Literature DB >> 29198439

Mitochondrial Transfer in the Leukemia Microenvironment.

Emmanuel Griessinger1, Ruxanda Moschoi2, Giulia Biondani2, Jean-François Peyron3.   

Abstract

The bone marrow microenvironment (BMME) is a complex ecosystem that instructs and protects hematopoietic stem cells (HSCs) and their malignant counterparts, the leukemia-initiating cells (LICs). Within the physical and functional crosstalk that takes place between HSCs, LICs, and the BMME, the transfer of organelles and of mitochondria in particular is an important new intercellular communication mode in addition to adhesion molecules, tunneling nanotubes (TNTs), and the paracrine secretion of cytokines, (onco)metabolites, and extracellular vesicles (EVs). In this review we discuss the functional roles of mitochondrial transfer between BMME and leukemic cells, and give insights into this new mechanism of drug resistance whose understanding will open the way to innovative anticancer adjuvant treatments.
Copyright © 2017 Elsevier Inc. All rights reserved.

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Year:  2017        PMID： 29198439     DOI： 10.1016/j.trecan.2017.10.003

Source DB:  PubMed          Journal:  Trends Cancer        ISSN： 2405-8025


  31 in total

1.  Bone marrow regeneration requires mitochondrial transfer from donor Cx43-expressing hematopoietic progenitors to stroma.

Authors:  Karin Golan; Abhishek K Singh; Orit Kollet; Mayla Bertagna; Mark J Althoff; Eman Khatib-Massalha; Ekaterina Petrovich-Kopitman; Ashley M Wellendorf; Hassan Massalha; Smadar Levin-Zaidman; Tali Dadosh; Breanna Bohan; Mruniya V Gawali; Biplab Dasgupta; Tsvee Lapidot; Jose A Cancelas
Journal:  Blood       Date:  2020-12-03       Impact factor: 22.113

2.  Dietary lipids inhibit mitochondria transfer to macrophages to divert adipocyte-derived mitochondria into the blood.

Authors:  Nicholas Borcherding; Wentong Jia; Rocky Giwa; Rachael L Field; John R Moley; Benjamin J Kopecky; Mandy M Chan; Bin Q Yang; Jessica M Sabio; Emma C Walker; Omar Osorio; Andrea L Bredemeyer; Terri Pietka; Jennifer Alexander-Brett; Sharon Celeste Morley; Maxim N Artyomov; Nada A Abumrad; Joel Schilling; Kory Lavine; Clair Crewe; Jonathan R Brestoff
Journal:  Cell Metab       Date:  2022-09-06       Impact factor: 31.373

3.  Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics.

Authors:  Leif S Ludwig; Caleb A Lareau; Jacob C Ulirsch; Elena Christian; Christoph Muus; Lauren H Li; Karin Pelka; Will Ge; Yaara Oren; Alison Brack; Travis Law; Christopher Rodman; Jonathan H Chen; Genevieve M Boland; Nir Hacohen; Orit Rozenblatt-Rosen; Martin J Aryee; Jason D Buenrostro; Aviv Regev; Vijay G Sankaran
Journal:  Cell       Date:  2019-02-28       Impact factor: 41.582

4.  Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity.

Authors:  Jonathan R Brestoff; Craig B Wilen; John R Moley; Yongjia Li; Wei Zou; Nicole P Malvin; Marina N Rowen; Brian T Saunders; Hongming Ma; Madison R Mack; Barry L Hykes; Dale R Balce; Anthony Orvedahl; Jesse W Williams; Nidhi Rohatgi; Xiaoyan Wang; Michael R McAllaster; Scott A Handley; Brian S Kim; John G Doench; Bernd H Zinselmeyer; Michael S Diamond; Herbert W Virgin; Andrew E Gelman; Steven L Teitelbaum
Journal:  Cell Metab       Date:  2020-12-04       Impact factor: 27.287

Review 5.  Role of Tunneling Nanotubes in Viral Infection, Neurodegenerative Disease, and Cancer.

Authors:  Vaibhav Tiwari; Raghuram Koganti; Greer Russell; Ananya Sharma; Deepak Shukla
Journal:  Front Immunol       Date:  2021-06-14       Impact factor: 7.561

Review 6.  Extracellular Vesicles: A New Prospective in Crosstalk between Microenvironment and Stem Cells in Hematological Malignancies.

Authors:  Ilaria Laurenzana; Daniela Lamorte; Stefania Trino; Luciana De Luca; Concetta Ambrosino; Pietro Zoppoli; Vitalba Ruggieri; Luigi Del Vecchio; Pellegrino Musto; Antonella Caivano; Geppino Falco
Journal:  Stem Cells Int       Date:  2018-05-27       Impact factor: 5.443

Review 7.  Generation and Release of Mitochondrial-Derived Vesicles in Health, Aging and Disease.

Authors:  Anna Picca; Flora Guerra; Riccardo Calvani; Hélio José Coelho-Junior; Maurizio Bossola; Francesco Landi; Roberto Bernabei; Cecilia Bucci; Emanuele Marzetti
Journal:  J Clin Med       Date:  2020-05-12       Impact factor: 4.241

Review 8.  The Functions, Methods, and Mobility of Mitochondrial Transfer Between Cells.

Authors:  Yiming Qin; Xin Jiang; Qi Yang; Jiaqi Zhao; Qiong Zhou; Yanhong Zhou
Journal:  Front Oncol       Date:  2021-05-10       Impact factor: 6.244

Review 9.  Therapeutic Targeting of the Leukaemia Microenvironment.

Authors:  Vincent Kuek; Anastasia M Hughes; Rishi S Kotecha; Laurence C Cheung
Journal:  Int J Mol Sci       Date:  2021-06-26       Impact factor: 5.923

10.  Tumor microtubes connect pancreatic cancer cells in an Arp2/3 complex-dependent manner.

Authors:  Casey J Latario; Lori W Schoenfeld; Charles L Howarth; Laura E Pickrell; Fatema Begum; Dawn A Fischer; Olivera Grbovic-Huezo; Steven D Leach; Yolanda Sanchez; Kerrington D Smith; Henry N Higgs
Journal:  Mol Biol Cell       Date:  2020-04-08       Impact factor: 4.138
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