| Literature DB >> 29197661 |
Nikolaj Ørntoft1, Kim Frisch2, Peter Ott1, Susanne Keiding3, Michael Sørensen4.
Abstract
Positron emission tomography (PET) with 11C-cholylsarcosine (11C-CSar), a radiolabelled synthetic N-methylglycine (sarcosine) conjugate of cholic acid, is a novel molecular imaging technique that enables quantitative assessment of the individual transport steps involved in hepatic secretion of conjugated bile acids. Here, we present the method and discuss its potential clinical and scientific applications based on findings in the first human study of healthy subjects and patients with cholestasis. We also present a clinical example of a patient studied during and six months after an episode of drug-induced cholestatic liver injury.Entities:
Keywords: Bile acid transport; Cholestasis; Drug-induced liver injury; Functional molecular imaging of the liver; Hepatic transport kinetics
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Year: 2017 PMID： 29197661 DOI： 10.1016/j.bbadis.2017.11.016
Source DB: PubMed Journal: Biochim Biophys Acta Mol Basis Dis ISSN： 0925-4439 Impact factor: 5.187