Ik Dong Yoo1, Sang Mi Lee2, Jeong Won Lee3, Moo-Jun Baek4, Tae Sung Ahn4. 1. Department of Nuclear Medicine, Soonchunhyang University Cheonan Hospital, 6-31 Soonchunhyang-gil, Dongnam-gu, Cheonan, Chungcheongnam-do, 31151, Republic of Korea. 2. Department of Nuclear Medicine, Soonchunhyang University Cheonan Hospital, 6-31 Soonchunhyang-gil, Dongnam-gu, Cheonan, Chungcheongnam-do, 31151, Republic of Korea. gareen@naver.com. 3. Department of Nuclear Medicine, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, 22711, Republic of Korea. 4. Department of Surgery, Soonchunhyang University Cheonan Hospital, Cheonan, 31151, Republic of Korea.
Abstract
PURPOSE: To determine the relationship between metabolic activity of adipose tissue on FDG PET/CT and prognosis in colorectal cancer. METHODS: A total of 176 colorectal cancer patients with curative surgical resection were retrospectively enrolled. Volume and metabolic activity of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) on FDG PET/CT images were measured. The maximum standardized uptake value (SUV) of primary tumor (SUVtumor) was also obtained. Univariate analysis with log-rank test and multivariate Cox regression analyses were used to evaluate prognostic values of volume and metabolic activity of SAT and VAT as well as SUVtumor and clinicopathologic factors. RESULTS: Of 176 patients, 26 experienced recurrence during follow-up. SUVtumor showed significant correlation with serum C-reactive protein level (r = 0.242, p = 0.001), SUV of VAT (r = 0.167, p = 0.026), and size of primary tumor (r = 0.341, p < 0.001). In univariate analysis with log-rank test, SUV of VAT (p = 0.009) and SAT (p = 0.006), volume of VAT (p = 0.015), N stage (p < 0.001), M stage (p < 0.001), tumor involvement of resection margin (p = 0.001), and lymphatic invasion (p = 0.024) were significantly associated with recurrence-free survival (RFS). However, SUVtumor showed no significant association with RFS. In multivariate Cox regression analysis, SUV of VAT (p = 0.016), presence of lymph node metastasis (p < 0.001), and tumor involvement of resection margin (p = 0.011) were independent prognostic factors for RFS. CONCLUSIONS: The SUV of VAT in patients with colorectal cancer is significantly associated with FDG uptake of primary tumor. It is an independent predictor for RFS.
PURPOSE: To determine the relationship between metabolic activity of adipose tissue on FDG PET/CT and prognosis in colorectal cancer. METHODS: A total of 176 colorectal cancerpatients with curative surgical resection were retrospectively enrolled. Volume and metabolic activity of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) on FDG PET/CT images were measured. The maximum standardized uptake value (SUV) of primary tumor (SUVtumor) was also obtained. Univariate analysis with log-rank test and multivariate Cox regression analyses were used to evaluate prognostic values of volume and metabolic activity of SAT and VAT as well as SUVtumor and clinicopathologic factors. RESULTS: Of 176 patients, 26 experienced recurrence during follow-up. SUVtumor showed significant correlation with serum C-reactive protein level (r = 0.242, p = 0.001), SUV of VAT (r = 0.167, p = 0.026), and size of primary tumor (r = 0.341, p < 0.001). In univariate analysis with log-rank test, SUV of VAT (p = 0.009) and SAT (p = 0.006), volume of VAT (p = 0.015), N stage (p < 0.001), M stage (p < 0.001), tumor involvement of resection margin (p = 0.001), and lymphatic invasion (p = 0.024) were significantly associated with recurrence-free survival (RFS). However, SUVtumor showed no significant association with RFS. In multivariate Cox regression analysis, SUV of VAT (p = 0.016), presence of lymph node metastasis (p < 0.001), and tumor involvement of resection margin (p = 0.011) were independent prognostic factors for RFS. CONCLUSIONS: The SUV of VAT in patients with colorectal cancer is significantly associated with FDG uptake of primary tumor. It is an independent predictor for RFS.
Authors: Jeong Won Lee; Sung Yong Kim; Hyun Ju Lee; Sun Wook Han; Jong Eun Lee; Sang Mi Lee Journal: Cancers (Basel) Date: 2019-08-08 Impact factor: 6.639
Authors: Jeong Won Lee; Myoung Won Son; Il Kwon Chung; Young Sin Cho; Moon-Soo Lee; Sang Mi Lee Journal: Gastric Cancer Date: 2019-09-04 Impact factor: 7.370