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Literature DB >> 291944

Successful treatment of autoimmune disease in (NZB/NZW)F1 female mice by using fractionated total lymphoid irradiation.

Abstract

Adult female (NZB/NZW)F1 hybrid mice with documented autoimmune glomerulonephritis resembling systemic lupus erythematosus were treated with fractionated total lymphoid irradiation (TLI), a modification of the radiotherapeutic regimen currently used for the treatment of Hodgkin disease. After TLI, proteinuria subsided in all mice that had undergone radiotherapy, and the mean survival increased from 359 days in untreated controls to 545 days. It is suggested that TLI should be further investigated as a new approach for immunoregulation of autoimmune disorders.

Entities: Disease Species

Mesh：

Year: 1979 PMID： 291944 PMCID： PMC413123 DOI： 10.1073/pnas.76.10.5274

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

20 in total

1. Generation of protein-specific and alloantigen-specific suppressor cells following total lymphoid irradiation in mice.

Authors: S Slavin; I Zan-Bar; S Strober
Journal: Transplant Proc Date: 1979-03 Impact factor: 1.066

2. Long term effects of radiation of T and B lymphocytes in peripheral blood of patients with Hodgkin's disease.

Authors: Z Fuks; S Strober; A M Bobrove; T Sasazuki; A McMichael; H S Kaplan
Journal: J Clin Invest Date: 1976-10 Impact factor: 14.808

3. Transplantation of bone marrow in outbred dogs without graft-versus-host disease using total lymphoid irradiation.

Authors: S Slavin; M Gottlieb; S Strober; C Bieber; R Hoppe; H S Kaplan; F C Grumet
Journal: Transplantation Date: 1979-02 Impact factor: 4.939

4. Transplantation tolerance after total lymphoid irradiation.

Authors: S Strober; S Slavin; Z Fuks; H S Kaplan; M Gottlieb; C Bieber; R T Hoppe; F C Grumet
Journal: Transplant Proc Date: 1979-03 Impact factor: 1.066

5. Comparison of therapeutic and immunosuppressive effects of azathioprine, prednisolone and combined therapy in NZP-NZW mice.

Authors: B H Hahn; M K Bagby; T R Hamilton; C K Osterland
Journal: Arthritis Rheum Date: 1973 Mar-Apr

6. Induction and mechanism of tolerance to bovine serum albumin in mice given total lymphoid irradiation (TLI).

Authors: I Zan-Bar; S Slavin; S Strober
Journal: J Immunol Date: 1978-10 Impact factor: 5.422

7. Thoracic duct drainage in SLE with cutaneous vasculitis. A case report.

Authors: K E Nyman; R Bangert; H Machleder; H E Paulus
Journal: Arthritis Rheum Date: 1977-06

8. Induction of specific tissue transplantation tolerance using fractionated total lymphoid irradiation in adult mice: long-term survival of allogeneic bone marrow and skin grafts.

Authors: S Slavin; S Strober; Z Fuks; H S Kaplan
Journal: J Exp Med Date: 1977-07-01 Impact factor: 14.307

9. Transplantation tolerance in adult rats using total lymphoid irradiation: permanent survival of skin, heart, and marrow allografts.

Authors: S Slavin; B Reitz; C P Bieber; H S Kaplan; S Strober
Journal: J Exp Med Date: 1978-03-01 Impact factor: 14.307

Successful treatment of autoimmune disease in (NZB/NZW)F1 female mice by using fractionated total lymphoid irradiation.

1. Generation of protein-specific and alloantigen-specific suppressor cells following total lymphoid irradiation in mice.

2. Long term effects of radiation of T and B lymphocytes in peripheral blood of patients with Hodgkin's disease.

3. Transplantation of bone marrow in outbred dogs without graft-versus-host disease using total lymphoid irradiation.

4. Transplantation tolerance after total lymphoid irradiation.

5. Comparison of therapeutic and immunosuppressive effects of azathioprine, prednisolone and combined therapy in NZP-NZW mice.

6. Induction and mechanism of tolerance to bovine serum albumin in mice given total lymphoid irradiation (TLI).

7. Thoracic duct drainage in SLE with cutaneous vasculitis. A case report.

8. Induction of specific tissue transplantation tolerance using fractionated total lymphoid irradiation in adult mice: long-term survival of allogeneic bone marrow and skin grafts.

9. Transplantation tolerance in adult rats using total lymphoid irradiation: permanent survival of skin, heart, and marrow allografts.

10. Transplantation of allogeneic bone marrow without graft-versus-host disease using total lymphoid irradiation.

1. The role of suppressor T cells in the expression of autoimmune haemolytic anaemia in NZB mice.

2. Immunomodulation of autoimmunity in MRL/lpr mice with syngeneic bone marrow transplantation (SBMT).

3. Rationale for bone marrow transplantation in the treatment of autoimmune diseases.

Review 4. Non-myeloablative stem cell transplantation for autoimmune diseases.