| Literature DB >> 29198893 |
Mitsuru Tsuji1, Nongluk Sriwilaijaroen2, Hideo Inoue3, Kazuhiko Miki1, Kaoru Kinoshita1, Kiyotaka Koyama1, Kimio Furuhata4, Yasuo Suzuki5, Kunio Takahashi6.
Abstract
We are interested in new non-natural glycosides with sialic acid conjugates and their biological activities. We report the synthesis of eleven non-natural occurring glycosides, which are triterpene (glycyrrhetinic acid and its derivatives)-sialic acid conjugates, and their inhibitory activities against influenza virus sialidases and influenza virus multiplication in MDCK host cells. Deoxoglycyrrhetol-sialic acid conjugates (6d and 6e) and oleanolic acid-sialic acid conjugates (7d and 7e) showed strong inhibitory activities against three subtypes of influenza virus sialidases. These four compounds (6d, 6e, 7d and 7e) showed clear inhibition to influenza virus multiplication but not to MDCK host cell survival.Entities:
Keywords: Anti-influenza virus; Glycyrrhetinic acid; Sialic acid; Sialidase; Triterpene
Mesh：
Substances：
Year: 2017 PMID： 29198893 DOI： 10.1016/j.bmc.2017.09.038
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641