Raj Sengupta1,2, Helena Marzo-Ortega1,2, Dennis McGonagle1,2, Alison Wadeley1,2, Alexander N Bennett3,4. 1. From the Royal National Hospital for Rheumatic Diseases, Bath; UK National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds; Culture and Environment College of Liberal Arts, Bath Spa University, Bath; Academic Department of Military Rehabilitation, Defence Medical Rehabilitation Centre, Headley Court, Epsom; University of Bath, Bath, UK. 2. R. Sengupta, MBBS, PGCME, FRCP, Royal National Hospital for Rheumatic Diseases, and University of Bath; H. Marzo-Ortega, LMS, MRCP, PhD, NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; D. McGonagle, FRCPI, PhD, NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; A. Wadeley, PhD, Culture and Environment College of Liberal Arts, Bath Spa University; A.N. Bennett, FRCP, PhD, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and Academic Department of Military Rehabilitation, Defence Medical Rehabilitation Centre. 3. From the Royal National Hospital for Rheumatic Diseases, Bath; UK National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds; Culture and Environment College of Liberal Arts, Bath Spa University, Bath; Academic Department of Military Rehabilitation, Defence Medical Rehabilitation Centre, Headley Court, Epsom; University of Bath, Bath, UK. alexander.n.bennett@btinternet.com. 4. R. Sengupta, MBBS, PGCME, FRCP, Royal National Hospital for Rheumatic Diseases, and University of Bath; H. Marzo-Ortega, LMS, MRCP, PhD, NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; D. McGonagle, FRCPI, PhD, NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals Trust, and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; A. Wadeley, PhD, Culture and Environment College of Liberal Arts, Bath Spa University; A.N. Bennett, FRCP, PhD, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and Academic Department of Military Rehabilitation, Defence Medical Rehabilitation Centre. alexander.n.bennett@btinternet.com.
Abstract
OBJECTIVE: Our study investigated the natural history of magnetic resonance imaging (MRI)-determined bone marrow edema over a 12-week period in individuals with suspected axial spondyloarthritis. METHODS: There were 109 MRI scans performed on 30 patients who fulfilled the Assessment of Spondyloarthritis international Society inflammatory back pain criteria at baseline and at 4, 8, and 12 weeks. RESULTS: There were 29 patients who completed the study. Only 4 (14%) patients changed from MRI-negative to MRI-positive (all HLA-B27-positive, OR 2.74). Three of 7 (43%) male HLA-B27-positive patients, 1 of 8 (12.5%) HLA-B27-positive female patients, and no HLA-B27-negative patients changed from MRI- negative to -positive. CONCLUSION: Repeat MRI scans within a 12-week period should be considered in HLA-B27-positive males.
OBJECTIVE: Our study investigated the natural history of magnetic resonance imaging (MRI)-determined bone marrow edema over a 12-week period in individuals with suspected axial spondyloarthritis. METHODS: There were 109 MRI scans performed on 30 patients who fulfilled the Assessment of Spondyloarthritis international Society inflammatory back pain criteria at baseline and at 4, 8, and 12 weeks. RESULTS: There were 29 patients who completed the study. Only 4 (14%) patients changed from MRI-negative to MRI-positive (all HLA-B27-positive, OR 2.74). Three of 7 (43%) male HLA-B27-positive patients, 1 of 8 (12.5%) HLA-B27-positive female patients, and no HLA-B27-negative patients changed from MRI- negative to -positive. CONCLUSION: Repeat MRI scans within a 12-week period should be considered in HLA-B27-positive males.
Entities:
Keywords:
AXIAL SPONDYLOARTHRITIS; DIAGNOSIS; MAGNETIC RESONANCE IMAGING
Authors: P A C Bakker; S Ramiro; Z Ez-Zaitouni; M van Lunteren; I J Berg; R Landewé; R Ramonda; M van Oosterhout; M Reijnierse; F A van Gaalen; D van der Heijde Journal: Arthritis Rheumatol Date: 2019-02-06 Impact factor: 10.995