Literature DB >> 29196314

Simultaneous impairment of neuronal and metabolic function of mutated gephyrin in a patient with epileptic encephalopathy.

Borislav Dejanovic, Tania Djémié, Nora Grünewald, Arvid Suls, Vanessa Kress, Florian Hetsch, Dana Craiu, Matthew Zemel, Padhraig Gormley, Dennis Lal, Candace T Myers, Heather C Mefford, Aarno Palotie, Ingo Helbig, Jochen C Meier, Peter De Jonghe, Sarah Weckhuysen, Guenter Schwarz.   

Abstract

Entities:  

Year:  2017        PMID: 29196314      PMCID: PMC5709744          DOI: 10.15252/emmm.201708525

Source DB:  PubMed          Journal:  EMBO Mol Med        ISSN: 1757-4676            Impact factor:   12.137


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During the process of preparing and submitting a new manuscript, which reports on novel findings regarding the mode of interaction between gephyrin and the glycine receptor, we became aware of a formal mistake. In our publication Dejanovic et al (2015) EMBO Mol Med, we compared in Fig 6E glycine receptor loop binding between wild‐type and G375D gephyrin. Unfortunately, while preparing the figure, we accidentally pulled the incorrect wild‐type raw data set for the binding curve and the derived binding parameters of the wild‐type gephyrin protein. The data in this figure were used before in our previous publication Specht et al (2011) EMBO J (https://doi.org/10.1038/emboj.2011.276). Despite this, the result and differences in binding affinities between mutant G375D and wild‐type gephyrin still hold fully true. We have provided a revised Fig 6E showing a new set of wild‐type gephyrin binding data. The authors apologise for this oversight and any inconvenience it has caused.
  2 in total

Review 1.  GABAA receptors: structure, function, pharmacology, and related disorders.

Authors:  Amr Ghit; Dina Assal; Ahmed S Al-Shami; Diaa Eldin E Hussein
Journal:  J Genet Eng Biotechnol       Date:  2021-08-21

2.  Profiling Analysis of Circular RNA and mRNA in Human Temporal Lobe Epilepsy with Hippocampal Sclerosis ILAE Type 1.

Authors:  Yifei Gu; Hongmei Wu; Tianyu Wang; Shengkun Yu; Zhibin Han; Wang Zhang; Long Mu; Hongda Wang; Meng Na; Haiyang Wang; Zhiguo Lin
Journal:  Cell Mol Neurobiol       Date:  2021-08-02       Impact factor: 4.231

  2 in total

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