Angela Ju1, Mark L Unruh2, Sara N Davison3, Juan Dapueto4, Mary Amanda Dew5, Richard Fluck6, Michael Germain7, Sarbjit Vanita Jassal8, Gregorio Obrador9, Donal O'Donoghue10, Peter Tugwell11, Jonathan C Craig12, Angelique F Ralph12, Martin Howell12, Allison Tong12. 1. Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia; Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, NSW, Australia. Electronic address: angela.ju@sydney.edu.au. 2. Division of Nephrology, University of New Mexico School of Medicine, Albuquerque, NM. 3. Division of Nephrology and Immunology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. 4. Departamento de Psicología Médica, Hospital de Clínicas, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay. 5. Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA. 6. Department of Renal Medicine, Royal Derby Hospital, Derby, United Kingdom. 7. Renal and Transplant Associates of New England, Division of Nephrology, Baystate Medical Center, Tufts University School of Medicine, Boston, MA. 8. Division of Nephrology, Department of Medicine, University Health Network, University of Toronto, Toronto, Ontario, Canada. 9. Universidad Panamericana School of Medicine, Mexico City, Mexico. 10. Department of Renal Medicine, Salford Royal Hospital, Salford, United Kingdom. 11. Department of Medicine, University of Ottawa, Ottawa, Canada. 12. Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia; Centre for Kidney Research, The Children's Hospital at Westmead, Sydney, NSW, Australia.
Abstract
BACKGROUND: Fatigue is a prevalent and debilitating symptom in patients receiving hemodialysis. We aimed to identify and evaluate the characteristics and psychometric properties of patient-reported outcome measures for fatigue in patients receiving hemodialysis, to inform the selection of a robust and feasible measure for use in randomized trials in hemodialysis. STUDY DESIGN: Systematic review of outcome measures for fatigue. SETTING & POPULATION: Patients receiving hemodialysis. SEARCH STRATEGY & SOURCES: MEDLINE, Embase, PsycINFO, and CINAHL from inception to April 2017 were searched for all studies that reported fatigue in patients receiving hemodialysis. ANALYTICAL APPROACH: With a focus on addressing methods, items (individual questions) from all measures were categorized into content and measurement dimensions of fatigue. We assessed the general characteristics (eg, number of items and cost) and psychometric properties of all measures. RESULTS: From 123 studies, we identified 43 different measures: 24 (55%) were developed specifically for the hemodialysis population (of which 18 were nonvalidated author-developed measures for use in their study only), 17 (40%) for other populations, and 2 (5%) for chronic kidney disease (all stages). The measures assessed 11 content dimensions of fatigue, the 3 most frequent being level of energy (19 [44%]), tiredness (15 [35%]), and life participation (14 [33%]); and 4 measurement dimensions: severity (34 [79%]), frequency (10 [23%]), duration (4 [9%]), and change (1 [2%]). The vitality subscale of the 36-Item Short Form Health Survey (SF-36) was the most frequently used (19 [15%] studies), but has only been tested for reliability in hemodialysis. Of the fatigue-specific measures, the Chalder Fatigue Scale was the only one evaluated in hemodialysis, but the full psychometric robustness remains uncertain. LIMITATIONS: For feasibility, we searched for validation studies in the hemodialysis population using the names of measures identified in the primary search strategy. CONCLUSIONS: A very wide range of measures have been used to assess fatigue in patients receiving hemodialysis, each varying in content and length. Many have limited validation data available in this population. A standardized and psychometrically robust measure that captures dimensions of fatigue that are important to patients is needed to estimate and improve this disabling complication of hemodialysis.
