Yukihiko Kawasaki1, Ryo Maeda2, Syuto Kanno2, Yuichi Suzuki2, Shinichiro Ohara2, Kazuhide Suyama2, Mitsuaki Hosoya2. 1. Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima, Fukushima, 960-1295, Japan. kyuki@fmu.ac.jp. 2. Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikariga-oka, Fukushima, Fukushima, 960-1295, Japan.
Abstract
BACKGROUND: To clarify the long-term efficacy of multiple-drugs combination therapy (PWDM) and tonsillectomy pulse therapy (TPT) for pediatric IgA nephropathy (IgAN), we retrospectively evaluated the clinical and laboratory findings as well as the prognosis for IgAN patients treated with each treatment at long-term follow-up. METHODS: We collected data on 61 children who had been diagnosed with severe IgAN. The children were retrospectively divided into two groups. Group 1 consisted of 44 severe IgAN children treated with PWDM, and Group 2 consisted of 17 severe IgAN children treated with TPT. The clinical features, pathological findings, and prognosis were analyzed for both groups. RESULTS: The mean urinary protein excretion, serum creatinine, IgA levels, MESTCG scores, and percentage of glomeruli showing crescents in both groups at the second renal biopsy were lower than those at the first renal biopsy. At the time of the second biopsy, the IgA level in Group 2 was lower than that in Group 1; however, there were no significant differences in the mean urinary protein excretion, frequency of hematuria, serum albumin, creatinine, or e-GFR between the two groups. At the most recent follow-up, there were no significant differences in prognosis between the groups. CONCLUSIONS: Our study suggested that PWDM and TPT are effective in ameliorating urinary abnormalities and improving the long-term outcome of pediatric IgAN.
BACKGROUND: To clarify the long-term efficacy of multiple-drugs combination therapy (PWDM) and tonsillectomy pulse therapy (TPT) for pediatric IgA nephropathy (IgAN), we retrospectively evaluated the clinical and laboratory findings as well as the prognosis for IgANpatients treated with each treatment at long-term follow-up. METHODS: We collected data on 61 children who had been diagnosed with severe IgAN. The children were retrospectively divided into two groups. Group 1 consisted of 44 severe IgANchildren treated with PWDM, and Group 2 consisted of 17 severe IgANchildren treated with TPT. The clinical features, pathological findings, and prognosis were analyzed for both groups. RESULTS: The mean urinary protein excretion, serum creatinine, IgA levels, MESTCG scores, and percentage of glomeruli showing crescents in both groups at the second renal biopsy were lower than those at the first renal biopsy. At the time of the second biopsy, the IgA level in Group 2 was lower than that in Group 1; however, there were no significant differences in the mean urinary protein excretion, frequency of hematuria, serum albumin, creatinine, or e-GFR between the two groups. At the most recent follow-up, there were no significant differences in prognosis between the groups. CONCLUSIONS: Our study suggested that PWDM and TPT are effective in ameliorating urinary abnormalities and improving the long-term outcome of pediatric IgAN.
Entities:
Keywords:
IgA nephropathy; Long-term follow-up; Outcome; Pediatrics; Tonsillectomy plus methylprednisolone pulse therapy
Authors: Mark Haas; Jacobien C Verhave; Zhi-Hong Liu; Charles E Alpers; Jonathan Barratt; Jan U Becker; Daniel Cattran; H Terence Cook; Rosanna Coppo; John Feehally; Antonello Pani; Agnieszka Perkowska-Ptasinska; Ian S D Roberts; Maria Fernanda Soares; Hernan Trimarchi; Suxia Wang; Yukio Yuzawa; Hong Zhang; Stéphan Troyanov; Ritsuko Katafuchi Journal: J Am Soc Nephrol Date: 2016-09-09 Impact factor: 10.121
Authors: John Feehally; Rosanna Coppo; Stéphan Troyanov; Shubha S Bellur; Daniel Cattran; Terence Cook; Ian S D Roberts; Jacobien C Verhave; Roberta Camilla; Luca Vergano; Jesus Egido; Andrzej Wiecek; Henryk Karkoszka; Vladimir Tesar; Dita Maixnerova; Mai Ots-Rosenberg; Marco Quaglia; Cristiana Rollino; Riccardo Magistroni; Stefano Cusinato; Raffaella Cravero; Licia Peruzzi; Sigrid Lundberg; Loreto Gesualdo; Giovanni Cancarini; Sandro Feriozzi; Franco Ferrario Journal: Nephron Date: 2015-11-20 Impact factor: 2.847