Literature DB >> 29197851

Deadly combination: Clostridium septicum and colorectal malignancy.

Carolyn Cullinane1, Helen Earley1, Shona Tormey2.   

Abstract

Gas gangrene is a life-threatening, necrotising soft tissue infection. Colorectal malignancy-associated Clostridiumsepticum is a rare cause of gas gangrene. This case outlines an initial presentation of colonic malignancy as gas gangrene from C.septicum infection.A 69-year-old man presented with abdominal pain, vomiting and constipation. Abdominal X-ray revealed dilated small bowel loops. Lactate was elevated. A diagnosis of small bowel obstruction was made. Subsequent CT revealed caecal thickening and subcutaneous emphysema overlying the left flank. Clinically, he became haemodynamically unstable. Examination revealed crepitus overlying the left flank in keeping with gas gangrene. The patient required immediate surgical debridement. Tissue specimens cultured C.septicum Following a complicated postoperative period, he was transferred to the plastic surgery team for further tissue debridement and reconstruction. A colonoscopy was later performed which was suspicious for malignancy. Colorectal multidisciplinary team discussion is awaited. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Entities:  

Keywords:  colon cancer; general surgery; infections; plastic and reconstructive surgery

Mesh:

Year:  2017        PMID: 29197851      PMCID: PMC5720338          DOI: 10.1136/bcr-2017-222759

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  10 in total

1.  Clostridium septicum infections and malignancy.

Authors:  R J Alpern; V R Dowell
Journal:  JAMA       Date:  1969-07-21       Impact factor: 56.272

2.  The role of clostridial toxins in the pathogenesis of gas gangrene.

Authors:  Dennis L Stevens; Amy E Bryant
Journal:  Clin Infect Dis       Date:  2002-09-01       Impact factor: 9.079

3.  Purification and characterization of the lethal toxin (alpha-toxin) of Clostridium septicum.

Authors:  J Ballard; A Bryant; D Stevens; R K Tweten
Journal:  Infect Immun       Date:  1992-03       Impact factor: 3.441

4.  Spontaneous, nontraumatic gangrene due to Clostridium septicum.

Authors:  D L Stevens; D M Musher; D A Watson; H Eddy; R J Hamill; F Gyorkey; H Rosen; J Mader
Journal:  Rev Infect Dis       Date:  1990 Mar-Apr

Review 5.  Malignancy, mortality, and medicosurgical management of Clostridium septicum infection.

Authors:  C M Larson; M P Bubrick; D M Jacobs; M A West
Journal:  Surgery       Date:  1995-10       Impact factor: 3.982

6.  Gas gangrene and necrotizing fasciitis in the upper extremity.

Authors:  Betsy N Perry; Waldo E Floyd
Journal:  J Surg Orthop Adv       Date:  2004

7.  Clostridium septicum Sepsis and Colon Carcinoma: Report of 4 Cases.

Authors:  Eric Mao; Aine Clements; Edward Feller
Journal:  Case Rep Med       Date:  2011-06-26

8.  Foudroyant Course of an Extensive Clostridium septicum Gas Gangrene in a Diabetic Patient with Occult Carcinoma of the Colon.

Authors:  Maximilian Hartel; Asad Kutup; Axel Gehl; Jozef Zustin; Lars G Grossterlinden; Johannes M Rueger; Wolfgang Lehmann
Journal:  Case Rep Orthop       Date:  2013-06-20

9.  Massive gas gangrene secondary to occult colon carcinoma.

Authors:  Andrew S Griffin; Matthew D Crawford; Rajan T Gupta
Journal:  Radiol Case Rep       Date:  2016-03-05

10.  Clostridium septicum Gas Gangrene in Colon Cancer: Importance of Early Diagnosis.

Authors:  Sowmya Nanjappa; Sweta Shah; Smitha Pabbathi
Journal:  Case Rep Infect Dis       Date:  2015-12-17
  10 in total
  3 in total

Review 1.  Vaccine Production to Protect Animals Against Pathogenic Clostridia.

Authors:  Nicolas E Zaragoza; Camila A Orellana; Glenn A Moonen; George Moutafis; Esteban Marcellin
Journal:  Toxins (Basel)       Date:  2019-09-11       Impact factor: 4.546

Review 2.  Bacterial Involvement in Progression and Metastasis of Colorectal Neoplasia.

Authors:  Kevin D Seely; Amanda D Morgan; Lauren D Hagenstein; Garrett M Florey; James M Small
Journal:  Cancers (Basel)       Date:  2022-02-17       Impact factor: 6.639

3.  Clostridium myonecrosis - a rare and underdiagnosed condition in the elderly: a case with severe skipping lesions and an overview of treatment guidelines.

Authors:  Ellen Van Asbroeck; Ourania Vasileiadou; Sylvie De Laere; Eddy Van Hedent; Katleen Devue
Journal:  Int J Emerg Med       Date:  2022-10-05
  3 in total

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