BACKGROUND:Fatigue is a prevalent and debilitating symptom in patients receiving hemodialysis. We aimed to identify and evaluate the characteristics and psychometric properties of patient-reported outcome measures for fatigue in patients receiving hemodialysis, to inform the selection of a robust and feasible measure for use in randomized trials in hemodialysis. STUDY DESIGN: Systematic review of outcome measures for fatigue. SETTING & POPULATION: Patients receiving hemodialysis. SEARCH STRATEGY & SOURCES: MEDLINE, Embase, PsycINFO, and CINAHL from inception to April 2017 were searched for all studies that reported fatigue in patients receiving hemodialysis. ANALYTICAL APPROACH: With a focus on addressing methods, items (individual questions) from all measures were categorized into content and measurement dimensions of fatigue. We assessed the general characteristics (eg, number of items and cost) and psychometric properties of all measures. RESULTS: From 123 studies, we identified 43 different measures: 24 (55%) were developed specifically for the hemodialysis population (of which 18 were nonvalidated author-developed measures for use in their study only), 17 (40%) for other populations, and 2 (5%) for chronic kidney disease (all stages). The measures assessed 11 content dimensions of fatigue, the 3 most frequent being level of energy (19 [44%]), tiredness (15 [35%]), and life participation (14 [33%]); and 4 measurement dimensions: severity (34 [79%]), frequency (10 [23%]), duration (4 [9%]), and change (1 [2%]). The vitality subscale of the 36-Item Short Form Health Survey (SF-36) was the most frequently used (19 [15%] studies), but has only been tested for reliability in hemodialysis. Of the fatigue-specific measures, the Chalder Fatigue Scale was the only one evaluated in hemodialysis, but the full psychometric robustness remains uncertain. LIMITATIONS: For feasibility, we searched for validation studies in the hemodialysis population using the names of measures identified in the primary search strategy. CONCLUSIONS: A very wide range of measures have been used to assess fatigue in patients receiving hemodialysis, each varying in content and length. Many have limited validation data available in this population. A standardized and psychometrically robust measure that captures dimensions of fatigue that are important to patients is needed to estimate and improve this disabling complication of hemodialysis.
Authors: Jennifer E Flythe; Adeline Dorough; Julia H Narendra; Rebecca L Wingard; Lorien S Dalrymple; Darren A DeWalt Journal: Qual Life Res Date: 2018-09-18 Impact factor: 4.147
Authors: Karine E Manera; Allison Tong; Jonathan C Craig; Jenny Shen; Shilpa Jesudason; Yeoungjee Cho; Benedicte Sautenet; Armando Teixeira-Pinto; Martin Howell; Angela Yee-Moon Wang; Edwina A Brown; Gillian Brunier; Jeffrey Perl; Jie Dong; Martin Wilkie; Rajnish Mehrotra; Roberto Pecoits-Filho; Saraladevi Naicker; Tony Dunning; Nicole Scholes-Robertson; David W Johnson Journal: Kidney Int Date: 2019-03-29 Impact factor: 10.612
Authors: Jennifer E Flythe; Tandrea S Hilliard; Kourtney Ikeler; San Keller; Debbie S Gipson; Amanda C Grandinetti; Robert J Nordyke; Ronald D Perrone; Prabir Roy-Chaudhury; Mark Unruh; Melissa West; Fraser Bocell; Frank P Hurst Journal: Clin J Am Soc Nephrol Date: 2020-04-10 Impact factor: 8.237
Authors: Angela Ju; Armando Teixeira-Pinto; Allison Tong; Alice C Smith; Mark Unruh; Sara N Davison; Juan Dapueto; Mary Amanda Dew; Richard Fluck; Michael J Germain; Sarbjit V Jassal; Gregorio T Obrador; Donal O'Donoghue; Andrea K Viecelli; Giovanni Strippoli; Marinella Ruospo; Delia Timofte; Ankit Sharma; Eric Au; Martin Howell; Daniel S J Costa; Samaya Anumudu; Jonathan C Craig; Claudia Rutherford Journal: Clin J Am Soc Nephrol Date: 2020-10-22 Impact factor: 8.237
Authors: Allison Tong; Braden Manns; Angela Yee Moon Wang; Brenda Hemmelgarn; David C Wheeler; John Gill; Peter Tugwell; Robert Pecoits-Filho; Sally Crowe; Tess Harris; Wim Van Biesen; Wolfgang C Winkelmayer; Adeera Levin; Aliza Thompson; Vlado Perkovic; Angela Ju; Talia Gutman; Amelie Bernier-Jean; Andrea K Viecelli; Emma O'Lone; Jenny Shen; Michelle A Josephson; Yeoungjee Cho; David W Johnson; Bénédicte Sautenet; Marcello Tonelli; Jonathan C Craig Journal: Kidney Int Date: 2018-10-22 Impact factor: 10.612
Authors: Allison Tong; Sally Crowe; John S Gill; Tess Harris; Brenda R Hemmelgarn; Braden Manns; Roberto Pecoits-Filho; Peter Tugwell; Wim van Biesen; Angela Yee Moon Wang; David C Wheeler; Wolfgang C Winkelmayer; Talia Gutman; Angela Ju; Emma O'Lone; Benedicte Sautenet; Andrea Viecelli; Jonathan C Craig Journal: BMJ Open Date: 2018-04-20 Impact factor: 2.692
Authors: Murilo Guedes; Camila R Guetter; Lucas H O Erbano; Andre G Palone; Jarcy Zee; Bruce M Robinson; Ronald Pisoni; Thyago Proença de Moraes; Roberto Pecoits-Filho; Cristina P Baena Journal: BMC Nephrol Date: 2020-07-08 Impact factor: 2.388