Huajie Han1, Renfang Hu2, Faiz Wali2, Zhao Wu2, Kun Gao2, Shenghao Wang3, Yonggang Gu4, Yi Jin4, Chao Zhai5. 1. Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei 230027, China; National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230027, China. 2. National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230027, China. 3. Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Science, Shanghai 201800, China. 4. Experimental Center of Engineering and Material Science, University of Science and Technology of China, Hefei 230027, China. 5. Experimental Center of Engineering and Material Science, University of Science and Technology of China, Hefei 230027, China. Electronic address: zhaichao@ustc.edu.cn.
Abstract
PURPOSE: In this paper, we propose a novel method for human body composition measurement, especially for the bone mineral density (BMD) measurement. The proposed method, using the absorption and differential phase information retrieved from X-ray grating-based interferometer (XGBI) to measure the BMD, has potential to replace dual-energy X-ray absorptiometry (DEXA), which is currently widely used for body composition measurement. METHODS: The DEXA method employs two absorption images acquired at two different X-ray spectra (high energy and low energy) to calculate the human body composition. In this paper, a new method to calculate BMD using a single X-ray measurement is proposed. XGBI is a relatively new X-ray technique that provides absorption, phase and scattering information simultaneously using a single X-ray spectrum. With the absorption and differential phase information retrieved from XGBI, BMD can be measured using only one single X-ray spectrum. Numerical simulations are performed with a body phantom of bone (Cortical, ICRU-44) surrounded by soft tissue (Soft, ICRU-44). BMD is calculated with both the DEXA method and the proposed method. RESULTS: Results show that BMD can be measured accurately with the proposed method; moreover, better signal-to-noise ratio (SNR) is obtained compared to DEXA. CONCLUSION: With the proposed method, BMD can be measured with XGBI setup. Further, the proposed method can be realized using current X-ray phase-contrast imaging (XPCI) apparatus without any hardware modification, suggesting that this technique can be a promising supplementary function to current XPCI equipment.
PURPOSE: In this paper, we propose a novel method for human body composition measurement, especially for the bone mineral density (BMD) measurement. The proposed method, using the absorption and differential phase information retrieved from X-ray grating-based interferometer (XGBI) to measure the BMD, has potential to replace dual-energy X-ray absorptiometry (DEXA), which is currently widely used for body composition measurement. METHODS: The DEXA method employs two absorption images acquired at two different X-ray spectra (high energy and low energy) to calculate the human body composition. In this paper, a new method to calculate BMD using a single X-ray measurement is proposed. XGBI is a relatively new X-ray technique that provides absorption, phase and scattering information simultaneously using a single X-ray spectrum. With the absorption and differential phase information retrieved from XGBI, BMD can be measured using only one single X-ray spectrum. Numerical simulations are performed with a body phantom of bone (Cortical, ICRU-44) surrounded by soft tissue (Soft, ICRU-44). BMD is calculated with both the DEXA method and the proposed method. RESULTS: Results show that BMD can be measured accurately with the proposed method; moreover, better signal-to-noise ratio (SNR) is obtained compared to DEXA. CONCLUSION: With the proposed method, BMD can be measured with XGBI setup. Further, the proposed method can be realized using current X-ray phase-contrast imaging (XPCI) apparatus without any hardware modification, suggesting that this technique can be a promising supplementary function to current XPCI equipment.