not alter choroidal thickness in eyes with macular edema due to RVO, but may result in expansion of the SCS.
RCT Entities:
PURPOSE: To evaluate choroidal and suprachoroidal changes following suprachoroidal injection of triamcinolone acetonide injectable suspension (CLS-TA), in eyes with macular edema due to retinal vein occlusion (RVO). DESIGN: Prospective cohort study within a randomized, controlled phase 2 clinical trial. METHODS: Enhanced depth imaging optical coherence tomography (EDI-OCT) images were analyzed from 38 eyes of 38 treatment-naïve patients with macular edema due to RVO, enrolled in the prospective Suprachoroidal Injection of Triamcinolone Acetonide with Intravitreal Aflibercept in Subjects with Macular Edema Due to Retinal Vein Occlusion (TANZANITE) study who received either a suprachoroidal injection of CLS-TA with an intravitreal injection of aflibercept (combination arm) or only an intravitreal injection of aflibercept (monotherapy arm), followed by monthly intravitreal aflibercept injections in both arms based on pro re nata criteria. RESULTS: Macular choroidal thickness measured to the outer choroidal vessel lumen (vascular choroidal thickness, VCT), outer choroid stroma (stromal choroidal thickness, SCT), or inner scleral border (total choroidal thickness, TCT) showed no significant changes over 3 months in both study arms (P = .231-.342). Eyes that received combination therapy showed a trend toward thickening of the suprachoroidal space (SCS) compared with monotherapy alone (13.4 μm vs 5.3 μm at 3 months; P = .077). In the 15 eyes that demonstrated a visible SCS at baseline, the SCS expanded significantly after suprachoroidal CLS-TA injection (16.2 μm to 27.8 μm at 3 months; P = .033). CONCLUSIONS: Suprachoroidal injection of CLS-TA does not alter choroidal thickness in eyes with macular edema due to RVO, but may result in expansion of the SCS.
Authors: Osman Cekiç; Stanley Chang; Joseph J Tseng; Gaetano R Barile; Lucian V Del Priore; Harold Weissman; William M Schiff; Michael D Ober Journal: Retina Date: 2005 Oct-Nov Impact factor: 4.256
Authors: Julia A Haller; Francesco Bandello; Rubens Belfort; Mark S Blumenkranz; Mark Gillies; Jeffrey Heier; Anat Loewenstein; Young Hee Yoon; Jenny Jiao; Xiao-Yan Li; Scott M Whitcup; Joanne Li Journal: Ophthalmology Date: 2011-07-20 Impact factor: 12.079
Authors: Stephanie J Chiu; Xiao T Li; Peter Nicholas; Cynthia A Toth; Joseph A Izatt; Sina Farsiu Journal: Opt Express Date: 2010-08-30 Impact factor: 3.894
Authors: Eric J Kim; Weijie V Lin; Sean M Rodriguez; Ariel Chen; Asad Loya; Christina Y Weng Journal: Curr Diab Rep Date: 2019-07-29 Impact factor: 4.810
Authors: Glenn Yiu; Zhe Wang; Christian Munevar; Eric Tieu; Bradley Shibata; Brittany Wong; David Cunefare; Sina Farsiu; Jeffrey Roberts; Sara M Thomasy Journal: Exp Eye Res Date: 2018-01-17 Impact factor: 3.467
Authors: Arshad M Khanani; Mathew J Thomas; Aamir A Aziz; Christina Y Weng; Carl J Danzig; Glenn Yiu; Szilárd Kiss; Nadia K Waheed; Peter K Kaiser Journal: Eye (Lond) Date: 2022-01-11 Impact factor: 4.456
Authors: Yu Zhang; Hojjat Bazzazi; Raquel Lima E Silva; Niranjan B Pandey; Jordan J Green; Peter A Campochiaro; Aleksander S Popel Journal: Invest Ophthalmol Vis Sci Date: 2018-10-01 Impact factor: 4.799