Matthew Washam1, Jon Woltmann2, Beth Haberman2, David Haslam2, Mary Allen Staat2. 1. Department of Pediatrics, Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. Electronic address: Matthew.Washam@cchmc.org. 2. Department of Pediatrics, Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Abstract
CONTEXT: Methicillin-resistant Staphylococcus aureus (MRSA) causes a significant burden of illness in neonatal intensive care units (NICUs) worldwide. Identifying infants colonized with MRSA has become an important infection control strategy to interrupt nosocomial transmission. OBJECTIVE: Assess risk factors for MRSA colonization in NICUs via a systematic review and meta-analysis. DATA SOURCES: MEDLINE, Embase, Web of Science, and The Cochrane Library databases were searched from inception through September 2015. STUDY SELECTION: Studies reporting risk factors for MRSA colonization using noncolonized controls in subspecialty level III or IV NICUs were included. DATA EXTRACTION: Two authors independently extracted data on MRSA colonization risk factors, study design, and MRSA screening methodology. RESULTS: Eleven articles were included in the systematic review, with 10 articles analyzed via meta-analysis. MRSA colonization was associated with gestational age <32 weeks (odds ratio [OR], 2.67; 95% confidence interval [CI], 1.35-5.27; P = .01) and birth weight <1,500 g (OR, 2.63; 95% CI, 1.25-5.55; P = .01). Infant sex (P = .21), race (P = .06), inborn status (P = .09), and delivery type (P = .24) were not significantly associated with colonization. CONCLUSIONS: Very preterm and very-low birth weight infants were identified as having an increased risk for MRSA colonization on meta-analysis. Multifaceted infection prevention strategies should target these high-risk infants to reduce MRSA colonization rates in NICUs.
CONTEXT: Methicillin-resistant Staphylococcus aureus (MRSA) causes a significant burden of illness in neonatal intensive care units (NICUs) worldwide. Identifying infants colonized with MRSA has become an important infection control strategy to interrupt nosocomial transmission. OBJECTIVE: Assess risk factors for MRSA colonization in NICUs via a systematic review and meta-analysis. DATA SOURCES: MEDLINE, Embase, Web of Science, and The Cochrane Library databases were searched from inception through September 2015. STUDY SELECTION: Studies reporting risk factors for MRSA colonization using noncolonized controls in subspecialty level III or IV NICUs were included. DATA EXTRACTION: Two authors independently extracted data on MRSA colonization risk factors, study design, and MRSA screening methodology. RESULTS: Eleven articles were included in the systematic review, with 10 articles analyzed via meta-analysis. MRSA colonization was associated with gestational age <32 weeks (odds ratio [OR], 2.67; 95% confidence interval [CI], 1.35-5.27; P = .01) and birth weight <1,500 g (OR, 2.63; 95% CI, 1.25-5.55; P = .01). Infant sex (P = .21), race (P = .06), inborn status (P = .09), and delivery type (P = .24) were not significantly associated with colonization. CONCLUSIONS: Very preterm and very-low birth weight infants were identified as having an increased risk for MRSA colonization on meta-analysis. Multifaceted infection prevention strategies should target these high-risk infants to reduce MRSA colonization rates in NICUs.
Authors: Ibukunoluwa C Akinboyo; Annie Voskertchian; Gezahegn Gorfu; Joshua F Betz; Tracy L Ross; Karen C Carroll; Aaron M Milstone Journal: Infect Control Hosp Epidemiol Date: 2018-09-18 Impact factor: 3.254
Authors: Wenjing Geng; Yujie Qi; Wenting Li; Thomas H McConville; Alexandra Hill-Ricciuti; Emily C Grohs; Lisa Saiman; Anne-Catrin Uhlemann Journal: PLoS One Date: 2020-02-13 Impact factor: 3.240